Glutathione Detox: The Science of Glutathione and Alcohol – Thomas DeLauer

Glutathione Detox: The Science of Glutathione and Alcohol – Thomas DeLauer

Glutathione Detox: The Science of Glutathione and Alcohol – Thomas DeLauer

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glutathione the brain aid the liver aid all combating the horrible effects of that horrible thing we know of called oxygen right okay so what’s crazy here is oxygen is not always an amazing thing within the body obviously it’s necessary but there are some byproducts when it comes down to oxygen metabolism when it comes down to that aerobic metabolism I want to talk about something called glutathione in this video you see we hear about glutathione all the time we hear kind of surface level stuff about how it might be able to help the brain how it might be able to help the liver and we hear a lot of kind of the neuro gurus talking about how it could be a potential nootropic and help brain activity well they’re kind of right but I want to explain a metabolic process and how glutathione actually works in the body and how you can naturally increase your levels of glutathione so your body can find that homeostasis that it needs to perform at its best so here’s the thing glutathione is actually a peptide it’s a peptide of three different amino acids so it’s glutamic acid its cysteine and it’s glycine those three amino acids combined create a peptide that’s also known as G SH or in this case glutathione now glutathione has a lot of different functions within the body but it’s mainly geared towards oxygen metabolism you see we have aerobic cells in the body those aerobic cells combine oxygen with other components of the body to create energy well whenever they create energy they have a certain level of cellular waste aerobic waste oxygen waste specifically in this case something called the reactive oxygen species or ro s in this video I’m going to refer to glutathione as G SH and refer to the reactive oxygen species as ro s now that ro s sounds like a horrible thing because it’s a byproduct or it’s cell waste however it’s also important because if we don’t have that level of RO s our body never knows how to regulate cell metabolism it never knows how to regulate energy when it comes to aerobic metabolism so although it’s not necessarily a bad thing when it is in excess it can become bad and that’s where glutathione comes in so this G SH plays a big role and actually mitigating the excess oxygen or the reactive oxygen species that occurs when we have aerobic metabolism so it’s basically a hardcore antioxidant a hardcore free radical eliminator specifically works with aerobic cells so that we can get the most out of our oxygen and ultimately get the most out of our days in the office in the workplace and also in the gym and at home so the body is all about balance right you know we have these natural negative feedback loops these natural feedback loops that always keep things in homeostasis and I know homeostasis is kind of a term that’s thrown around a lot for people to sound smart sometimes but a lot of times homeostasis is critical all of our hormones have this level of homeostasis where they’re always trying to find balance well whenever you have any kind of cell metabolism as well there’s always this level of homeostasis your body’s finding balance you see if your body goes into a really injured state where the cells are really damaged because you’re overtraining or because you’re super stressed well then your body is going to have a lot more free radicals so consequently to find balance your body’s going to increase some of these natural antioxidants in this case glutathione is one of the most potent ones the body’s going to naturally increase those levels so it can bring the levels back to normal keep you in balance the problem is sometimes our glutathione stores can get depleted and what happens then is then we have oxidative stress that overwhelms the body and can make you feel downright miserable and weak so let’s talk about the benefits of glutathione or gsh let’s talk about specifically what people seek glutathione out for okay let’s talk about one it’s protecting you from a lot of toxins environmental and internal so basically internal toxins being the cell wastes external toxins being alcohol being things outside BPA’s all these different toxins that were exposed to well glutathione can help mitigate those obviously reducing the oxidative stress additionally glutathione is known to reduce peroxide levels so basically peroxide like hydrogen peroxide our natural bleaching agents they’re a byproduct of cell metabolism as well and glutathione can help reduce those now additionally glutathione also helps the metabolism taking some of the stress off the livers that the liver can produce the enzymes and the hormones that it needs to help metabolize food metabolize fat metabolize sugar and ultimately make you feel your best and then of course glutathione is going to help out your immune system because when the body’s not under that kind of stress when the liver is able to do its job and the brain is able to do its job and sing signals appropriately well then your immune system where better your inflammatory responses go down your immunoglobulins a your you know globulin be all those IgA IgG IgM immunoglobulins go down and allows your body to heal plain and simple but for the sake of this video I want to specifically talk about how glutathione works for the brain and works for the liver because those are the most exciting components I think you’re going to get the most benefit out of that ok so the brain the brain makes up 2% of our overall body weight yet it utilizes 20% of our overall oxygen in the entire body so you do the math right there and you can kind of figure it out that the brain is running on a high amount of oxygen per overall weight so what that tells us is there’s going to be a large amount of oxidative stress there’s going to be per-capita a lot more our OS as a result of oxidative metabolism then there would be anywhere else in the body what that means is glutathione is going to be more important in the brain than in any other portion of the body in order for that cell recovery to occur in order for that cell damage to stop for our brain cells to stop dying and for us to be able to actually grow neurologically and in the brain we need those levels of glutathione now glutathione doesn’t just magically appear in the brain like I said earlier in this video it has to be synthesized and generally the gsh that’s synthesized in the brain is synthesized from a specific amino acid called cysteine and that cysteine is triggered by a specific enzyme that’s called a glutamate cysteine lipase enzyme that enzyme reacts with the cysteine to create the gsh that allows the brain to recover now here’s the kicker we have so many different components of our brain doing so many different things that we actually require different precursors for gsh for different components of the brain now for the sake of this video I’m going to stick to cysteine because cysteine seems to be the most common amino that needs to be synthesized in order to produce that gsh so if you consume the right kind of precursors from the right kind of diet or the right kind of amino acid consumption your brain can produce that glutathione it’s actually being shown that your brain responds better with the precursors to glutathione than it does with direct exogenous use of say a glutathione supplement now let’s talk about the liver and specifically how the liver works when it’s metabolizing alcohol and how good I own actually plays a pretty big part in that you see when you take a sip of alcohol when you’re out with your friends and you’re just chilling you take that sip of alcohol as soon as it hits your mouth as soon as it hits your saliva it is converted into something called acetaldehyde now I’ve done videos on acetaldehyde before and I go in more depth you see but not all of that alcohols can bring it into acetaldehyde only most of it so the remainder travels down into your liver where the liver converts the rest into acetaldehyde well newsflash acetaldehyde is probably one of the most toxic things that you can possibly consume so what does the liver do the liver prioritizes the metabolism of that acetaldehyde it stops it in its tracks and it does everything that it can stopping all other metabolic processes to make sure that it can break down this acetaldehyde well how does it do that it uses glutathione or gsh you see that glutathione in a way actually somewhat neutralizes the acetaldehyde it neutralizes it to something that’s about the acidity of vinegar turning something that’s super super toxic into something that’s not all that toxic after all so that shows the importance of glutathione stores in the liver so now if you’re exhausted or if you’re training hard or if you’re super overall just fatigue stressed out well then your glutathione levels are going to be depleted your overall aminos that make up those glutathione stores are going to be depleted which means your liver isn’t going to be able to process that acetaldehyde which means all the other metabolic processes go on a back burner creating enzymes digesting food creating bile all the things that are necessary for survival start going on the back burner why the liver is just churning and churning and working really really hard to produce this glutathione so I wasn’t born yesterday I know that now all of you are probably sitting here watching saying okay well how do i boost my glutathione levels how do i specifically boost my glutathione levels if i’m going out with my friends i want to have a drink okay well right now the evidence is pretty inconclusive there’s not a lot of science supporting the exogenous use of pure glutathione you see since that glutathione response is sort of a negative feedback response based on your body trying to find homeostasis to different situations taking exhaustion as glutathione may not actually impact your overall glutathione stores however what it is being shown is that you take the precursor to glutathione like some of these amino acids particularly cysteine if you take cysteine then your body is able to produce more glutathione you’re better off in giving your body the fuel to actually produce glutathione then you are just taking an exam this supplement now another thing that you can do is take milk thistle if you take milk thistle then you can take some of the stress off the liver so the liver can produce more glutathione so it can actually fight against the toxins that it needs to fight against so at the end of the day this wasn’t a fix-all for all your problems but I’m going to do more videos that explain how this process works how the liver actually detoxes and how cell metabolism works when it comes to burning fat when it comes to getting the most out of your brain when it comes down to just plain feeling good so as always leave your comments below let me know what kind of videos you want to see specifically pertaining to this topic and specifically pertaining to alcohol consumption and how our bodies work when it comes to detoxifying all the horrible things that we’re constantly doing as all I keep it logged in to my videos and I will see you in the next one

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Glutathione Detox: The Science of Glutathione and Alcohol – Thomas DeLauer

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Glutathione Detox: The Science of Glutathione and Alcohol – Thomas DeLauer…
Your body can have its own glutathione detox! Glutathione and Alcohol is a huge question, how does it actually work? More at
What is Glutathione? Glutathione (GSH) is a peptide made up of three amino acids – glutamic acid, cysteine and glycine. GSH is produced by every cell in our bodies. It is an antioxidant that works within cells. Aerobic cells in our body require oxygen. During the cellular processes that occur, ROS (reactive oxygen species) occur. When cells are injured even more ROS will be produced. ROS are not always bad. They are necessary for cell survival, but when there are too many produced it can lead to cell damage and death. When the levels of ROS raise, our bodies work to balance this out and regain homeostasis through the production of antioxidants, such as GSH.

GSH:
-Protects against oxidative damage and environmental toxins
-Disposes peroxides (natural bleaching agents that cause harm in the body)
-Participates in metabolic processes
-Maintains intracellular health
-Boosts immune system

Due to its properties, GSH:
-Protects brain health
-Protects liver and other organs from damage
-May protect against many other diseases due to cell damage, including Alzheimer’s, cancers and AIDs

It has been found that most patients in the hospitals for conditions such as cancer and AIDs have depleted GSH levels. So what are the ways that we understand presently that GSH benefits our health?

Brain Health: The cells of the brain make up 2% of our body weight while consuming 20% of the oxygen used in the body. The makes brain cells particularly at risk to oxidative damage. GSH is important in the detoxification processes of reactive oxygen species in the brain. Under normal conditions GSH synthesis is determined by cysteine availability and the activity of an enzyme called GCL (glutamate-cysteine ligase). Cysteine comes from the diet, protein breakdown and the liver. The amount of GSH present in the brain is dependent upon how much of the precursors are present. Different kinds of brain cells require different precursors.

Liver: Helps the liver remove chemicals, such as drugs and environmental toxins. Glutathione is produced by the liver in response to alcohol consumption. When alcohol comes into contact with enzymes in your mouth, Acetaldehyde forms. Acetaldehyde is extremely toxic. When the remainder of the alcohol reaches your liver, it is processed into Acetaldehyde and your liver produces glutathione, which attacks the acetaldehyde to form a non-toxic substance similar to vinegar.

Cancer: Oxidative stress can lead to cancer, and GSH can help protect against oxidative stress. This is how GSH can help to protect your body from cancer. There is an instance where medical professionals may desire to reduce the GSH in your cells, and that is when fighting cancer cells with chemotherapy. High GSH levels in tumor cells can make them difficult to fight. There is other evidence that GSH supplementation may help to reduce chemotherapy side effects and thus make it more effective, so this is currently under debate.

How to Get Enough GSH: While studies have shown that elevated GSH levels can benefit health, exactly how to boost these levels is still debated. Supplements have not been proven to be an effective way to boost cellular GSH. Intravenous GSH was shown in one study to boost the survival rates and decrease the side effects from chemotherapy in women with ovarian cancer. It is likely that taking precursor supplements of cysteine may boost GSH levels. A balanced diet is the key to healthy GSH levels – fresh fruits, veggies and meats.

2 supplements that help boost GSH levels are:
-Milk thistle
-Whey protein

References:
1. Metabolism and functions of glutathione in the brain

2. Role of glutathione in cancer progression and chemoresistance

3. Glutathione: new supplement on the block

4. Protective effects of silymarin, a milk thistle…

5. Oral supplementation with whey protein increases plasma glutathione…

6. Glutathione and sulphur amino acids in health and human disease
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