More Protein COULD Be GOOD on Keto – Energy Hypothesis

More Protein COULD Be GOOD on Keto – Energy Hypothesis

More Protein COULD Be GOOD on Keto – Energy Hypothesis

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I’m gonna demonstrate something for you hey Neeson you got some money for me ah all right six dollars okay you gave me six dollars so I’m gonna give you back two seems fair right someone’s giving me six dollars I just give him two bucks back right well what I’m getting at here is how the process of turning protein into sugar works okay specifically when we’re talking about the ketogenic diet and gluconeogenesis everyone out there is afraid that extra protein is going to kick them out of keto and you’re gonna ruin everything well I want to flip that on its head and explain to you why gluconeogenesis in the process of turning protein into carbohydrates actually helps you lose weight hey you’re tuned into the Internet’s leading performance nutrition and fat loss channel new videos every single Tuesday Friday and Sunday at 7 a.m. Pacific time and a bunch of other videos throughout the week as well please hit that little subscribe button so you know whenever I’m posting videos but also hit that Bell button so you never miss any beats at all that way you can always be here with my live broadcast and heck you might even get $2 now if you like good quality meat then you’re gonna want to check out butcher box after you watch this video so you have a special link down in the description that gets anyone that’s watching this video or anyone that’s a fan of mine a special discounted price on high-quality grass-fed grass-finished meat but also pasture-raised chicken and good quality wild-caught fish as well so it’s all down below in the description and guess what is cheaper than the grocery store so big thank you to them make sure you check them out but first let’s watch this video all right so what the heck is going on what am I talking about here gluconeogenesis is something very simple okay it’s the process in which your body takes protein and converts them into carbohydrates and it has a lot of people running for their lives scared that eating too much protein to kick them out of keto and I’ve addressed that in another video but I want to explain how it actually helps you burn more fat and this is something that I’ve learned recently and I’m a believer in now because I wasn’t even a believer in this a year ago okay it’s simple the process of creating carbohydrates from protein is metabolically very expensive so what that means is on average we four or five hundred calories per day just converting protein into carbohydrates it’s a metabolically expensive process that’s a good thing so here’s where the $6 and $2 thing comes into play okay it costs six ATP ATP is energy so in this case its currency its energy currency it costs us six ATP to turn protein into a carbohydrate that carbohydrate then only yields two ATP through a form of glycolysis simply put all that means is that we spend six units of energy converting a protein to a carb which ultimately only gets us two units of energy we have a net loss of four ATP so when Neeson gave me six dollars and I gave him two back he walked away with four dollars less in his pocket than he did when he came to me so he had a net loss okay that’s the same way gluconeogenesis works we actually pay more energy money to create a carbohydrate from protein than we actually get in return so go for it take that protein and convert it because that’s basically four units of ATP that’s running on a treadmill inside my body that I never have to lift the foot over it’s just burning up energy burning fat burning calories gluconeogenesis is not bad but let me add one more thing it’s demand-driven and you’re only gonna use it when you need it so don’t freak out about it embrace it it’s inefficient and it’s any efficiency that drives the totally messed up economy of our insides which helps us burn fat so as always keep it locked in here on my channel if you have ideas for future videos you know where to put them

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More Protein COULD Be GOOD on Keto - Energy Hypothesis

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More Protein COULD Be GOOD on Keto – Energy Hypothesis – Thomas DeLauer


A study published in the American Journal of Clinical Nutrition looked at the effects of gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet

Wanted to see whether a high-protein, carbohydrate-free diet (H diet) increases gluconeogenesis and whether this can explain the increase in EE (energy expenditure)

10 healthy men received a high protein, low carb diet (30%, 0%, and 70% of energy from protein, carbohydrate, and fat, respectively) or a normal-protein diet (12%, 55%, and 33% of energy from protein, carb, and fat, respectively) for 1.5 days

Endogenous glucose production (EGP) was lower in the high protein, low carb group than in the normal protein, higher carb group

But researchers found that there was a 42% of the increase in energy expenditure after the high protein, low carb diet, explained by the increase in gluconeogenesis – the cost of gluconeogenesis was 33% of the energy content of the produced glucose

Concluded: With the high protein, low carb diet, the contribution of increased gluconeogenesis to increased energy expenditure (EE) was 42%

Although other energy-requiring pathways in protein metabolism, such as protein synthesis, may contribute to the increase in EE after a high-protein diet, the results of the study showed that gluconeogenesis contributes to a major part (42%) of the increased EE

Gluconeogenesis and Your Liver

As mentioned, the process of gluconeogenesis takes place primarily in the liver, where glucose is made from amino acids (protein), glycerol (the backbone of triglycerides, the primary fat storage molecule), and glucose metabolism intermediaries like lactate and pyruvate

Lactate is produced by a breakdown of muscle tissue and sent to the liver through the bloodstream – at night, when we haven’t eaten for several hours, the body begins to manufacture glucose using gluconeogenesis – works in 3 steps:


1) The conversion of pyruvate to PEP is regulated by acetyl-CoA. More specifically pyruvate carboxylase is activated by acetyl-CoA. Because acetyl-CoA is an important metabolite in the TCA cycle which produces a lot of energy, when concentrations of acetyl-CoA are high organisms use pyruvate carboxylase to channel pyruvate away from the TCA cycle. If the organism does not need more energy, then it is best to divert those metabolites towards storage or other necessary processes.

2) The conversion of fructose-1,6-bP to fructose-6-P with the use of fructose-1,6-phosphatase is negatively regulated and inhibited by the molecules AMP and fructose-2,6-bP. These are reciprocal regulators to glycolysis’ phosphofructokinase. Phosphofructosekinase is positively regulated by AMP and fructose-2,6-bP. Once again, when the energy levels produced are higher than needed, i.e. a large ATP to AMP ratio, the organism increases gluconeogenesis and decreases glycolysis. The opposite also applies when energy levels are lower than needed, i.e. a low ATP to AMP ratio, the organism increases glycolysis and decreases gluconeogenesis.

3) The conversion of glucose-6-P to glucose with use of glucose-6-phosphatase is controlled by substrate level regulation. The metabolite responsible for this type of regulation is glucose-6-P. As levels of glucose-6-P increase, glucose-6-phosphatase increases activity and more glucose is produced. Thus glycolysis is unable to proceed.


1) Gluconeogenesis. (2016, July 21). Retrieved from

4) Veldhorst MA , et al. (n.d.). Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet. – PubMed – NCBI. Retrieved from 2

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