Anxiety Relief: Reduces Stress with St. John’s Wort- Thomas DeLauer
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st. John’s wort sounds like a vacation destination down in the Bahamas or something like that or possibly even some guy named John’s Harry Borg but that’s not what we’re talking about at all we’re talking about Hypericum perforate ‘m which is a flower Lea little plant that basically is showing to help relieve depression help relieve stress and actually show some positive improvement in terms of reducing biomarkers of stress in the first place so I wanted to do this video because I think that everyone deserves an understanding of how stress really happens in the body and how that neuro criminis tree works when it comes down to depression when it comes down to stress and how st. John’s wort is showing to be a pretty effective way at at least mitigating some of the biomarkers that cause stress or are being shown from stress so let’s dive in a little bit more about what st. John’s wort is but let’s also talk about how neuro chemistry works when it comes down to that so okay what is chronic stress like we hear about it all the time we think we have it but really what is it well I’m gonna get down to the neuro chemistry of that in just a second but it’s important to note that over time if you do have a lot of chronic stress that’s just compounding and compounding and compounding it can eventually lead to symptoms of depression and the reason I say symptoms of depression is because depression is one of these ambiguous sort of diagnoses that really doesn’t have a solid answer as to what it is you know we just can say someone’s depressed but a lot of times when it comes down to is an interruption of the neurotransmitters that are critical for us feeling our best you know those are things like serotonin dopamine norepinephrine even things like acetylcholine those kind of neurotransmitters are responsible for really keeping us in check and keeping us in balance and when those are interrupted or thrown off or maybe deficient or even too much it can cause symptoms of anxiety and depression the thing is chronic stress changes some things within your body that can actually make you feel that way and start causing some issues with those neurotransmitters so we say it can lead to symptoms of depression even though it may not be an official link to depression after all but there is one promising thing and that promising thing is an herbal supplement called st. John’s wort that is showing that it has a pretty positive effect when it comes to reducing the biomarkers of stress and reducing those overall symptom of depression so let’s talk a little about how brain neurochemistry works when it comes to this you see st. John’s wort really has two components to it has one component that’s called hyper sarin in one component called hyperforin and they each do two different things that are pretty critical so let’s talk about hyper sarin what hyper sarin does is it increases the blood flow to the capillaries basically what that means is you’re increasing blood flow to really small blood vessels particularly in the brain the brain has a lot of capillaries so an increase in blood flow right then and there can increase brain activity so if you’re fatigued all the time right then and there you can be solving that issue at least somewhat but the other thing that this hyper sarin does is it inhibits enzymes that are called the mao-a enzyme and the mao-b enzyme and what these enzymes do is that they can end up interrupting those neurotransmitters that I talked about they can interrupt the path of the serotonin of that norepinephrine of that acetylcholine so when we can actually inhibit those enzymes the mao-a and the mao B’s we can slow down that process we can help our neurotransmitters out we can make it so they’re not getting as interrupted that’s just one component of what st. John’s wort can do the next component of st. John’s work is called hyperforin and before I go into what hyperforin is I have to explain the reuptake strategy or the reuptake method within the brain how that works with neurotransmitters you see when you produce neurotransmitters the brain doesn’t always utilize them immediately doesn’t always get an effect from them so a lot of times let’s just use serotonin for example your brain will produce serotonin so a neurotransmitter and that neurotransmitter will not get utilized all the way so your body will retake it and sort of recycle it which means you’re not getting the full effect of that neurotransmitter well what this hyperforin is is it is a real take inhibitor and you may have heard of different kinds of antidepressants that are SSRIs like serotonin reuptake inhibitors well that’s the whole process that works is you’re inhibiting that reuptake so basically in very simple terms what that means is that an uptake inhibitor allows that neurotransmitter to stick around longer and have a more powerful effect before it’s eventually reuptake and used again and recycle now the interesting thing is hyperforin or st. John’s wort doesn’t work in the traditional fashion that say a normal that would work it works through a whole different mechanism of action now I can go into this in another video but basically what it does is it increases sodium and calcium which basically means that the gradient between the neuron and a synaptic cleft is a little bit better in terms of being able to let that neurotransmitter survive if you will again a fancy way of saying providing the perfect environment for a neurotransmitter to stick around and have a more powerful effect on the brain serotonin can help you feel good norepinephrine can help you be motivated and energized dopamine can help you feel like you have a reward epinephrine in general can just help you feel excited and feel like everything is good in the world so when those neurotransmitters are sticking around and they’re actually able to be utilized and not just getting retaken by the brain you can see how you have a very positive effect so let’s talk about how chronic stress in st. John’s wort actually loop back together how this all comes back full circle you see when we’re stressed out for an extended period of time it starts changing somewhere a brain chemistry and it can interrupt and affect something that’s called the hypothalamus pituitary adrenal axis I know it’s a mouthful to say but it’s a fancy scientific way of saying the brain’s ability to communicate with the adrenals and when that is completely thrown off what happens is it’s been shown that our bodies produce more important called glucocorticoids steroids now glucocorticoid steroids are our steroid hormones like cortisol we all hear about cortisol that’s the link between stress and cortisol it all has to do with our brain our brain is stressed out the neuro chemistry is all out of whack so it’s ability to communicate with the adrenals is thrown off meaning our bodies are producing more of those glucocorticoid steroids like cortisol now it’s been shown in some additional studies that glucocorticoid steroids actually change the dynamic of the brain and can actually emulate symptoms of depression which means the plasticity of the brain changes our brains dynamic our brains overall biome is different so we start feeling depressed that’s why people that are under a lot of stress and show symptoms of depression an interesting study to back up the effect of st. John’s wort on chronic stress was done in 2011 where they took stressed-out rats and they gave them a supplemental dose of st. John’s wort what they found over time is that the st. John’s wort dramatically reduced their glucocortic
oid steroid levels their cortisol levels mainly due to the fact that it changed the plasticity in their brain it actually allowed them to basically modify their brain so that they were able to feel better so that neuro transmitters functioned a little bit better it actually changed what’s known as the plasticity of the brain so pretty compelling evidence when it comes down to that research study but lastly I want to talk about inflammation because I’m always talking about it you all know me as the inflammation guy I probably drive you crazy with all my stuff on Facebook and all my stuff on YouTube about inflammation is now being shown that st. John’s wort can actually inhibit the genes that cause inflammation or at least slow them down so we’re talking about the cyclooxygenase enzyme – which is a huge one that cyclooxygenase enzyme – is the enzyme that aspirin inhibits so basically you’re taking an aspirin to reduce inflammation by reducing that cyclooxygenase enzyme – that shows you how important that one is so if we can reduce that through st. John’s wort that’s pretty remarkable then we’re also talking about reducing interleukin 6 which is one of the biggest triggers for inflammation in general when interleukin 6 is released our body goes in this crazy inflammatory response interleukin 6 is triggered when we have a disease state or when we have a serious injury and lastly you can reduce something that’s known as the nitric oxide synthase enzyme now that nitric oxide synthase is more of a localized inflammation situation so if you have chronic pain in one area a lot of times it could be the result of that so st. John’s wort is showing some positive signs in the world of inflammation we could be seeing a lot more of it in the future which I personally just find extremely fascinating so I guess at the end of the day the purpose of this video was to explain that entire link between neuro chemistry between our brain between chronic stress so you really have a keen understanding of it because you know what really ends up happening is if you’re stressed out all the time then you’re screwing up your neuro chemistry I mean start screwing up your neuro chemistry then you’re actually screwing up the ability for your brain to communicate with your adrenals and when you start going down that road then you’re messing up your hormone levels and when you start messing up your hormone levels and increase in your cortisol levels well then you’re not able to absorb your nutrients as much because your body really starts thinking that it’s in that fight-or-flight mode all the time which means your metabolism slows down which means your liver starts prioritizing other things it’s this cascading effect that can make you feel horrible and I have people coming to me all the time that are just saying they feel like they’re depressed they don’t always say they’re depressed they just say they feel like they’re depressed but then when you actually start diagnosing what’s going on in terms of their life they’re stressed out they’re chronically stressed out and they’re not giving themselves a break so they’re actually starting to affect themselves metabolically speaking so even if Saint John’s wort isn’t the trick for you specifically I encourage you to start getting a grasp on your stress because it can directly have an effect with your overall body and as always post a comment down below this video and let me know what kind of videos you want to see specifically pertaining to stress I’m fascinated with stress and I’d love to do more content surrounding it to be able to help the most possible amount of people that I can and as always keep it locked in here in my videos for more ways to get educated not only on nutrition but how to live the best life possible see you soon
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St. John’s Wort is also known as hypericum perforatum. It is a flowering plant that has been used for thousands of years as a medicinal herb. Key uses are as an antidepressant and an anti-inflammatory. Widely used around the world today for mild to moderate depression. There are many studies that support the use of SJW for these purposes, however understanding exactly how it is working is still under way today. SJW has been shown to help reduce biomarkers of stress, which ties into both depression and inflammation.
Depression and Stress: Chronic stress can lead to depression symptoms, including anxiety, fatigue, sleeping trouble and loss of appetite. It is also known to lead to cognitive impairment, harming memory ability and mental functioning. There are many ways that SJW has been shown to help reduce depression. Below are just a few of the ways the SJW is able to help reduce biomarkers of stress. Depression is thought to be caused by an interruption in brain neurochemistry, particularly from a deficiency of neurotransmitters, including acetylcholine, serotonin, dopamine and norepinephrine. SJO increases the availability of serotonin, dopamine and norepinephrine in the brain. These help to improve your mood, reducing symptoms of depression. Hypericin and hyperforin are thought to be two of the most important components of SJW that reduce depression symptoms.
Hypericin stimulate capillary blood flow and inhibit the enzymes MAO-A and MAO-B. These enzymes are involved in the degradation of the neurotransmitters listed above. It also helps to regulate dopamine levels and action potentials caused by neurotransmitters. Hyperforin is a reuptake inhibitor, making it so neurotransmitters such as serotonin and dopamine are able to create a greater response. This reuptake inhibition does not work the same way that traditional antidepressants work. Rather than blocking 5-HT receptors, SJW results in increased concentrations of sodium and calcium. By making it so that the gradient between the neuron and the synaptic cleft is lesser, reuptake of monoamine neurotransmitters is decreased. It also increases the number of 5-HT receptors, showing possible long-term therapeutic benefit to supplementation. Chronic stress causes interruption of the hypothalamo-pituitary-adrenal (HPA) axis, leading to an overproduction of glucocorticosteroids.
St. John’s Wort has been shown to inhibit genes critical to chronic inflammation. These include the pro-inflammatory cyclooxygenase-2, inducible nitric oxide synthase and interleukin-6. Nitric oxide (NO) synthase is an enzyme that catalyzes the creation of nitric oxide from L-arginine. In areas with inflammation, large quantities of NO exist. In healthy amounts this leads to the removal of organisms causing the inflammation. However, these can become toxic over time, such as with chronic inflammation. Prolonged high concentrations of nitric oxide can lead to tissue damage.
In one study it was found that the reduction of inducible nitric-oxide synthase was due to transcriptional inhibition.This study showed that the supplementation of SJW could help to treat chronic inflammatory conditions, such as chronic stress.
How Much to Take: For those with depression an initial dose would be 300 mg three times daily. Following this initial dose, most will decrease to 300 to 600 mg daily. St. John’s Wort can interfere with a number of different medications, including but not limited to birth control pills, antidepressants and blood thinners, so be sure to talk to your doctor if you are currently on any medications.
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