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Signs that You Have Chronic Inflammation – Thomas DeLauer
Special Thanks to my team and Nicholas Norwitz – Oxford Ketone PhD Researcher and Harvard Med Student – for working diligently on research as well!
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Inflammation is critical. It’s critical to our recovery, it’s critical to fighting pathogens, and it’s critical to so many other things. So let’s look at our inflammation system like the army. It’s a hierarchy of soldiers, of communication devices, and weapons. And let me explain it in a very simple breakdown.
Your white blood cells, these are the soldiers. So in the hierarchy of the inflammation system, the white blood cells are the soldiers. They are the cells that go out and actually do the fighting. So when you have an infection, your white blood cells go up.
In fact, here’s an interesting study that was published in Acta Physiologica. It took a look at 18 to 35 year old test subjects, and divided them into two groups. One group, they had consumed 1200 milligrams of ibuprofen as an antiinflammatory, and the other group did not.
Well then they had them do weight training for eight weeks. And then they did some MRI testing at the end of the weight training sessions at the end of the eight weeks. And they found that the group that took the ibuprofen had half as much muscle as the group that didn’t take the ibuprofen, in terms of the growth.
They didn’t lose muscle. But the ibuprofen group didn’t gain muscle, and the non ibuprofen group did, showing that by stopping the inflammation, the stress response didn’t allow the muscle to grow.
Then there’s a couple of other things that we need to look at to understand inflammation. We have what is called nuclear factor Kappa B. Again, sounds complicated and it is, but what it is is a transcription factor.
So remember the army that I talked about, well nuclear factor Kappa B is like the war plan. It’s like you were to roll out just, this is our agenda, this is our whole war plan. It’s the top secret classified documents. Now this nuclear factor Kappa B is the plan and the classified documents that tell the inflammation where to go.
So if this number gets elevated, then that means that we have a lot of different plans out, and it means that the system is having a lot of different wars going on throughout the entire body. It’s got a war on your kidneys, a war on your liver, a war on your blood, a war on your brain, boom, all kinds of different transcriptions out there. So that’s another one we have to look at.
So the way that we can look at it within this simple hierarchy of the soldiers, again, NLRP3 inflammasome is like the White House, or it’s like the political leaders that dictate what is going to happen within the soldier hierarchy.
So if we have NLRP3 inflammasome that’s elevated, then we have, basically, a lot of different delegation that’s going on, sending a lot of different troops to war. So we don’t want this number to be high because this is the ultimate epicenter that trickles down to what the inflammation system is going to do. So if this number is high, we have a problem. So this is the number you really want to look at.
What’s interesting, and this isn’t just something super, super contrived, but there was a study that was published in the Journal Nature Medicine in 2015 that found that beta hydroxybutyrate, which is the main ketone when you’re in ketosis, actually blunts NLRP3 inflammasome. So it stops it from forming.
This is really crazy stuff. Now, the interesting thing is, is that these ketone bodies don’t just block the inflammasome, they actually stop the inflammasome from ever really coming to fruition because they block the flow of potassium ions.
Nicholas Norwitz – Oxford Ketone PhD Researcher and Harvard Med Student: