Leaky Gut Fix: Glutathione and Digestion: Thomas DeLauer

Leaky Gut Fix: Glutathione and Digestion: Thomas DeLauer

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how would you like that breakfast that you just ate to slip on right through your intestinal tract and end up in your bloodstream in giant chunks rather than digested material well that may be a bit extreme but that’s basically what’s happening with a leaky gut well in this video I want to show you some science that’s actually proving that glutathione may be something that can help out with a leaky gut but let me explain a little bit more about what a leaky gut is and then explain what glutathione is and then wrap it all together with some science with a nice little bow on top so it all makes sense so a leaky gut also known as intestinal hyper permeability just like the name implies it means that things are flowing through your intestinal tract into your bloodstream that shouldn’t it’s when our gut lining is so broken down and worn down from inflammation from bad foods from stress from lack of antioxidant that food particles can slip on through into the bloodstream why is that bad well these food particles trigger the immune system to activate on high alert this can cause us to feel rundown it can totally zap our energy levels but it can also trigger some autoimmune issues because the body starts activating all kinds of antibodies and activating all kinds of immune responses this can lead to intolerances it can lead to food cravings it can lead to weight gain it can lead to autoimmune issues and it can ultimately even lead to some hormonal imbalances it’s a big problem right now and that’s probably why we’re seeing so much about it but let’s stop with the anecdotal stuff and let’s start breaking down real science and one thing that I like to talk about a lot is glutathione okay glutathione is known as the mother of all antioxidants because our body’s built-in defense mechanism it’s our body’s built-in insurance policy and detoxification agent and how does it have a correlation with a leaky gut well you see glutathione is a tripeptide it’s made up of three simple amino acids that are ultimately synthesized into this substance called glutathione well what that glutathione does is it travels around or exists in the cell with an extra electron that electron acts as sort of a lure to catch free radicals because those free radicals need an electron to pair with I know we’re getting into some crazy old school biology here but it’s actually very basic when it’s put in that analogy basically that glutathione has a hook on it that hook attaches that spare oxygen that is your free radical and neutralizes it but when we have these issues going on in the gut all the time we have tons of inflammation tons of stress it would make sense that we need additional glutathione at the source there but I want to reference some studies that break down some legitimate evidence that glutathione may be linked to a leaky gut you see when we’re under stress we have a high level of reactive oxygen species we have a high level of those free radicals and that exists predominantly in the gut and since glutathione is so present in the gut it’s spending all of its energy neutralizing extra free radicals in the gut so our gut is never getting a chance to heal so even if you don’t have a leaky gut to begin with you’re compromising your immune system you’re compromising your body’s ability to rebuild the intestinal lining that naturally gets sort of depleted now the first study that I want to reference looked at inflammatory bowel disease okay where you just have inflammation – now the bowels typically like Crohn’s disease now it’s a good indicator in a good test because we have direct implementing and a direct level of lots of free radicals right at the source there so what this study looked at was what our levels of glutathione were doing when we had irritable bowel disease but what they found is that there were elevated levels of glutathione disulfide that glutathione disulfide is the already used form of glutathione suggesting that when there was inflammation and when there was disease our bodies were depleted in active through the thigh on because that glutathione was being used to try to recover from the inflammatory bowel disease I know it’s a lot to put together but that’s how we can take science and make a direct correlation now the next study is even more interesting this one looked at celiac patients okay patients that had issues with gluten and had an intolerance to gluten manifesting in celiac disease took 39 patients and then took 19 in the control study 19 it didn’t have celiac and the and did well they found some interesting stuff with this study as well what they looked at in this study was a levels of what are called lipid peroxidation and to make it simple lipid peroxidation is when fats turn into free radicals when fats are oxidized that lipid peroxidation you’ll hear me talk about it quite frequently in some of my videos that’s all it means it means fats that are usually in the intestinal tract are turning into something bad so what they found is that lipid peroxidation increased in the presence of celiac disease directly correlating with a diminished antioxidant level and diminished levels of glutathione in the body suggesting that the antioxidant effects those with celiac disease and inflammation in the intestinal tract are directly correlated by a decrease in glutathione now again this isn’t the end-all be-all and it’s not here to totally break science and say that this is the way it’s going to be forever but the fact that we’re starting to find some correlation between these advanced studies these peer-reviewed studies glutathione our immune system and a leaky gut it’s pretty amazing so what can you do well first and foremost make sure you’re keeping on top of those free radicals whether that means being the right kind of foods whether that means supplementing with a little bit of cysteine to help that glutathione production or taking the easy way and just using some glue that’s ion exogenously in the first place to help your body out – give it a break make sure that you’re keeping an eye on the mother of all antioxidants because at the end of the day the only things that is looking out for you is you I’ll see on the next video

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Leaky Gut Fix: Glutathione and Digestion: Thomas DeLauer
How Does Glutathione Work?
Glutathione exists within cells in its reduced form (GSH), meaning it has an extra electron.
In the process of neutralizing reactive oxygen species it becomes oxidized (GSSG), but reacts with another oxidized glutathione to become glutathione disulfide. (5, 7)
What causes glutathione depletion?
– Our body makes sufficient glutathione to help keep everything running smoothly, however it becomes depleted as a result of extreme stress
– Stressors include: insulin surges from sugary, high-carb diets, immune aggravation from food intolerances, gut infections, hormonal imbalances, lack of sleep, smoking/drinking and hectic lifestyles
Glutathione and a Leaky Gut
A low level of liver glutathione is a common occurrence in leaky gut syndrome
Leaky Gut Syndrome is used to describe the condition of “Hyperpermeable Intestines”
A condition that allows all kinds of substances, such as toxins, bacteria and undigested food particles to pass through the junctions in your small intestine and enter your bloodstream
In other words, the intestinal lining has become more permeable (leaky), with more holes developing that are larger in size and the screening out process is no longer functioning properly
Glutathione May Protect Your Gut
– Research has shown that glutathione may help improve gut health by decreasing oxidative stress
Case Study #1: Looked at the impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease
– Study investigated basic amino acid plasma levels and the glutathione status in IBD with an emphasis on intestinal glutathione synthesis in Crohn’s disease
– Reduced glutathione (rGSH) and oxidised glutathione (GSSG) were determined enzymatically in peripheral blood mononuclear cells, red blood cells, muscle, and in non-inflamed and inflamed ileum mucosa.
Results
– Abnormally low cysteine and cystine levels were associated with inflammation in IBD
– Decreased rGSH levels were demonstrated in non-inflamed mucosa and inflamed mucosa in patients with IBD, while GSSG increased with inflammation compared with controls
Conclusion
– Decreased activity of key enzymes involved in glutathione synthesis accompanied by a decreased availability of cysteine for glutathione synthesis contribute to mucosal deficiency in IBD
– Glutathione deficiency might be a target for therapeutic intervention in IBD. (8)
Case Study #2: Looked at the antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease
– Activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects
Results
– Activities of analyzed enzymes varied significantly between the examined groups
– An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced
– The level of lipid hydroperoxides was significantly elevated in these groups (9)
References
1) Glutathione: New Supplement on the Block. (n.d.). Retrieved from
2) The Health Dividend of Glutathione | Natural Medicine Journal. (n.d.). Retrieved from
3) What is Glutathione? (n.d.). Retrieved from
4) Intestinal Permeability: Clinical Unwinding of Leaky Gut | San Jose Functional Medicine. (n.d.). Retrieved from
5) Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases. (n.d.). Retrieved from
6) How to Heal Leaky Gut Syndrome: 20 Tips From Gut Health Experts. (n.d.). Retrieved from
7) BodyBio Health News | Glutathione: It’s Your Gut. (n.d.). Retrieved from
8) Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. – PubMed – NCBI. (n.d.). Retrieved from
9) Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. – PubMed – NCBI. (n.d.). Retrieved from 8

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