How to Use GKI to Enhance the Keto Diet

How to Use GKI to Enhance the Keto Diet

How to Use GKI to Enhance the Keto Diet

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thanks to science and some pretty simple formulas we can actually start to determine where we are going to get the best metabolic result with our fasting with our food intake and even with our exercise and I don’t just mean simple stuff I mean like truly being able to determine what our optimal metabolic zone is like where I particularly would burn fat might not be the same as where someone else would burn fat or where you would burn fat and by measuring what is called the glucose ketone index we can really start to uncover our own bio individuality and what works for us when it comes from optimal results overall with brain energy and with fat loss you are tuned into the Internet’s and leading performance nutrition and fat loss channel new videos every single Tuesday Friday and Sunday at 7 a.m. Pacific time and a bunch of other videos throughout the week as well so you’re never missing a beat I need to ask you to hit that little bell button and it’s gonna allow you to turn on notifications that way you know whenever I post the video so the algorithm doesn’t make it so you don’t see the content but it’s also gonna let you know whenever I go live which is something you don’t want to miss all right so let’s go ahead and dive in so what I want to talk about is something known as the glucose ketone index and it sounds super complicated but it’s actually like one of the easiest things to calculate and at the end of this video I’ll explain how you calculate it but I promise you can do it it’s easy the g ki is simply your ratio of blood glucose to ketones and what it does is it gives you sort of a single value for overall what your metabolism is like in terms of how much fat are you using how much ketones are you truly using is it really effective for you you see it tracks your metabolic zone this is really really important you see for example if we were to test our ketones or test our glucose it’s gonna change consistently like I could test my ketones right now and I show a 1.5 and show that I’m in ketosis then I could test it three minutes later and it might show a 0.7 and sometimes people get concerned they’re like my readings are all over the place well the fact is our bodies are very dynamic and things are changing all the time so like for example if we go and exercise when we exercise our blood glucose is gonna go up it’s a totally normal thing which means that our ketones could go down so we have all kinds of things that come into play if we get stressed out for instance our glucose is going to go up so what we want to look at is the Oh all ratio between the glucose and the ketones because it’s that Delta between the two that truly tells us overall what our ketone level is like and what our metabolic health is like this isn’t apples to apples but it’s almost like looking at your a1c which is your long-term glucose value like your if you’re diabetic you measure your a1c this is the closest we can get to that with ketones now gki was developed by dr. Thomas Seyfried and it was basically for brain tumor management you see well what he knew was that brain tumors were very glycolytic meaning brain tumors really liked carbs okay they’re a fermentable fuel source for specific astrocytomas and all kinds of things so that simply means that when we consume carbohydrates we have high levels of blood glucose it could potentially be fueling specific kinds of brain tumors now I promise this video isn’t necessarily about cancer about brain tumors but we end up be using the science that comes from that brain tumor world and from the cancer community to understand how we can optimize our lives overall so what he found was that this gki was a great way of determining the overall fermentable fuel and the non fermentable fuel glucose vs ketones without just having to take an instant snapshot like every five seconds to get that result so he’s the one that gave it the term metabolic management because he was looking at it from the side of this is metabolic management for cancer patients which brings me into the first study this first study was published in the Journal of the American College of nutrition took a look at two pediatric patients now before you discount this study because there’s only two patients let me help you understand that when you’re doing cancer studies a lot of times is difficult to just group them all together there’s different kinds of cancers so in this particular case it took one pediatric patient that had a cerebral er astrocytoma and another one that had anaplastic astrocytoma two different kinds of brain tumors but the grand scheme of things fairly similar okay so what they had them do is go on a ketogenic diet for eight weeks so what they found is at the end of eight weeks they took their glucose ketone index rating from 27.5 all the way down to 0.7 to 1.1 now let me make something very clear you want to have a low G ki a low G K I means you have lower glucose and higher ketones so again when we look at the overall aggregate and the overall average it’s a nice way to be able to say okay here’s where I want to be my overall Delta between glucose and ketones is nice and low meaning for the most part over the long haul I’m predominantly utilizing ketones they also found within this study that the patient that had the anaplastic astrocytoma ended up having over a 21% reduction in deoxy glucose uptake of the actual tumor so what that means is the deoxy glucose didn’t get into the tumor wasn’t feeding the tumor so therefore the tumor was essentially starving because this tumor wasn’t able to run on ketones then we looked at the cerebellar tumor there is a 21 point 8 percent reduction in that flora deoxy glucose uptake as well so a huge just reduction overall in both kinds of cancers when it came down to the fuel that actually feeds those cancers which leads me into another study when we actually look at tumor size and again bear with me because this is all going to make sense we just look at it from the cancer community because it’s clear concrete evidence this next study was published in the journal nutrition and metabolism took a look at a 65 year old female with a Geo blastoma multiform another kind of brain tumor that can be pretty aggressive very volatile type of tumor so what they found is when this patient went on a strict eight-week ketogenic diet with a mild calorie deficit she had a pretty significant reduction or gki 37.5 all the way down to 1.4 huge reduction okay well here’s what’s really cool they found and of course this patient was also doing chemotherapy but they found that when she brought her gki down low for eight weeks the tumor disappeared there was no detectable tumor when the gki was nice and low meaning that those ketones were chronically high in a good way starving the tumor 10 weeks after going back on carbohydrates and off the keto protocol the tumor reappeared showing that yes these tumors definitely feed on glucose but overall it’s not just the independent spikes of glucose and ketones it’s the overall level and gki is how we measure that so now you’re wondering okay I don’t have a brain tumor so how is this going to benefit me it’s going to benefit you greatly because here’s why that gki gives you a clearer picture where you are at a given point in time over the longer haul for example if you wanted to measure your ketones and your glucose during a workout you could actually get a broader idea of where you really are rather than just testing your ketones or just your glucose let me give you a clear example ok I go into the gym when I start working out my glucose level goes up but as I start to go through my workout and I’m in the gym for a longer period of time my glucose levels start to stabilize and my ketone levels start to come up so by measuring my glucose and my ketone levels then and there I can calculate my gki which tells me if I’m actually burning fat let me give you another example if you have two different people one person will call them person a likes to do a lot of cardio and the other person person B likes to do a lot of weight training if they both go into their workout and they’re both doing the same diet they’re gonna have different G K is because person a might end up having a different level of glucose and a different level of ketones then person B so it’s a way for them to determine the bio individuality determine wait a minute when I’m doing weight training I seem to have a better G ki and then the other person might say well I have a better ji ki when I’m doing cardio it allows us to get out of this in one size fits all approach and truly understand where our ideal metabolic zone is if our G ki is lower we know that we’re using more fat so this is phenomenal if you’re trying to burn fat to know what your G ki is it’s really really cool stuff and again when it comes down to fasting it’s the same kind of thing normally when we fast our body likes to use fat as a fuel source but another thing can happen when you fast your blood glucose levels can rise simply because your body kind of panics it goes into stress so glucose levels go up well once you get adjusted to a fast those glucose levels start to come down so it allows us to know when we start getting optimized during a fast so if I’m gonna go fast for it let’s again hypothetically say 24 hours I might find that my G ki doesn’t really drop to where I want it until like 18 hours which means I should probably push my fast a little bit longer so I actually get the benefit because my G ki is staying high all the way up to 18 hours then I’m really not getting a whole lot of benefit at least in terms of fat loss except from a calorie deprivation standpoint so it’s pretty fascinating stuff now of course you guys know that I’m a big fan of the keto mojo meter because it’s one of the only meters that can actually measure your glucose and your ketones so you want to use something like this you want to be using a keto mojo meter so that you can actually go to the gym test your ketones and test your glucose and then do a really simple calculation and I’ll explain how that calculation works but for those of you that are watching there is a special discount that you’re not going to find anywhere else down in the description below for the keto mojo meter honestly if you’re looking to take fasting to the next level keto to the next level and you’re really trying to get the most fat loss out of everything you have to be using this you can’t just use guesswork if you’re trying to just feel good and maybe lose a little bit of weight sure you can get by without a meter but if you’re really trying to determine what your gki is and you’re really trying to determine what the best kind of workouts you can do are or what the best period of fasting is for you you have to measure and honestly these things are super affordable the ketone strips are super affordable way more affordable than any other meter and honestly I’m on their advisory board because I like what they do with science so go ahead and click on the link and take advantage of it and get your hands on one okay now it also can help you when it comes down your relationship with food people sometimes get concerned like okay when I eat this chicken breast it kicks me out of keto well does it really because we have to look at the big picture if you eat that chicken breast with some coconut oil there’s a good chance that your glucose might go up what your ketones might go up even more which means who knows your gki might even be better you might have a better overall level of ketones in your body by looking at the ratio between your glucose to ketones so it’s very very very important because if I eat that chicken breast and my glucose goes up I might be like oh no it’s kicking me out of quito but it’s not the case if it’s simultaneously making my ketones higher see what I’m saying so this is very very important now how do you actually measure it well this is the cool thing super super easy and I’m sorry that I’ve strung out throughout the entire video but it makes sense just to explain things first all you have to do is measure your blood glucose then you divide that number by 18 and then you divide that number by your overall ketones and that’s it that’s your G ki that’s you want to have it nice and low okay anything below one is considered therapeutic ketosis like deep deep deep ketosis and I don’t expect you to be there okay but you really want to be in the range I like to say one two three that’s a really good number if your glucose ketone index is above a nine you’re not in ketosis at all okay so you want to make sure that you’re keeping below a nine no matter what I mean you might pop in and out here and there but really you want to be in that like one to five range it’s like a nice ideal range to be now the only reason that we divide by 18 fYI is simply because at least in the Western world we’re looking at glucose as a milligrams per deciliter so all we’re doing we divide that by 18 is we’re making equivalent to the metric system which is going to be measuring millimoles per liter if you are already using millimoles per liter all you literally have to do is divide your glucose by our ketones the only reason we divide by 18 in the Western world is to get that milligram per deciliter number to a millimole per liter number which may sound complex but that’s all there is do so anyhow I hope that this helps clear some things up you should start determining where you are just for me where you’re actually burning fat so you can get the most out of things and please please please take advantage of the key no mojo meter that you can get a special discount on down to the description below see you soon

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How to Use GKI to Enhance the Keto Diet

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How to Use GKI to Enhance the Keto Diet

The GKI, or the Glucose Ketone Index, is a formula that tracks the ratio of blood glucose to ketones as a single value – it’s a biomarker for tracking your metabolic health as well as your level of ketosis

Use in Studies

Developed by Dr. Thomas Seyfried for management of brain cancer

Was created to track the zone of metabolic management for brain tumor management – a biomarker that refers to the molar ratio of circulating glucose over bHB

Brain tumor cells are dependent on glucose for survival and cannot effectively use ketone bodies as an alternative fuel, a zone of metabolic management can be achieved under conditions of low glucose and elevated ketones

Ketone bodies also prevent neurological symptoms associated with hypoglycemia, such as neuroglycopenia, which allows blood glucose levels to be lowered even further

Hence, ketone body metabolism can protect normal brain cells under conditions that target tumor cells

The zone of metabolic management is considered the therapeutic state that places maximal metabolic stress on tumor cells while protecting the health and vitality of normal cells

Dr. Seyfried noticed in his studies that the therapeutic benefits of keto increased with the lower the glucose ketone index ratio gets – a GKI of lower than 1.0 is prime therapy for patients with cancer

Study #1 – Journal of the American College of Nutrition

The first study evaluated two pediatric patients; one with an anaplastic astrocytoma, and another with a cerebellar astrocytoma – both individuals were placed on a keto diet for 8 weeks

During the 8-week treatment period, GKI dropped from about 27.5 to about 0.7 – 1.1 in the patients

The patient with the anaplastic astrocytoma, who did not have a response to prior chemotherapy, had a 21.7% reduction in fluorodeoxyglucose uptake at the tumor site (no chemotherapy during diet)

The patient with the cerebellar astrocytoma received standard chemotherapy concomitant with the ketogenic diet

Fluorodeoxyglucose uptake at the tumor site in this patient was reduced by 21.8% – quality of life was markedly improved in both children after initiation of the KD

The patient’s GKI decreased from 37.5 to 1.4 in the first three weeks of the diet. No discernible brain tumor tissue was detected with MRI in the patient at the end of eight weeks of the calorie restricted ketogenic diet

It is also important to mention that the patient was free of symptoms while she adhered to the KD – tumor recurrence occurred 10 weeks after suspension of the ketogenic diet

**The glucose ketone index isn’t just for cancer treatment. This value is also of importance for people who have blood sugar issues. The GKI also isn’t just for ketosis.**

On Exercise: It is healthy for blood sugar to rise during exercise because the muscles need the excess fuel to compensate for the increased demand placed upon them. But in most people the body will adjust after exercising and bring the blood sugar levels back to normal

On Fasting: Tracking the glucose ketone index can be a very helpful piece of biofeedback to understand how your metabolism is responding during the fasting period. Over time, you can look back at different fasting periods and use the index as an indicator of your metabolic state during the course of the fasting period

With Food: **Blood glucose and ketone values should be measured 2–3 hours postprandial, twice a day if possible – allows individuals to connect their dietary intake to changes in their GKI**

(Your Glucose Level / 18) / Your Ketones Level = Your Glucose Ketone Index

You divide the glucose number by 18 because glucose readings in the U.S. are measured in mg/dL, and dividing by 18 converts that number to mmol/L to match your ketones reading


1) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. (n.d.). Retrieved from
2) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. (n.d.). Retrieved from
3) Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. (2013, September 4). Retrieved from
4) Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. (n.d.). Retrieved from 3

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