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calling all people who eat a lot at one sitting calling all people that do the one meal a day diet calling all people that even intermittent fast and calling all people that just have a tendency to allocate most of their calories to one meal you’re gonna want to pay very close attention to this video because it finally gives some serious justification as to why even if we’re fasting we may want to break our meals up just a little bit you are tuned into the Internet’s leading performance nutrition and fat loss channel new videos on Tuesday Friday and Sunday at 7 a.m. Pacific time and a bunch of other videos throughout the week please hit that subscribe button then also make sure you hit that Bell button to turn on notifications so you know whenever I go live or post brand spankin new content also make sure you check out thrive market down in the description hey thrive market is a place where you can get all of your groceries we’re talking things like just your snacks your keto snacks you’re fasting foods you’re fasting teas things like that all available at the right market and I have specific thrive bundles that I’ve created so specific groceries that I would normally eat thrive makes it so that you can get your groceries delivered right to your doorstep don’t have to go to the grocery store and in the process save a bunch of money so huge fans of them and again you can check out my keto bundle you can check out my fasting bundle all groceries that I recommend so check them out down in the description after we finished up with this video okay so here we go I’ve never been a huge fan of eating a bunch one sitting it’s kind of been my internal battle with some of the intermittent fasting world and some of the one meal a day world now I’m not saying that one meal a day is bad or I’m not saying that intermittent fasting is bad heck I fast heck I do one meal a day sometimes but I’ve always felt that there is a little bit of a problem with trying to consolidate all of your calories into one sitting or eating too much at one sitting so what’s interesting is there’s now a study published in the journal Cell that found that there is a serious link between overeating at one sitting and the overall effect on slowing down our metabolism ok so this study took a look at something that is known as an iron our dependent protein kinase okay we’re gonna call it PK r cuz that’s the acronym for it for short okay so it’s a specific protein that is involved in our immune system now this is excite it shows that overeating in one sitting literally can shut down our metabolism what this study found was that this simple PKR the simple thing it’s job is to normally find viruses so normally we’ll do is be like oh we got a cold virus coming in PKR needs to go in attack in organized an attack okay so we used to think that PKR only had an effect on our immune system and fighting viruses but now studies are showing that PKR turns around and fights our metabolism when we overeat yeah literally so this thing that used to only specifically fight viruses actually turns to on us and fights our metabolism if we need too much so basically when we eat a normal-sized meal PKR is silent it does what it’s supposed to do it hangs around and waits for a real threat right it waits for a virus but when we overeat and we bombard ourselves with a bunch of nutrients at once it triggers PKR to organize an attack because we’ve bombarded our body with so many nutrients at once that it sees it as a threat so it organizes a firing squad to eliminate the threat it organizes a firing squad to shut down our metabolism basically it triggers an autoimmune response on the entirety of our metabolism to protect ourselves we aren’t designed to overeat at one specific time we’re not designed to eat 3,000 calories in one sitting because this PKR now says this is not normal we need to fight this and shoot this down so this leads to insulin resistance at least a metabolic syndrome a bunch of other issues every now and then is one thing but if you’re consistently overeating you need to do whatever you can to split out into two meals if you’re intermittent fasting have a small meal then have a dinner then have a medium-sized meal just consolidate but don’t allocate them all to one meal okay so this whole thing is being dubbed as a meta flow Meishan okay it’s early on it’s in the embryonic stages but when we start seeing a lot more of it now full disclaimer this study in journal Cell was done on mice and I have no problem admitting that because I have enough of a clinical background and know that although Studies on mice are not directly apples to apples they have a lot of Merit which why we do them okay myself PK are humans have PK are so this whole meta Flemming he’s a serious deal so what this study actually did is it took mice that had PKR in their system and then it took mice that did not have PK are okay and they had both groups over eat the same amount they had to just eat a bunch the mice that had PK are ended up gaining a bunch of weight and became obese the mice that did not have PK are even though they over ate the same amount they didn’t gain nearly as much weight and did not become obese first thing that comes to my mind is how can I just eliminate PK r out of my system the fact is we’re not there yet the reality is that PK r does have a big effect on us storing more fat simply because it halts our metabolism we are literally instigating an entire immune response ourselves when we eat too much in one sitting and I’ve realized this firsthand I notice whenever I do that I don’t feel too great now again it’s not here to shoot down one meal a day the fact is a lot of people have success with one meal a day I do however thing that you may want to do it in intervals not all the time okay if your overall calories in are less when you do one meal a day and it would be otherwise you will probably lose weight but you don’t want to trigger systemic inflammation because that is a bad road to go down for the long term one meal a day maybe one or two days per week okay I understand it feels good and I’m not trying to shoot it down a lot of my followers do this but try to go to meal a day or try to even go three meal a day and just consolidate it into a small window space it out we don’t need to eat it all at one just trying it sitting okay inflammation bad as always keep it locked in here my channel see you in the next video
This Post Was All About Overeating after Fasting = Fat GAIN.
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Overeating after Fasting = Fat GAIN – Thomas DeLauer
A study published in the journal Cell found that overeating has a harmful effect on the body’s metabolism – it may destroy your body’s regular metabolic response
In your body there is a molecule called RNA-dependent protein kinase, or PKR, which points out and fights viruses with other molecules, but if you overeat, it also attacks metabolism
When you eat too much, excess nutrients attack cells that contain PKR, and its response is to fight back by shutting down metabolism because all of these extra nutrients are perceived as a threat
This can lead to metabolic disorders such as diabetes and obesity.
Note: Although the study was performed on mice, researchers stated that it gives them a better understanding of PKR and the side effects of overeating
More In Depth
Overeating in mice triggers a molecule once considered to be only involved in detecting and fighting viruses to also destroy normal metabolism, leading to insulin resistance and setting the stage for diabetes
When mice eat a normal diet, this molecule called PKR is silent; however, if a cell containing PKR is bombarded with too many nutrients, PKR grabs other immune system molecules that respond to this food attack and organizes a “firing squad” to shoot down normal processes, leading to insulin resistance and metabolic dysfunction
The results provide evidence that a process called “metaflammation” occurs in the body – metaflammation is inflammation triggered by the metabolism of nutrients that occurs when the body processes food into energy
It’s known that nutrients can be detrimental in excess quantities or when they are in the wrong place at the wrong time, but what isn’t as clear is which paths they travel through that result in harm and produce inflammation
PKR is a mechanism by which nutrients – necessary and beneficial under normal conditions – cause damage to cells and organs.”
The researchers used sets of mice in their experiments: One set had PKR in its bodies, and the other set did not
The researchers then overfed a group of PKR-positive and PKR-negative mice high-fat, high-calorie diets
The overfed mice with PKR became obese and developed insulin resistance, while the overfed mice without PKR gained significantly less weight and did not develop insulin resistance, indicating that absence of PKR can alleviate harmful metabolic effects due to overeating in mice
Overeating & Brain Function
Brain insulin is what suppresses lipolysis, a process during which triglycerides in fat tissue are broken down and fatty acids are released
When lipolysis is unrestrained, fatty acid levels are elevated
Once you overeat, your brain develops insulin resistance – since brain insulin controls lipolysis in adipose tissue by reducing sympathetic nervous system outflow to adipose tissue, brain insulin resistance causes increased spillage of fatty acids from adipose tissue into the bloodstream
In this study, published in the Journal of Biological Chemistry, researchers fed rats a high-fat diet composed of 10% lard for three consecutive days
This increased their daily caloric intake by up to 50% compared to the control rats that were fed a regular low fat diet
The researchers then infused a tiny amount of insulin into the brains of both groups of rats that they had shown in earlier studies to suppress release of glucose from the liver and fatty acids from fat tissue
They found that overeating impaired the ability of brain insulin to suppress glucose release from the liver and lipolysis in fat tissue