Keto Fights to Prevent Alzheimer’s & Dementia: Emerging Research- Thomas DeLauer

Keto Fights to Prevent Alzheimer’s & Dementia: Emerging Research- Thomas DeLauer

Keto Fights to Prevent Alzheimer’s & Dementia: Emerging Research- Thomas DeLauer

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your brain can burn to different fuel sources it can burn glucose which it does most of the time and it can burn ketones as a fuel source now one is not necessarily better than the other when it comes down to what your brain needs because your brain always needs glucose but there are some reasons to believe that utilizing ketones as a fuel source it could help lower the risk of Alzheimer’s and dementia but also help improve cognitive function for those that do already have neurodegenerative diseases this is gonna be a science a video so hold on to your hats cuz here we go hey if you haven’t already make sure you hit that subscribe button that way you can get new videos every Tuesday every Friday and every Sunday at 7 a.m. Pacific Standard Time and also turn on that little bell so you can get notifications whenever I do live broadcasts to answer your questions so first off let’s talk about what happens to the brain on a ketogenic diet or at least when you’re fasting and using ketones for fuel because believe it or not when you are fasting the byproduct is ketones and that provides an energy source for your brain in fact that was the original foundation of ketosis in the first place was utilizing fasting to create ketones to prevent and treat epilepsy so what that means is you’re able to reduce the actual impact on the brain we’re not having as much glucose hitting the brain so the brain isn’t as stimulated but it still gets energy in a very effective way now if we can utilize that same kind of thought process and apply it towards Alzheimer’s and dementia and neurodegenerative diseases we can put ourselves in a pretty cool spot for helping out those that are dealing with these kind of diseases now when we look at Alzheimers and dementia in the first place usually it’s an impairment of the brain’s ability to utilize glucose in the first place so what ends up happening is because the brain can’t use glucose as much the brain cells start to shrivel up and die they’re basically starving so if we can condition the brain to utilize fat to ketones as a fuel source a little bit better we’re not gonna fall victim to that glucose starvation in the first place but let’s talk about three things that make the brain a little bit more effective on a ketogenic diet and why it may help out with preventing Alzheimer’s and dementia the first off is mitochondria okay we have mitochondria in every cell within our body that’s how we create energy it’s how we create adenosine triphosphate but we also have this ATP machine is mitochondria in our brains and the cool thing is is beta-hydroxybutyrate which is the main ketone body provides a lot of energy in fact it allows more energy per unit of oxygen than glucose does and this beta-hydroxybutyrate this ketone is utilized and turned into energy in the mitochondria so since we have mitochondria in the brain and since we have beta-hydroxybutyrate when we’re on ketosis then we create more energy without negative byproducts therefore a cleaner burning natural gas burning machine unlike a nasty diesel engine blowing smoke everywhere okay that leads me into the next thing which is the ketogenic diets effect on reactive oxygen species reactive oxygen species is a natural process okay any kind of metabolism is going to have a byproduct of oxygen this byproduct of a reactive oxygen it floats around throughout the brain and it causes all kinds of chaos it reacts with things that’s why it’s called reactive oxygen species now here’s the cool thing if we can control that we can reduce the risk of brain cells dying and shriveling up and going away and ultimately leading to neurodegenerative diseases now the ketogenic diet has been proven to reduce reactive oxygen species because it allows the brain to burn energy in a cleaner way thereby not having this toxic oxygen that flows around and kills the brain cells leading to Alzheimer’s and dementia but that leads me into even the next thing GABA and glutamate okay so gaba stands for gamma amino butyric acid and glutamate stands for well glutamate the glutamate system of the brain is what causes us to feel anxious and have energy it’s an exit or II thing and our bodies and brains are always trying to find this balance of GABA and glutamate and ideally we should be skewed slightly towards the GABA route so we’re a little bit more relaxed but some people are skewed more towards the glutamate route but now neuroscience is starting to show that we can dictate a little bit more within our own control what scale were on you see if we’re in the glutamate cycle we’re using a lot more energy and we’re cramming this energy into the brain just naturally even if you don’t feel it this wears out your brain cells it wears out the neurons it wears out the communication and makes it so your brain fatigues faster because you’re borrowing from tomorrow for today this means you an ultimate end up with a neurodegenerative disease much easier now if your skewed towards the gaba side of things you’re a little bit more relaxed okay you’re not barring from tomorrow for today your brain is on a nice even pace yet still producing energy just as effectively just not going totally haywire at the same time now there’s a study that was published in a journal called trends of neuroscience and they found that literally the presence of ketones made it so that the brain could not load up on glutamate what does this mean it means that when ketones are present the brain cells weren’t accepting glutamate so they were unable to get that super excited excited over-the-top feeling that they would have with Hoonah main therefore making it lean slightly to the GABA scale where we should be calm cool collected relaxed it with a nice steady flow of energy that is clean clear crisp just like Visine right but now there’s a study that was published in 2018 that really makes some sense of this stuff and it’s specifically related to those that already have Alzheimer’s and dementia now this study was published in the journal Alzheimer’s and dementia translational research and Clinical Investigation okay what it did is it took a look at 15 participants ok these 15 participants had mild to moderate Alzheimer’s already and what they did is they put them on a ketogenic diet for a few months and they measured their cognitive skills with a test at the beginning at 3 months and at 4 months now I will say full disclaimer at the end of the four months there were only 10 participants left five of them had to drop out for medical reasons that were not associated with the ketogenic diet but we’re more so associated with their caregivers assessments so anyway with 10 participants that finish this study 9 out of 10 of them had massive improvement in their cognitive awareness and their cognitive skills as deemed by a very reputable test known as the a das cog test this a das cog test measures over 70 different skills so it takes a look at your spatial awareness it takes a look at memory it takes a look at your tasks attentiveness your ability to complete a task a multitude of other things and they found that those that were on the ketogenic diet for three to four months had a five-point increase on this test which is a significant increase now here’s where it gets crazy when they stopped the ketogenic diet their test scores went back to where they were before showing that while they were on the ketogenic diet they were able to activate the portion of their brain and activate the brain cells they weren’t able to activate before to improve their memory and ultimately overcome some of the hurdles that are associated with these neurodegenerative diseases now this isn’t the end-all be-all this doesn’t prove that the ketogenic diet is healing or curing Alzheimer’s and dementia but it means that we’re finding alternative energy sources that don’t utilize the same pathway that leads to the detriment and the ultimate deterioration of our precious brain cells in the first place so as always if you like the science if you want more videos like this put it down in the comment section below I love this neuroscience stuff and I love talking about the brain so as always keep it locked in here my videos and I’ll see you in the next

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Keto Fights to Prevent Alzheimer’s & Dementia: Emerging Research- Thomas DeLauer

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Keto Fights to Prevent Alzheimer’s & Dementia: Emerging Research- Thomas DeLauer… Your brain can burn two different fuel sources. It can burn glucose, which it does most of the time. It can burn key tones as a fuel source. Now, one is not necessarily better than the other when it comes down to what your brain needs. Your brain always needs glucose.

There are some reasons to believe that utilizing key tones as a fuel source, could help to lower the risk of Alzheimer’s and Dementia, but also help improve cognitive function for those that do already have neurodegenerative diseases. This is going to be a science-based video. Hold onto your hats, because here we go.

First off, let’s talk about what happens to the brain on a ketogenic diet, or at least when you’re fasting and using key tones for fuel. Believe it or not, when you are fasting, the byproduct is key tones. That provides an energy source for your brain. In fact that was the original foundation of ketosis in the first place, was utilizing fasting to create key tones to prevent and treat epilepsy.

What that means is, you’re able to reduce the actual impact on the brain and we’re not having as much glucose hitting the brain. The brain isn’t as stimulated, but it still gets energy in a very effective way. Now, if we can utilize that same kind of thought process and apply it towards Alzheimer’s and Dementia, and neurodegenerative diseases, we can put ourselves in a pretty cool spot, for helping out those that are dealing with those kinds of diseases.

Now, when we look at Alzheimer’s and Dementia in the first place, usually it’s an impairment of the brain’s ability to utilize glucose in the first place. What ends up happening is because the brain can’t use glucose as much, the brain cells start to shrivel up and die. They’re basically starving. If we can condition the brain to utilize fat, see key tones, as a fuel source a little bit better, we’re not going to fall victim to that glucose starvation in the first place. Let’s talk about three things that make the brain a little bit more effective on a ketogenic diet and why it may help out with preventing Alzheimer’s and Dementia.

The first off, is mitochondria. Okay, we have mitochondria in every cell within our body. That’s how we create energy and how we create Adenosine triphosphate. We also have this ATP machine, this mitochondria in our brains. The cool thing is, is Beta-hydroxybutyrate, which is the main ketone body, provides a lot of energy. In fact, it allows more energy per unit of oxygen, than glucose does.

This Beta-hydroxybutyrate, this ketone is utilized and turned into energy in the mitochondria. Since we have mitochondria in the brain and since we have Beta-hydroxybutyrate, when we’re on ketosis, then we create more energy without negative byproducts. Much like a cleaner burning natural gas burning machine, unlike a diesel engine blowing smoke everywhere.

Okay, that leads me into the next thing, which is the ketogenic diet’s effect on reactive oxygen species. Reactive oxygen species is a natural process. Okay. Any kind of metabolism is going to have a byproduct of oxygen.

References:
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2) 6 Ways A Ketogenic Diet Improves Brain Function – DrJockers.com. (2017, September 19). Retrieved from

3) Your Brain on Ketones. (2011, April 18). Retrieved from

4) Noh HS , et al. (n.d.). A cDNA microarray analysis of gene expression profiles in rat hippocampus following a ketogenic diet. – PubMed – NCBI. Retrieved from

5) Lutas A and Yellen G. (n.d.). The ketogenic diet: metabolic influences on brain excitability and epilepsy. – PubMed – NCBI. Retrieved from

6) Henderson ST , et al. (n.d.). Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial. – PubMed – NCBI. Retrieved from

7) Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s disease. (n.d.). Retrieved from 7

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