3 Fat Storing Hormones You Didn’t Know About
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there are three hormones that will make you store fat we’re talking directly into that cell three things that’ll make you gain fat insulin is one of them but I’ve got two other pretty unique ones that you probably haven’t heard of before and when you know exactly what they are it’s gonna reframe how you look at your overall diet so listen carefully and please do not skip through this video because you have to understand the entirety of it for everything to click and we’re tuned into the Internet’s leading performance nutrition and fat loss channel with new videos Tuesday Friday and Sunday at 7 a.m. Pacific time and a plethora of other videos throughout the rest of the week as well make sure you hit that red subscribe button and then please hit that funky little bell icon that way you turn on notifications be part of the notification squad and know whenever I post a new video or go live alright let’s get going the first one is one that you know of doesn’t really need much of an explanation it’s insulin but let’s break it down a little bit more because I feel like insulin gets a bad rap as being the only fat storing hormone it’s not necessarily a fat storing hormone but it is the absorptive hormone in general okay it’s the job of insulin to tell our cells to open up and be receptive to whatever nutrients are floating through the bloodstream so if insulin is elevated if insulin is on the cells are there with wide open arms to absorb whatever is floating through the bloodstream good bad or ugly okay so insulin can be our best friend but insulin can also be our worst enemy if we eat a bunch of carbohydrates and we spike our insulin and then we consume a bunch of fat too then that fats gonna shut already opened or that insulin opened okay so that’s why insulin can be bad but insulin is not the end-all be-all so let’s not waste a lot of time on that let’s talk about the two more unique ones but more importantly let’s talk about how you can get around this issue overall the next one I want to talk about is something called a SP oscillation stimulating protein this is a really unique one it’s the job of a SP to essentially synthesize triglycerides okay triglycerides are the storage form of fat so when you consume fat believe it or not you do actually store a good chunk of it if you are at least in a caloric surplus so yes that means even if you’re on keto if you overeat your fats then yes those fats can get stored as fat relatively easily and it’s because of this ASP this oscillations stimulating protein I’m just gonna refer to it as ASP from now on but this ASP does indirectly also trigger an insulin spike you see when we eat fats we release a SP + ASP but in the process this ASP also spikes insulin just like a carb would so even though fats don’t turn on insulin fats turn on a SP which then travels and walks down the road and turns on insulin itself so indirectly we do spike our insulin and store fat just by eating fat but there’s another unfortunate side effect of an ASP spike when we consume fat and we spike our ASP we down regulate what’s called lipolysis within a cell when we down regulate lipolysis that’s a fancy way of saying we turn off fat-burning inside the cell so we turn fat storage on and we turn fat-burning off okay now again this goes away with time and it really only plays a big effect if you’re in a caloric surplus so if you’re just you know it’s still in a deficit and you’re still losing weight it’s not gonna play a big role but it’s important that we know which leads me into the next one this one is called GIP glucose dependent insulin atrophic peptide now GIP is also related with fat so when we consume fat we have a GIP spike this GIP spike occurs it’s epicenter in our small intestine so our upper intestinal tract we consume fat our small intestine recognizes it and it triggers this GIP and it’s the job of this GIP to go again and tell fat to be stored in a specific area but it is a little bit more short-term see a GIP only really has an effect for about seven minutes within the body so if you are already in a caloric surplus let’s say you’ve already eaten more calories than you should at a given point in time then you overeat on the fats well that’s when GIP is gonna be a problem so it’s like specifically when you’re overeating now GIP also has a big role in conjunction with hyperglycemia so what that means is GIP becomes a big problem when glucose is also high so when you’re combining fats and carbs is when GIP causes you to store fat so it looks something like this you consume fat it spikes GIP GIP makes you store fat okay that’s not good but if you consume carbs you also spike GIP but when you consume fats and carbs you have a double spike of the GIP because you have fat spiking GIP then you have carbs spiking GIP but you also have carbs already spiking insulin like they’re supposed to so forget all the complexity of this for a second and just take my word for it if you overeat the fats it’s going to cause you to store fat okay you can’t just have ton of fat and expect it to turn you into a fat-burning machine it’s not that simple like a lot of honestly the keto zealots out there will tell you it is there is a way that you can get around this a little bit though omega-3s are very unique okay so if you get your fats from good quality meat sources or good quality fish you’re not gonna have as much of this issue that potentially means that you can over eat a little bit more have a little bit more flexibility if you’re eating higher-quality food so for example omega-3s don’t store as fat nearly as much as other fats do omega-3 excess ends up contributing to the phospholipid bilayers so we’re talking about like cell membranes and things like that because Omega threes have more of a cellular function rather than a storage function within our body so you don’t need to just pop a bunch of omega-3 capsules you just eat high quality sources of food and for those of you that know my channel know that I’m a huge fan of butcher box so if you want good organic grass-fed grass-finished beef and grass finish meat in general that is high in omega 3’s naturally delivered right your doorstep you’re gonna wanna check them out down in the description the cool thing about butcher box it is legitimately grass-fed and grass finish and studies have shown that grasping US beef has significantly higher amounts of omega-3 in it we’re talking a huge difference between normal beef so if we get meat that has high omega-3s we can eat more of it without the potential of it getting stored as fat so again butcher box delivers it right to your doorstep cheaper than the grocery store so make sure you check them out they’re a huge sponsor of this channel and there’s special discounts for anyone that watches my videos so take advantage of it okay let’s break this down a little bit more though when we look at how carbs store as fat we realize that carbs themselves aren’t causing us to really gain fat directly carbs don’t turn into fat super efficiently there is a process within the body called de novo Lupo Genesis where carbs get turned into fat but it’s actually a pretty inefficient process you think about it from a like a legitimate standpoint it doesn’t make a whole lot of sense why it takes a lot of effort to turn a starch into a completely different compound and turn it into fat it does happen but it’s complex so here’s an interesting study that breaks it down and puts it into some simple terminology so the American Journal of Clinical Nutrition published a study that took a look at a few women now with this study they took a 96 hour perio
d of time where they overfed these test subjects okay they overfed them by 50% basically they just gave them a little bit extra food predominantly in the way of carbohydrates what they found at the end of this 96 hour period is there is on average a 282 gram increase in body fat okay now only four grams of that body fat came from de novo lipogenesis what that means is that even though they gained 282 grams of body fat only four came from carbs the other 278 came from somewhere else come through came from something else so what that’s telling us is that even when we overeat it’s not the carbs themselves that get stored and cause the issue carbs might have an indirect effect by spiking insulin but we’re not overeating the carbs and the carbs are making us fat the carbs are just a catalyst it’s a lot easier to store excess fat again let me explain it like this if you overeat and you overeat a bunch of carbs those carbs might mess you up and that’s gonna suck but those extra carbs are less likely to get stored as fat than excess fat is because dietary fat that you consume is already molecular Li so similar to a storage form of fat that it just makes sense for it to store it so much easier whereas glucose or carbs are already broken down into fuel why would our body store that when it’s complicated to store it when it can just burn it it just it’s gonna store the excess fat because it’s a lot easier to store it so again with great power comes great responsibility you’re eating a lot of fats okay that’s great it’s good for your brain it’s good for your it’s good for your physique but don’t overdo it okay you still have to keep it within control it’s not just fair game to eat however much fat you want and if you are gonna eat fat you are going to go to town at least try to get some good quality meat in the process as always to make sure you came out locked in here in my channel I’ll see you in the next video
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3 Fat Storing Hormones You Didn’t Know About – Thomas DeLauer
Insulin is a fat storing hormone because it increases the major fat storing enzyme in the body called lipoprotein lipase (LPL)
It also decreases hormone sensitive lipase (HSL), the major fat burning enzyme
Aside from insulin, there are 2 other fat storing hormones:
Acylation Stimulating Protein (ASP)
ASP is a hormone produced by adipocytes that’s produced through a process involving three proteins: C3, factor B and adipsin, which are secreted by adipocytes – it’s an adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes
ASP has a primary role in the regulation of lipid metabolism in adipocytes, where it stimulates glucose uptake, increases the activity of diacylglycerol acyltransferase, and inhibits hormone-sensitive lipase activity
In cellular studies, ASP increases fat storage through increased triglyceride synthesis and decreased intracellular lipolysis
Glucose-dependent insulinotropic peptide
A hormone released from the small intestine that enhances the release of insulin following the intake of food.
Glucose-dependent insulinotropic peptide is made and secreted mainly from the upper section of the small intestine from a specific type of cell known as the K cell
Its main action occurs in the pancreas where it targets beta cells, which produce insulin. Glucose-dependent insulinotropic peptide stimulates the release of insulin from the beta cells in the pancreas in order to maintain low blood sugar levels after eating.
The main trigger for glucose-dependent insulinotropic peptide release is food, in particular fatty foods or those foods that are rich in sugar.
Once released into the bloodstream, levels of glucose-dependent insulinotropic peptide do not remain high for very long. It is broken down quite quickly (after about seven minutes) and therefore does not remain in the circulating blood for long.
Fat vs Carb Storage
There’s a process in our body that makes gaining fat from carb consumption very difficult – that process is called De Novo Lipogenesis
A recent study on overfeeding via carbs looked at this:
Study – The American Journal of Clinical Nutrition
De novo lipogenesis was measured during 96 hours of overfeeding by 50% with either sucrose or glucose and during an energy balance treatment (control) in 8 lean and 5 obese women
De novo lipogenesis was 2- to 3-fold higher after overfeeding by 50% than after the control treatment in all subjects
The type of carb overfeeding (sucrose or glucose) had no significant effect on de novo lipogenesis in either subject group
They found that the carb-overfed women stored about 282 grams of body fat per day, but only 4 grams of it came from de novo lipogenesis
De novo lipogenesis accounted for only 1.4% of their fat gain
The 278 grams of fat per day that the women gained from dietary fat
Omega 3’s & Fat Gain
If you are eating excessive amounts of DHA or EPA, these fatty acids are more likely to be incorporated into phospholipid bilayers than adipose tissue
The abundance of EPA and DHA in human subcutaneous adipose tissue is low, typically less than 0.2 for EPA and up to 1.0 mol% for DHA
This suggests that EPA and DHA are not preferentially stored in adipose tissue triacylglycerol long-term, rather they may be partitioned to oxidation pathways or to storage in other lipid fractions, such as phospholipids; red blood cell and plasma phospholipids have a notably higher abundance of both EPA and DHA than adipose tissue
After EPA and DHA are consumed through the diet, they are placed within a membrane phospholipid, where they can affect cellular function by promoting the fluidity, flexibility, and/or the permeability of a membrane
Omega 3’s & Fat Loss
A study of 44 people reported that those given 4 grams of fish oil per day failed to lose more weight than those given a placebo.
However, the fish oil group lost 1.1 more pounds (0.5 kg) of body fat and built 1.1 more pounds (0.5 kg) of muscle than those not given fish oil
Fish oil intake induces UCP1 upregulation in brown and white adipose tissue