Inflammation Explained: Inflammatory Response with Dr. Landon Pryor

Inflammation Explained: Inflammatory Response with Dr. Landon Pryor

Inflammation Explained: Inflammatory Response with Dr. Landon Pryor

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inflamation I’m always talking about it I’m always referencing it in videos I’m always talking about interleukin 1 interleukin 3 c-reactive protein I’m always talking about tumor necrosis factor I’m always talking about an intrinsic factor I’m talking about all these crazy terms and a lot of times I know you guys you’re probably just listening and it’s going in one ear and out the other so today with me I have my good friend dr. Landon Pryor who is a plastic surgeon you might be thinking where does a plastic surgeon come in with inflammation well I’ve always talked about that connection between bumping your knee or bumping your elbow and how that’s inflammation well no better person to explain what’s happening in the world of inflammation on the surface of your body then someone that quite frankly cuts people open for a living well thank you for that introduction and that’s that’s true that is that is what I do you’re the Guru on inflammation and I think we even went to Starbucks one day and the guy behind the counter was like you’re the inflammation guy that’s what you want to be known as but inflammation contrary to what popular Thomas typically talks about is not always a bad thing you need inflammation that’s how you heal from bumping your knee that’s how you heal from surgical injury or any kind of trauma inflammation is bad when it gets out of control and your body’s causing systemic issues for no real medical necessity so all the things that you talk about that cause inflammation are making you feel sick and not promoting healing they’re just causing damage in your body and you know for instance when Landon’s wrapping up a surgery and and you’re going through the healing process everything that is involved in actually healing that wound truly is inflammation at its very best and you think about that that’s that takes a lot of immune system energy right I mean that’s you know I mean inflammation like like the name implies is the inflammatory cells in the immune system going to an area of injury to heal it so without inflammation you can’t heal and surgery is a is a very specific type of injury to the body and you need those inflammatory cells to be able to heal but when it goes unchecked it can become pathologic and essentially when you think about that you think about you that’s occurring at the site of an injury or at the site of surgery the same inflammatory cytokines the same interleukins the same actual macrophages white blood cells everything that’s going to heal that area that same thing applies at the cellular level and we hear this term chronic inflammation all the time we hear people talk about inflammation and I quite frankly feel like it’s this ambiguous term that 95% of the population just hear and just know it’s bad but they don’t ever really register what’s going on in the body and and generally speaking I go extremely in-depth and scientific but I wanted to take this video to really just articulate it in a very simple way so that you can share with your friends and family and understand what’s happening at the cellular level so you mentioned I mean what kind of immune response so you don’t have to go into detail but I mean healing from a wound like a surgery that’s pretty taxing on the immune system in general right it takes a lot of energy from the body of course and that’s why people are tired when they’re recovering from surgery it’s a huge metabolic demand on the body to recover and to go through that recovery process okay so let’s take that as an example okay now think about the amount of macrophages which are white blood cells okay macrophages is a fancy way of saying we’re also known as they’re called big eater cells okay the reason they’re called big eater cells is because they go around and they eat up bacteria they go around and they eat up different parts of cellular waste and everything like that so they’re called big eater cells so when I say macrophages that’s what I mean these macrophages are really just isolated at that source well we don’t always realize is that those macrophages are triggered in different responses in the body too and when we talk about cellular inflammation we’re talking about the same kind of trauma that’s happening on the surface of the skin and through the connective tissue through the muscle that’s actually happening to a cell now it’s not necessarily getting cut open but it’s becoming so damaged that the same inflammation that has to heal that wound is having to heal your cells or having to process waste yeah if you think about it like he’s saying you’re having these mini surgeries all over your body if you have chronic inflammation your body is having to fight that chronically and recover from it and it’s a huge energy drain on your body and people think inflammation is always just being puffy or being inflamed MA that’s more swelling which is a byproduct of inflammation and the inflammatory cytokines that are introduced into into the area of injury but inflammation is not synonymous with edema or swelling inflammation is the primary cause that then causes people to be swelling input to be swollen and puffy gotcha yeah exactly and when your body is stressed out and your immune system is taxed here’s an example to know if you’ve ever gotten a cold or the flu or you’ve been really sick have you ever noticed that sometimes even if you’re dehydrated your rings don’t fit real well things get puffy well it’s because it is a natural response a secondary response to inflammation to retain water and it’s your body’s protective mechanism if you are fully hydrated and so for example you have a patient that goes through a major surgery and they’re healing if they’re dehydrated the skin is going to retract and it’s not going to take a lot more energy to heal so when you’re hydrated of course it makes things better so inflammation is going to encourage the hyper hydration of a specific area which sometimes leads to basically that swelling and that over inflammation in terms of the actual water volume at a localized source yeah me personally at this point now that I’ve been doing pretty much low carb or no carb for about a year if I have a carbohydrate heavy meal I notice right away that my hands are puffy in full and I don’t know if you get the same kind of response and I just don’t feel well and that’s that’s inflammation happening because of the amount of carbohydrates that I that I’m consuming and you know my body just doesn’t know what to do with it anymore exactly it becomes a waste product it really becomes in it part of it is the fact that your body is becoming somewhat inefficient at metabolizing carbohydrates which at first sounds bad you know it’s like your body’s well I don’t want to be any efficient at utilizing carbohydrates I want to be efficient at everything but the fact is is that you know when you start getting your body to utilize a different fuel source that’s going to come a little bit cumbersome for your body so therefore you know your response your immune response or interleukin response you know the big one is nuclear factor Kappa B which is like the main epicentre for inflammation and that becomes tremendously elevated with any kind of sugar or you know any kind of any kind of carbohydrate really that’s relatively high glycemic now when we kind of again relate that to cellular inflammation and the fatigue and everything like a good example for my audience for people watching this video is going to be the trauma associated with working out and this is exactly where I think you come in perfectly because when you’re when you’re cutting someone open or you’re doing surgery I mean you’re causing essentially a major trauma but at the cellular level you know a series of micro trauma might excuse me micro trauma and the sarcoplasmic reticulum with like the muscle cells is it safe to say that that same thing at a smaller scale is happening when you’re going to the gym and you’re tearing muscle of course I mean that’s not like I said inflammation isn’t a bad thing when when being utilized appropriately that’s what’s happening when you’re when you’re working out like you said you’re creating these micro traumas and your body has to heal from that just like it does from any kind of injury whether it’s working out or surgery but that’s exactly what’s happening when you’re working out and you know in that example it’s it’s it’s helpful obviously because your body is gonna recover and actually improve because of it exactly and it’s something I’m always talking about is that you know overtraining is a serious thing for that reason you know inflammation is good to an extent like dr. Pryor said but when you start overtraining and you train to this extreme you get to this point where you have such chronic levels yeah exactly and it’s it’s not just gonna make it so you can’t recover and get it into the gym as much as you want but it’s gonna make it so that your body’s immune system is absolutely taxed which you may be thinking I can deal with getting sick now and then but no your immune system being taxed is halting your fat loss goals it is halting your muscle building goals it is halting your cognitive function it’s slowing a lot of things down and if you don’t like we talked about previously if you don’t if you have inflammation going on and you don’t feel good you’re not going to be motivated to eat a healthy lifestyle and to go to the gym and make good choices so you know really that that’s the initial issue is to minimize the amount of unnecessary inflammation in your body so that you do have the energy to make better choices and lead a healthier lifestyle and so dr. Pryor is opening up a practice out here in the LA area and so he’s gonna be doing a lot more videos with me he’s going to be coming on the show a lot more talking about things from his perspective and I definitely want to hear in the comments section videos that you’d like to see in the future videos that I can do with dr. Pryor that address a little bit more of the surgical side of things the medical side of things but also just videos that you’re interested in seeing in general I always love seeing your comments and what you want to see so dr. Bryar appreciate you being here and look forward to doing a lot more see you guys soon

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Inflammation Explained: Inflammatory Response with Dr. Landon Pryor

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What is Inflammation? How Does Inflammation Work? What Does Inflammation Do?
Inflammation: I’m always talking about it, I’m always referencing it in videos, I’m always talking about interleukin-1, interleukin-3, C-reactive protein. I’m always talking about tumor necrosis factor, I’m always talking about intrinsic factor. I’m talking about all these crazy terms. A lot of times, I know you guys are probably just listening and it’s going in one ear and out the other. Today with me, I have my good friend Dr. Landon Pryor, who is a plastic surgeon. You might be thinking, “Where does a plastic surgeon come in with inflammation?” Well, I’ve always talked about that connection between bumping your knee or bumping your elbow and how that’s inflammation. Well, no better person to explain what’s happening in the world of inflammation on the surface of your body than someone that, quite frankly, cuts people open for a living.

Well, thank you for that introduction. That’s true, that is what I do. You’re the guru on inflammation. I think we even went to Starbucks one day and the guy behind the counter was like, “You’re the inflammation guy.”

I am kind of inflamed. I’m not sure that’s what you want to be known as, but inflammation, contrary to what Thomas typically talks about, is not always a bad thing. You need inflammation. That’s how you heal from bumping your knee, that’s how you heal from a surgical injury or any kind of trauma. Inflammation’s bad when it gets out of control and your body’s causing systemic issues for no real medical necessity. All the things that you talk about that cause inflammation are making you feel sick and not promoting healing, they’re just causing damage in your body.

For instance, when Landon’s wrapping up a surgery and you’re going through the healing process, everything that is involved in actually healing that wound truly is inflammation at its very best. You think about that, is that it takes a lot of immune system energy, right? I mean, that’s [crosstalk 00:01:46]-

Yeah, I mean, inflammation, like the name implies, is the inflammatory cells in the immune system going to an area of injury to heal it. Without inflammation, you can’t heal. Surgery is a very specific type of injury to the body, and you need those inflammatory cells to be able to heal. When it goes unchecked, it can become pathologic.

Essentially, when you think about that, you think about the inflammation that’s occurring at the site of an injury or at the site of surgery, the same inflammatory cytokines, the same interleukins, the same actual macrophages, white blood cells, everything that’s going to heal that area, that same thing applies at the cellular level. We hear this term, “Chronic inflammation,” all the time. We hear people talk about inflammation. I, quite frankly, feel like it’s this ambiguous term that 95% of the population just hear and just know it is bad, but they don’t ever really register what’s going on in the body.

Generally speaking, I go extremely in depth and scientific, but I wanted to take this video to really just articulate it in a very simple way so that you can share it with your friends and family and understand what’s happening at the cellular level. I mean, what kind of immune response, and you don’t have to go into detail, but I mean, healing from a wound like a surgery, that’s pretty taxing on the immune system in general, right? It takes a lot of energy from the body?

Of course, that’s why people are tired when they’re recovering from surgery. It’s a huge metabolic demand on the body to recover and to go through that recovery process.

Okay, so let’s take that as an example. Now think about the amount of macrophages, which are white blood cells. Macrophages is a fancy way of saying … also known as … they’re called big eater cells. The reason they’re called big eater cells is because they go around and they eat up bacteria, they go around and they eat up different parts of cellular waste and everything like that. They’re called big eater cells, so when I say macrophages, that’s what I mean. These macrophages are really just isolated at that source. What we don’t always realize is that those macrophages are triggered in different responses in the body too. When we talk about cellular inflammation, we’re talking about the same kind of trauma that’s happening on the surface of the skin and through the connective tissue and through the muscle. That’s actually happening to a cell. Now, it’s not necessarily getting cut open, but it’s becoming so damaged that the same inflammation that has to heal that wound, is tasked with having to heal your cells or having to process waste.

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