Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer

Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer

Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer

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I want to talk about some of the hormones that are responsible for tissue growth responsible for muscle growth but I also want to address some of the pressure that you might be feeling from the industry and sometimes even from your doctor when it comes down to human growth hormone or IGF hey you haven’t already I want to make sure you hit that subscribe button so you get videos every single Tuesday Friday and Sunday at 7 a.m. Pacific time and always make sure you check out highly calm so you can check out the apparel that I’m wearing as well okay so let’s get down to the science of this human growth hormone and igf-1 within the body and what I mean by that is they do very similar things but at the same time they’re also very very different so what happens is your pituitary gland creates something called human growth hormone this human growth hormone circulates throughout the course of the body and eventually hits the liver when it hits the liver it triggers the release of something known as IGF insulin-like growth factor-1 so the first misnomer that we have to address when we’re looking at human growth hormone we’re looking at muscle growth in general is that human growth hormone doesn’t directly allow muscles to grow human growth hormone indirectly activates IGF which therefore allows muscles to grow through a couple of different pathways you see not only do we create insulin-like growth factor in the liver we also create it at different localized areas throughout the body in the skeletal muscle and in the bone so that’s exactly why hormonal e your body starts to build muscle when you train a specific area so when we look at things like this it would be easy to assume that if we utilize human growth hormone we’d be able to produce more muscle but let’s understand how this works a little bit more you see human growth hormone is usually secreted through periods of growth naturally okay so whenever your body biologically feels that it needs to grow adolescence is a perfect example you’re gonna be secreting human growth hormone in a pulsatile fashion and you’re usually secreting it throughout the evening time or through the night time when you’re asleep you’re also going to secrete it when you’re consuming copious amounts of protein at one sitting simply because the amino acid arginine but you’re also going to stimulate it through intense exercise so first off we have to understand when the body is producing it and that helps us understand when you would actually need it so believe it or not it’s being discovered in a lot of studies that unless you’re deficient in human growth hormone you’re not going to get much benefit out of adding it in to your body now we’re gonna address the human growth hormone side of things a little bit more we look at some of the studies later in this video but first let’s talk about what i GF is and how this process works you see most of the anabolic responses that were getting from human growth hormone again aren’t a result of human growth hormone there were a result of IGF so let’s talk about IGF c IG F stands again for insulin like growth factor and what that means is it’s very very structurally similar to insulin now if you’ve watched my other videos you know that insulin is the absorptive hormone okay it’s the hormone that turns your body into absorptive mode meaning it’s easier to store carbohydrates and it’s easier to store fat and ultimately even easier to store a little bit of muscle – now because insulin like growth factor is a lot like insulin it has the ability to turn muscle cells into a very very hungry state meaning they’re able to take in protein increased protein synthesis and ultimately increase muscle that’s the benefit of insulin like growth factor and of course it’s precursor being human growth hormone so what happens is after the human growth hormone triggers the liver to produce IGF this IGF binds to insulin-like growth factor binding protein and it circulates throughout the body and then it reacts with another protein that allows it to get into specific cells or cross through the blood-brain barrier to actually grow your brain as well so it’s a very complex system it’s not quite as simple as human growth hormone just immediately causing you to gain more muscle it’s a lot more complex than that you see some of the other ways that IGF actually allows you to boost muscle from a hormonal standpoint from an enzymatic pathway has to do with something known as protein kinase B okay a KT this is a specific pathway that IGF triggers and this specific pathway triggers protein synthesis so it’s doing this through a different mechanism and it does this by eliciting a response on what is called the mammalian target of rapamycin maybe you’ve heard of mTOR before mTOR is literally the anabolic switch so you can have all the IGF in the world but your muscle is not going to grow if the imports which is not flipped on see mTOR equals anabolism no mTOR equals catabolism or at least no muscle growth so without the anabolic switch turned on i GF doesn’t necessarily grow muscle but it can grow tumors that’s definitely not a good thing so why do we hear so frequently from so many doctors and from so many other resources that we should be utilizing the exhaustion Asst human growth hormone as we get older I mean it kind of makes sense at first we’re getting older so our levels are declining but are they truly declining and are we truly in a deficient state or they declining at the age at which they should be declining and you’re having other hormones balancing things out well I’m gonna reference a couple of studies but at the end of the day a lot of it is showing that it’s just the lipolysis the fat burning effect of human growth hormone an IGF that is causing people to get a little bit confused and think that they’re building muscle when in reality they might just be getting a little bit leaner which of course is a good thing but we have to look at the big equation and whether it’s worth it when you look at the cost benefit and risk analysis so this first study was published in the American Journal of physiology and it took a look at test subjects that were clearly deficient in human growth hormone so it took a look at older women so we’re talking like 64 to 82 years old we’re talking like an older demographic of women that are severely deficient in human growth hormone and what they did is they measured some levels after they give him either human growth hormone or low medium or high doses of insulin like growth factor and they gave this to them every week and they measured it over the course of a period of time and what they found at the end of the study was that yes these women that were deficient in human growth hormone had an increase of 9% in overall protein synthesis as associated with the HGH and a four and a half percent increase in protein synthesis associated with the IGF so yes there was an increase in protein synthesis in fact when they measured protein synthesis by concentration of leucine they actually found that there was a 50% increase in protein synthesis with HGH and a 67 percent increase in protein synthesis with IGF what the heck does this mean okay all that this truly means is that women that were deficient saw an increase in protein synthesis now these are the kind of studies that are always out there they take these studies with people that are deficient in something they give them an exogenous form of something and they say voila look we fixed everything the reality is these people were too efficient in something so what we are looking at it as performance people and as people they’re trying to better ourselves and get an amazing shape and stay healthy we have to look at some of the other science that looks at it from a different perspective so here’s what’s funny when we look at the other side of the equation the same journal American Journal of physiology published a study looking at healthy adults that had healthy levels normal levels of human growth hormone igf-1 shch and they wanted to measure their overall levels of protein synthesis and what actually happened well guess what no change the only change that occurred in those that took the exoticness HGH was a small increase in net amino acids in their forearm yep they measured a few more aminos in their forearm that was the only difference when human growth hormone levels were already at their normal state but there was another study that was published in JMA that took a look at this as well and they found that again older men that had healthy normal levels of human growth hormone for their age saw no change in terms of muscle mass and strength when utilizing exogenously min growth hormone but those that wait trained did see a change so if you took those that were utilizing exogenously h along with weight training yeah they saw a change in muscle mass and strength but those that were not utilizing HGH but also weight reigned saw an increase in muscle mass and strength so you have to ask yourself where do you want to go with this now the studies are proving that there is in the increase in lipolysis meaning a small increase in fat burning but there are also studies they’re showing there is an increase in collagen synthesis with human growth hormone so what can be happening is people can be seeing an increase in their collagen levels which means their connective tissues a bit stronger which means their muscle contractile strength is a little bit more they can handle a little bit more so any increases in strength could be attributed to that but changes in physique and appearance are likely due to skin and likely due to lipolysis the increase in fat burning so what we have to do is we have to look at the increase of insulin-like growth factor that occurs from exogenous HGH use and how it has an effect on tumor growth and other tissues that we don’t want to grow and we have to weigh the pros and cons if you’re at the age where your doctor is pressuring you is it something that you want to do you need to do your due diligence and truly look at this because when we look at how the body works we truly have to capitalize on what it is doing in its own natural state at its own very point in time so my honest humble opinion is exercise hard until you can’t exercise hard anymore because exercise is one of the most powerful natural ways to stimulate human growth hormone outside of of course sleeping and the occasional intermittent fasting so as always make sure you’re keeping it locked in here on my channel I know this video wasn’t one-sided it was kind of a big overview but if you like more on this topic and you want to hear a little bit more about how these things work in the body just put them down in the comment section below and we can decide on what videos to do next I’ll see you in the next one

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Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer

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Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer…. I want to talk about some of the hormones that are responsible for tissue growth, responsible for muscle growth, but I also want to address some of the pressure that you might be feeling from the industry and sometimes even from your doctor when it comes down to human growth hormone or IGF. Human growth hormone and IGF are two very, very similar hormones within the body, and what I mean by that is they do very similar things, but, at the same time, they’re also very, very different.

What happens is your pituitary gland creates something called human growth hormone. This human growth hormone circulates throughout the course of the body and eventually hits the liver. When it hits the liver, it triggers the release of something known as IGF, insulin-like growth factor-1. The first misnomer that we have to address when we’re looking at human growth hormone and we’re looking at muscle growth, in general, is that human growth hormone doesn’t directly allow muscles to grow. Human growth hormone indirectly activates IGF, which, therefore, allows muscles to grow through a couple of different pathways.

You see, not only do we create insulin-like growth factor in the liver, but we also create it at different localized areas throughout the body, in the skeletal muscle and in the bone. That’s exactly why, hormonally, your body starts to build muscle when you train a specific area.

When we look at things like this, it would be easy to assume that if we utilized human growth hormone, we’d be able to produce more muscle, but let’s understand how this works a little bit more. You see, human growth hormone is usually secreted through periods of growth, naturally, whenever your body biologically feels that it needs to grow. Adolescence is a perfect example. You’re going to be secreting human growth hormone in a pulsatile fashion, and you’re usually secreting it throughout the evening time or within the night time when you’re asleep, but you’re also going to secrete it when you’re consuming copious amounts of protein at one sitting, simply because of the amino acid arginine, but you’re also going to stimulate it through intense exercise.

First off, we have to understand when the body is producing it, and that helps us understand when you would actually need it. Believe it or not, it’s being discovered in a lot of studies, that unless you’re deficient in human growth hormone, you’re not going to get much benefit out of adding it into your body.

We’re going to address the human growth hormone side of things a little bit more when we look at some of the studies later in this video, but, first, let’s talk about what IGF is and how this process works. You see, most of the anabolic responses that we’re getting from human growth hormone, again, aren’t a result of human growth hormone. They’re a result of IGF. Let’s talk about IGF. You see, IGF stands again for insulin-like growth factor, and what that means is it’s very, very structurally similar to insulin.

If you’ve watched my other videos, you know that insulin is the absorptive hormone. It’s the hormone that turns your body into absorptive mode, meaning it’s easier to store carbohydrates and it’s easier to store fat and, ultimately, even easier to store a little bit of muscle, too.

References:
1) Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. (n.d.). Retrieved from

2) Claims for the anabolic effects of growth hormone: a case of the Emperor’s new clothes? (2003, April 1). Retrieved from

3) Butterfield GE , et al. (n.d.). Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women. – PubMed – NCBI. Retrieved from

4) Growth Hormone Therapy for the Elderly: The Fountain of Youth Proves Toxic. (1993, October 13). Retrieved from

5) Role of microRNAs in skeletal muscle hypertrophy. (n.d.). Retrieved from

6) Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. (n.d.). Retrieved from

7) Fryburg DA , et al. (n.d.). Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. – PubMed – NCBI. Retrieved from 2

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