Ketosis Science: Do Exogenous Ketones Work? Thomas DeLauer

Ketosis Science: Do Exogenous Ketones Work? Thomas DeLauer

Ketosis Science: Do Exogenous Ketones Work? Thomas DeLauer

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so we’re here because we like ketosis and we like ketones but our exhaustion is ketones are really going to help you get the extra edge that you need let’s talk about it for a little bit in this video I want to break down what exactly exhaustion is ketones are how they work in the body when it comes down to potential weight loss how they work in the body when it comes down to energy how they work in the body when it comes down to brain optimization and a couple of other things I want to touch on a quite a few different angles when it comes down to exogenous ketones so you have a full variety of understanding of what’s exactly happening in the body all right so first and foremost for those of you that don’t know what happens with ketone bodies in the body when you are utilizing fuel your body is either using glucose or it’s using fats and when you totally run out of glucose and you run out of muscle glycogen your body switches gears and starts utilizing ketones as a source of fuel that’s how we know we’re in ketosis now the thing is there are things called exhaustion as ketones which are literally those same ketones but just in a nutritional drink or in some kind of executive supplement all exhaustion amines is that you’re getting it from an external source you are also producing these endogenously meaning you’re producing them in your body but if you get them exogenously it means you’re taking a supplement so exhaustion is ketones are just ketones that are put in a bottle for you to drink now the theory is that when you consume these they’re gonna give you a little bit more energy or they might help you get into ketosis so they might do a couple other things well I want to talk about them in detail and what they do well we first have to know is that exogenous ketones are generally speaking beta-hydroxybutyrate beta-hydroxybutyrate is the main ketone body when it comes down to well most research to be honest it’s the most studied and what ends up happening in the body is your body creates beta-hydroxybutyrate from ketones or from fatty acids that beta-hydroxybutyrate then turns into something called a sido acetyl acetate ok this Osito acetyl acetate then goes through another conversion process where it turns into acetyl coenzyme a and actually creates two of those now that’s a lot of science it’s a lot of craziness you may not remember your sophomore year of biology class but basically acetyl coenzyme a is the energy powerhouse it’s the very beginning of the Krebs cycle and very into the Krebs cycle so it’s what we ultimately want to create energy now additionally some of this beta-hydroxy view does get converted into acetone and is excreted through the body this Osito Osito acetate combines with a decarboxylation process which actually creates acetone and excretes it through the body so not all of the ketones that you use are used for fuel a lot of them just get used and excreted out but anyway that’s water under the bridge I just wanted to give you a quick understanding of what made a hydroxy butyrate is now let’s talk about how it works in the body see when your body is not using glucose its utilizing these ketones and when it utilizes these ketones you have a lot more energy per gram than you do coming from glucose so when we’re looking at ketones in theory they should be very very powerful well let’s take a look at how it works when it comes down to weight loss first so a lot of people will argue that taking ketones puts you into a deeper state of ketosis and thereby helps you burn more fat well in some ways that’s true in some ways it’s not what we do have to look at first is that whenever you take an exogenous ketone you’re putting something in front of the endogenous production the endogenous production of ketones is burning your body fat it’s burning your fat stores so when you add an exogenous source to the mix you’re putting something in front of it so you’re possibly slowing the process down now on the other side of the coin what ends up happening is exogenous ketones create what’s called a feedback loop your exogenously putting ketones in the body so when you do remove those ketones your body’s going to be searching for them basically it’s something like this you take exhaust ketones your body says yeah yeah yeah I love running on these ketones and then all of a sudden you take them away your body’s like wait where are the ketones where are they so it starts creating them a little bit faster so it is a way to sort of quote-unquote prime your body to producing more ketones which thereby could in the long term help you lose a little bit more weight but in the short term taking ketones right out the gate might give you more energy but it’s not necessarily causing you to burn more fat now the other thing that we really have to be careful with when it comes down to exogenously tones is understanding glucose metabolism in conjunction with exhaustion is ketones you see studies have shown that when you consume exogenous ketones your body preferentially wants to run on them which means glucose metabolism slows down which sounds like a good thing at first but when you realize what’s happening it’s a little bit sketchy and you have to just make sure that you’re cautious basically look at it like this you just consumed a bunch of carbohydrates you’re ready to workout your body’s about to burn all of those carbohydrates normally that wouldn’t cause an issue because you’re not going to store those carbohydrates they’re gonna be burned for fuel let you decide to take Exantus ketones along with your carbohydrates well since exogenously tones are such an easier fuel to use which is a good thing what kind of a bad thing the body wants to use those instead so now the glucose that you already consumed from the carbohydrates isn’t getting utilized it’s just sitting there so if you consume carbohydrates in conjunction with beta-hydroxybutyrate you could be putting yourself in a situation to store that glucose as fat despite the fact that you’ll have an abundant energy coming from the ketones so you just have to be cognizant of that so case in point is simply that when you use exogenous ketones you’re gonna get the most weight loss effect if you are already in a nutritional state of ketosis not if you’re adding them along with carbohydrates but now it leads me into the next thing I want to talk about which is the brain you see the brain normally utilizes glucose as a source of fuel it’s what it’s designed to run on however ketone bodies are so much smaller there’s such a small molecule they can cross through the blood-brain barrier and get utilized by the brain a lot easier they don’t have a whole lot of processing that gets involved they just provide instant energy so when you’re consuming ketones you do get a big boost in brain performance a huge boost in brain performance but you also have to be cognizant of the fact that again if you’re consuming glucose along with these ketones that glucose is just gonna sit there again you’re gonna feel amazing you’re gonna have tremendous brain performance but you might store that glucose and quite honestly the studies are inconclusive because beta-hydroxybutyrate as an exhaustion of ketone is still so new we’re still waiting on more research to see what really happens with that glucose that’s just sitting there the other thing that’s outed with exhaustion is ketones a lot is that they will help you with the keto flu and in order to make a point of this I have to explain what the keto flu is when you are first transitioning into ketosis a lot of times you feel rundown you feel a little nauseous you feel a little bit sick a little queasy a little bit unlike yourself well this happens for two reasons it could be happening simply because your body is in that transition phase it doesn’t know how to utilize fats yet it’s still utilizing carbs but the other thing is actually the opposite when your body does start producing ketones its producing them inefficiently it’s just producing a ton of them and you actually produce so many ketones that you kind of make yourself sick and you have to burn them off so exhaustion is ketones can help with the keto flu if you’re dealing with the prior situation if you’re in a situation where you’re trying to encourage your body to slowly start utilizing ketones a bit more by adding those ketones into the mix exogenously you stimulate the body to want to use them okay but if you were the other kind of person that’s dealing with the keto flu because you have too many ketones you’ll notice when you add exogenously tones that you feel works now if that’s the case that doesn’t mean exogenous ketones aren’t for you it just means that you have the different kind of keto flu that you shouldn’t be using them with right now and now I want to talk about the big one which is energy and exercise performance because this is where ketones really can shine okay when we are exercising generally speaking we’re utilizing carbs okay we’re utilizing glucose or utilizing stored glycogen that’s been broken down into glucose now the only exception is when you’re doing very very long duration low intensity cardio okay that’s when your body utilizes beta oxidation and starts utilizing fats as a source of fuel almost 100% but let’s just forget about that one for a second okay if we’re looking at general exercise the body’s going to burn through carbs and then it’s going to go to ketones so if you give yourself ketones in conjunction with carbs your body’s gonna have ketones already available so it’s gonna burn through those ketones which actually yield more energy so you may be storing that glycogen again but you will find that you perform better with your exercise because those ketones are so efficient additionally when it comes to endurance activities exogenous ketones will help you immensely now despite the fact that body composition could go out the window with this okay let’s just not even think about that exhaustion as ketones will allow you to perform significantly better in endurance activities and studies have proven that time and time again whether or not carbs are in the equation now the real place that beta-hydroxybutyrate shines is if you are already in Keith because you’re giving yourself the fuel that you’re already using you’re already using ketones you’re just giving yourself more of it you basically think of it like this if you’re running on carbs we’re told that you should replenish yourself with a Gatorade you get the carbs that come in from a Gatorade and it gives you this energy in the form of carbs carbs aren’t always good because they can get stored as fat ketones don’t get stored its fat so if you’re a carb metabolizer and you add Gatorade into the mix you’re giving yourself carb energy if you’re a ketone metabolizer because you’re in ketosis and you give yourself ketones you’re giving yourself energy so it works out a lot better because those ketones don’t get stored as fat so the simple math here is that if you’re in ketosis ketones will give you a lot of fuel now if you are looking again just for pure mere performance improvements and you’re not worried about body composition or getting a super lean as possible adding ketones in addition to glucose during a workout can be very very powerful you will find that you have a lot of energy because your body can still use the glucose for very high intensity movements but utilize the ketones for the lower intensity movements a good example being CrossFit CrossFit combines a lot of anaerobic all the lifting with aerobic all the jump-roping in the running okay ordinarily we don’t have readily available fuel sources for both types of activity carbs are used for anaerobic fat’s are used for aerobic we don’t always have them readily available but when we use ketones we do you see we have the carbs that are going to get us through the heavy lifts and we have the ketones that are already there to get us through the cardio it’s like the perfect CrossFit or high-intensity interval training fuel again if you’re just looking to perform really well and aren’t worried about losing body fat and that give and workout so hoping this clears the air about exogenous ketones I’m not saying they’re bad and I’m not saying they’re good they have a practical application depending on what you are doing they are good for body composition if you’re already in ketosis they’re great for performance if you’re not in ketosis okay so as always make sure you keep it locking here my channel if you have any ideas for future videos make sure you hit me in the comments section below and as always I’ll see you in the next video

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Ketosis Science: Do Exogenous Ketones Work? Thomas DeLauer

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Ketosis Science: Do Exogenous Ketones Work? Thomas DeLauer….
Exogenous ketone bodies are just ketone bodies that are ingested through a nutritional supplement (think of ketone bodies produced in the liver as endogenous ketone bodies)
Most supplements use bHB as the source of their ketone bodies. BHB is converted to acetoacetic acid and then some quantity converted to acetone through a acetoacetate decarboxylase waste pathway, the acetone will be excreted. Some of the acetoacetic acid will enter the energy pathway using beta-ketothiolase, which converts acetoacetic acid to two Acetyl-CoA molecules. The Acetyl-CoA is then able to enter the Krebs cycle and generate ATP. Exogenous ketone body supplements provide users with an instant supply of ketones.
Exogenous ketone body supplements provide users with an instant supply of ketones and will raise blood ketones even if you’re not in a state of ketosis before ingestion.
Note: Research is in its early stages and more data is needed to understand the long-term effects of combining high blood ketone levels with high or moderate carbohydrate based diets.

Benefits/When to Use: Overview-
Exogenous ketone supplementation causes blood glucose to decrease significantly, likely due to the acute increase in insulin sensitivity. Also improve oxygen utilization, especially in the central nervous system (CNS) – This effect decreases the likelihood of oxygen reaching potentially toxic levels in the CNS.
Ketone bodies are considered neuroprotective as they reduce the inflammation and hyperexcitability that is normally exhibited as glucose metabolism declines in the brain.
Anti-Inflammatory properties: There is evidence that ketone bodies play a crucial role in reducing inflammation by inhibiting a specific class of proteins called inflammasomes.

Weight Loss/Fat Burning:
Note: Exogenous ketones don’t cause weight loss, but rather help promote a ketogenic state. Taking exogenous ketones will let your body know that it is time to use ketones – When you’re done using the exogenous ketones as fuel, your body will start asking for other places to get ketones from – this would be fat.
*Ketones are believed to regulate appetite by altering levels of the hunger hormones cholecystokinin and ghrelin – also affect the hypothalamus region in the brain and positively impact leptin signals*
One study in rats showed that, under conditions of ketosis, glucose consumption is decreased in the cortex and cerebellum by about 10% per each mM of plasma ketone bodies – body will choose to run on ketones over glucose.

Exercise/Athletic Performance:
When you run out of glycogen, your body can either make more, or start making energy from fat. Both of these processes are dependent on using oxygen for energy. However, when you take exogenous ketones, your body can use that energy immediately with much lower oxygen utilization – Exogenous ketones require less oxygen per mole of carbon to oxidize. Exogenous ketones present a way to elevate ketone levels without having depleted muscle glycogen stores (low muscle glycogen is well known to impair sustained physical performance)

Cognitive Function:
In one study, from the journal of Neurology of Aging, 20 subjects with Alzheimer’s disease or mild cognitive impairments were asked to consume a drink that helped elevate ketone levels in their body.
Found that those with higher ketone levels experienced greater improvements in paragraph recall versus those with lower ketone levels.

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3) Exogenous Ketones: What They Are, Benefits of Use and How They Work – Ketosource. (2017, November 21). Retrieved from
4) Yeh YY and Sheehan PM. (n.d.). Preferential utilization of ketone bodies in the brain and lung of newborn rats. – PubMed – NCBI. Retrieved from
6) Ketosis, ketogenic diet and food intake control: a complex relationship. (n.d.). Retrieved from /

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