Why Does Testosterone Decrease | The Truth About How to Boost Testosterone- Thomas DeLauer
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the simple science of testosterone beyond just building muscle beyond all the things we hear about and a little bit more and how it works more so with your brain than just other parts of your body I want to explain in this video what really happens when you have that natural decline in testosterone and say after age 30 or so I want to explain and really have you understand what’s happening hormonal II and why things shut down because I think once there’s an understanding there a lot of things just start to make more sense now I want to start out by talking about something called the HP ta the hypothalamic pituitary gonadal axis it’s a mouthful so we’re just going to refer to it as the HPA axis basically it’s super complex but I’m going to make it simple it comes down to three parts of your body your hypothalamus your pituitary which are both in your brain and of course your testes now the production of testosterone starts with the hypothalamus you see the hypothalamus creates something that’s called GnRH it’s a hormone in that hormone triggers the pituitary another portion of your brain to create two hormones that are called luteinizing hormone LH and follicle stimulating hormone FSH those two hormones LH and FSH are absolutely imperative when it comes down to creating testosterone you see because what they do is after the pituitary gland has created them is they travel way on down from the brain down into your loins and into the testes where they actually are combined with cholesterol to ultimately produce testosterone and other sex hormones they combine with those cholesterol and these things called Leydig cells and from there you are creating testosterone you’re also creating some other hormones you’re even creating progesterone you’re even creating some of these other things that affect your energy levels but for now we’re going to focus mainly just on testosterone now once that LH and FSH are down in the testes getting converted into the proper hormones it’s important to know what happens you see the LH combines with cholesterol so that we consume and cholesterol that are created to create that testosterone while the FSH combines with cholesterol and foods that we eat to ultimately create the sperm count you see they work hand in hand obviously we need to start your own we need a libido but we also need the sperm count for simple procreation reasons it’s the purpose of testosterone in the first place so that’s how that really works down there without those Leydig cells that allow that conversion to happen you just have LH and FSH floating around through the body with nothing ever happening now another thing that’s important to know is that your brain isn’t always producing that GnRH you see we have to take special care of our brain it’s way more important than we think that hypothalamus that is producing that GnRH is only producing it in pulses you see a lot of times we hear that testosterone levels are higher in the morning well it’s mainly because our brain is producing a pulse of GnRH usually first thing in the morning but what’s interesting enough is that it doesn’t just go with time of day it also goes with circadian rhythm when you sleep but also can go with time of year interestingly enough GnRH and testosterone levels are usually higher in the springtime and it makes sense when we think about it from an evolution standpoint why would we want to be procreating in the wintertime when in some regions it’s absolutely sub-zero and barely survivable so as it starts to get warmer of course then our brain not our testes but our brain senses that it’s time for more testosterone you see I think the fixation has to come off of testosterone in general and think more about brain health because our brain needs to realize that it’s time to produce testosterone so as long as we protect that with a golden sword and really think about it then we can be well on our ways to having better testosterone levels ok so it’s all fine and dandy now right except we got to take it one step further because you know me I’m always throwing a wrench in things and throwing more science and making it super complicated because that’s just the way I roll but anyway it goes down to one more thing you see then we go into what is called DHT DHT is dehydrate estas room dihydrotestosterone is the actual usable form of free testosterone when it comes down to building muscle when it comes down to growing a beard when it comes down to having a sex drive when it comes down to getting that six-pack it comes down to that DHT well news flash for you DHT or that free form of testosterone only makes up about 2% of the overall testosterone that you’ve gone through this entire process to create only 2% if you’re lucky the other 98% bound to something called the sex hormone-binding globulin another topic for another day but basically what that SHBG does is it locks that testosterone within the sex hormone world creating testosterone for later creating cortisol creating different progesterone creating pregnenolone other hormones that create other hormones so basically we’re left with a small 2% well as our levels of testosterone decline you can imagine how that 2% gets even smaller and smaller and smaller so that precious 2% that we’ve got the build muscle or to have a sex drive or to have energy or to have strong bones declines and declines with age and it becomes more precious now another thing to note that’s pretty interesting is something called a negative feedback loop you see when you have enough testosterone produced as a safety mechanism to not produce too much your brain recognizes it you see it’s got what are called androgen receptors these androgen receptors see that you have enough testosterone floating around and it says okay brain don’t produce anymore hormones to create testosterone basically we have enough testosterone don’t create too much we don’t want to cause a problem that is called a negative feedback loop the brain is very smart you can’t outsmart your brain that’s why those that are using exhaustion as’ testosterone usually have an issue with getting their natural levels back up to par because that negative feedback loop is artificially disrupted well that can also happen with aging at a different level you see as testosterone levels decline and as gnrh declines a lot of times your body starts to create more LH and FSH in an effort to produce more testosterone well creating more LH and more FSH can trigger that negative feedback loop that ultimately shuts down to stature and production even more but I would say the most common reason that men over 30 start to have a decline in testosterone is mainly because of those Leydig cells as Ladak cells that are down in the testes that convert the LH and FSH into a usable form of testosterone by combining with cholesterol you see they shrink they die off they actually atrophy and decrease in mass which means there’s less area for them to convert that cholesterol so there’s some ways that I’m going to explain that you can combat that just simply through your nutrition comes down to timing more than anything we talked about that gnrh we talked about that LH and FSH but we also have to look at the natural pulses you see if we don’t have a hypothalamic issue or pituitary issue where we’re still at least producing the hormones that derive testosterone production then all we have to do is get ourselves some more cholesterol so we can at least increase the potential to convert more testosterone you see if you have a late Excel that say this big and it’s obviously enlarged then you’re going to have X amount of cholesterol that comes in well it’s only going to be able to utilize some of that cholesterol the rest is going to float around to other parts of the body as that cell gets smaller because of age need to make sure you’re getting the right kind of cholesterol and increasing your good healthy cholesterol so that you have a better chance of grabbing those cholesterol and converting them into testosterone now the other thing that you can really do to help your natural testosterone levels you stop focusing on just testosterone and focus on your brain so you take care of your brain with the right kind of fats you know with the right kind of omega-3s versus omega-6 heck even meditation as cheesy as it may sound you have to protect this house because that is the catalyst for everything that creates the body that you want but then last but not least you want to eat your fats predominantly in the morning get them in the morning when your brain is already stimulating that GnRH pulse as is even if it’s declined even if it’s smaller capitalize on that and try to get the most out of your testosterone levels there’s a bunch of other ways that you can do that and I’m going to ask you to watch my interview on ESPN that I did with dr. Cole specifically talking about this topic dr. Cole is the team physician for the Chicago Bulls he’s the team physician for the Chicago White Sox but basically what we are going to discuss is natural ways to increase your testosterone but also talk a little bit more about how you can take care of this HPA axis and get the most out of your life as always keep it locked in here on my videos and on my channel and if you have any ideas for videos post them in the comment section below so that I can determine which ones are gonna be the best for you as always see you in the next video
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Why Does Testosterone Decrease? How Testosterone Declines in Men (Physiologically, HPTA Axis, etc)
HPTA = Hypothalamic Pituitary Gonadal Axis
This axis produces circulating steroids important for male sexual function, fertility and development.
Prostate and penis are steroid sensitive organs impacted by the regulation of the HPTA.
This reproductive axis consists of three parts:
-Produces GnRH (gonadotropin-releasing hormone)
2. Pituitary Gland
-GnRH is sent to the pituitary gland where it stimulates the synthesis and release of gonadotropic hormones LH and FSH.
-Gonads carry LH to the testis where they stimulate testosterone production through the testicular Leydig cells
-Testosterone is produced by conversion of cholesterol
-FSH is crucial for spermatogenesis
Dihydrotestosterone (DHT) is the activated form of testosterone. 2% of testosterone is free or unbound, with the remainder being bound to SHBG (sex hormone-binding globulin), albumin- and cortisol-binding globulin. Bioavailable testosterone is the testosterone that is not bound to SHBG. Testosterone and DHT act on organs.
-Causes development of secondary sexual characteristics
-Inhibit secretion of LH and FSH by the pituitary gland, thus stops further testosterone production = negative feedback loop.
-There exist androgen receptors in the pituitary and the hypothalamic neurons that bind to testosterone and signal to stop GnRH release
Homeostasis is maintained through this loop – once testosterone stops being produced, this inhibited secretion stops and GnRH again causes LH and FSH release to produce further testosterone. As men age, they undergo hormonal level changes:
-LH and FSH increase
-Other hormones that decrease: T3, insulin, growth hormone/insulin-like growth factor 1, thyroid stimulating hormone
-Also an increase in SHBG
-Dihydrotestosterone levels are unchanged
-Estrogen levels unchanged
As men age, the decrease in testosterone paired with the increase in SHBG leads to a decline in free, or bioavailable, testosterone. These hormonal changes start in the 30s and are well established by the 50s. Levels of testosterone vary greatly between men and not all men will be classified as hypogonadal as they age.
What causes these hormone changes?
1. Testicular failure due to a decline in Leydig cell mass
2. Hypothalamic-pituitary system, or secondary hypogonadism failure
-Believed not to be due to primary hypogonadism (disease of the testes) due to small increase in LH and decrease in responsiveness of LH and FSH to GnRH
3. Change in androgen receptor site sensitivity
One can distinguish between those with pituitary disorders or hypothalamic disease by administering GnRH. Those with pituitary disorders will not respond by producing more LH and FSH whereas those with hypothalamic disorders will respond with increased LH and FSH. Numerous studies have shown a positive impact of healthy, dietary fat intake on testosterone levels in men. Cholesterol is tied to the production of sex hormones. Testosterone is created in the Leydig cells when LH triggers the cells to convert cholesterol into testosterone. Cholesterol is the precursor to pregnenolone, which is the precursor of steroid hormones. Pregnenolone is the precursor of progesterone, which is then converted into testosterone (progesterone is also converted into cortisol and aldosterone.)
Consume: fatty fish, olive oil, nuts and avocados.
1. Age-associated testosterone decline in men: clinical issues for psychiatry
2. Pathophysiology course – endocrine module – male gonadal disorders
3. Cholesterol is the precursor for all steroid hormones
4. Testosterone physiology in resistance exercise and training
5. Diet and serum sex levels in healthy men
6. An Introduction to Steroids and Negative Feedback Loops
7. Testosterone Treatment for Men – T, HCG, ARIMIDEX
8. The Interaction of Testosterone and Cortisol is Associated with Attained Status in Male Executives