Does ONE Calorie Stop Autophagy and Wreck a Fast?
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hey I need you to stop freaking out about Auto Fuji yeah stop worrying about your fasting regimen stop worrying about your intermittent fasting protocol based upon otology look at Alta Fiji is awesome it’s quite honestly probably one of the most powerful gifts that Nature has given our bodies the ability to recycle old portions of a cell and recycle broken pieces of DNA but it’s not the end-all be-all and it’s not this linear equation for example the longer you fast you don’t necessarily get more auto Fujii that goes with a longer fast we have different rates of autophagy that are occurring at different times within our body within different tissues and I’m gonna help you understand this so that you can relax a little bit and maybe not be quite so stressed out about otology so anyhow what is otology well to make matters very very simple autophagy is your body trying to find homeostasis at the cellular level by turning over specific proteins and turning over different portions of a cell so basically when you are starving or when you’re under stress the body says well we don’t need this portion of a cell because it’s just wasted material right now so let’s go ahead and just recycle it and eat it so basically the cells eat themselves in order to get more energy now this is up regulated and upscaled during times of stress because of course there’s more stress and more impact on the cell but there’s two kinds of auto AG that you need to know about and this gets a little bit complex but we’ll make it really simple and have some fun with it okay there’s macro otology which is the kind of autopsy that we generally hear about macro autophagy is where you have something known as an auto phagosome which is basically like a little spherical let’s think of it like a like a build device that runs around the cell like a little Roomba vacuum cleaner and runs around and it vacuums up little things that aren’t really needed anymore runs around sets up I don’t need this anymore up this is some fragmented DNA we don’t need this little room bust bouncing all over the place and then it comes back to the lysosome a portion of the cell and it dumps the contents so the room but goes around pick stuff up comes back dumps it in the trash goes through recycling and then it’s food right but the other kind is called micro algae and micro algae is actually what occurs more when we are fasting you see micro Auto Fuji is more like your cells built-in pac-man visualize pac-man just opening up the mouth and little pieces of DNA and cell structure and things like that coming into the pac-man mouth and then gobble-gobble-gobble-gobble and it eats them up okay when you are in a starvation mode because you’re fasting or anything like that pac-man gets activated a little bit more now macro autopsy still occurs too but we probably see a higher degree of micro otology occur because it’s a quicker influx of food coming in for the cell anyhow that’s neither here nor there but let’s talk about what’s happening all the time in your body you see to some degree autophagy is always occurring and that means that we don’t need to be sitting here worrying about it being exclusive to fasting you see when we exercise and we move certain tissues or we’re deprived of specific nutrients at a given point in time we will have a toughie G occur at one area of our body for example our muscles might be going through Altaf G at a different point than our liver or our cardiac tissue might be going through our toffee G at a different point than our muscles right it’s just all over the place here I want you to think of it like inflammation for a minute okay inflammation is good and bad right so here’s a perfect example if you were to bump your elbow or you bumped your knee or you were to get sick right your inflammatory system inflammation is going to come to the surface to help heal the issue but if that was constantly chronically elevated it would be a problem right okay well it’s the same thing with autophagy Altaf Egeus grape is recycling cellular components but if it was happening all the time we’d waste away we’d have nothing left right so it’s the same thing we don’t want it to occur all the time so I see ways too many people that are getting concerned because they’re stopping Auto Fuji or they’re concerned about that don’t be it’s gonna be on and off all the time and we need it to be on and we need it to be off it’s not linear it’s more like a web-like kind of labyrinth of different things that activate on top of G at different times you see us depriving ourselves of nutrients during a fast might be triggering Auto Fuji at the liver level but perhaps even after we eat and we go for a walk we’re triggering Auto Fuji in the thigh muscles because we’re deprived of nutrients to the thigh at some point that’s an example but the point is it’s all over the place we have different signaling pathways and signaling pathways that turn on Auto Fuji and turn off auto Fuji a perfect example is mTOR mTOR is a growth signaling pathway whenever we workout we’re doing high-intensity activity and we’re lifting weights we have a degree of mTOR right that gets activated and tells our body to store and do build muscle and to grow that is quite literally the opposite of Auto foggy right on top of jeans recycling and dwindling down okay but another thing that’s going to induce autophagy is going to be hypoxia okay a good example of this is you’re working out to a really high intensity to the point where you’re devoid of oxygen in some places you have put yourself into what’s called a hypoxic state so when you work out at a high intensity you can only take in so much oxygen so you end up hypoxic to some degree some muscles end up in muscle cells end up not getting enough oxygen well guess what those muscle cells will go through autophagy at that point in time in an effort to conserve okay there’s not enough oxygen coming in so why should we be wasting energy operating mitochondria that don’t have the ability to even process oxygen because there’s not enough oxygen might as well kill them off or recycle it okay so that’s sort of a mitochondrial on top of G that occurs there my point with this is simple it’s that we have different signaling pathways but now let’s have a little bit of fun with it because the big trigger is going to be starvation that’s the most scientifically researched the most backed we know have all these different triggers hypoxia mTOR this that but the main one is nutrient deprivation or nutrient starvation with the big one being the total depletion of all amino acids okay so in other words when we’re not eating at all we have a very clear line of auto feejee going up okay but that’s because we have no aminos coming in now just to give you an understanding here aminos aren’t just in the protein that you eat aminos are the building blocks of protein but you might consume some asparagus and get a couple aminos and you might consume some olives and get a couple aminos you might consume some coffee and get a couple aminos or you might consume a steak and get all your aminos but the point is is at some point you’re getting all kinds of different amino acids so when total amino acids are Auto Fuji is triggered but each individual amino acid triggers Auto Fidji or disrupts otology at a different rate so let me explain this in a little bit of a simpler way with an example let’s just take two random amino acids let’s take leucine and glutamine okay leucine might have a powerful effect in terms of stopping on top of G but glutamine maybe not so much so what am I getting out with this well it means that certain things that you consume might break a fast and certain things that you consume might not but it gets more advanced than that here’s where all the variables come into play okay for example that same leucine has a different effect on muscle otology than it does on liver autophagy and that same glutamine that I was talking about has a different effect on liver auto fuji than it does on muscle auto Fuji then it does on brain otology so if you’re following me here I know this is complicated there are lots of different moving pieces each individual amino acid disrupts Auto Fuji at a different level within each and every form of tissue and cell within our body because autopsy is not a simple on/off switch it’s on and off at the cellular level of each given type of cell okay it occurs in every cell within our body so for someone to say oh this stops Auto Fuji is completely wrong because that sip of coffee that I had during the fast might have stopped Auto Fuji but where I don’t know that piece of chicken that I had definitely stopped that safa G but maybe that flavored water that had some random amino in it maybe that stopped Auto Fuji and my left toe you get what I’m saying here right one thing that’s going to help all of this make a lot of sense is looking at how our different cells process Altaf AG and go through on top of G we’ve now seen that the liver goes through Auto AG the fastest okay it tends to go throughout Safa G the quickest and it’s the most impactful probably because the liver is the most involved with metabolism right whenever we eat something something comes in the liver is handling it so when we don’t eat something we’re going to see liver Auto G her fast but another thing that we’ve noticed is that muscle cells particularly type 2 muscle cells like those that are used the fast twitch ones those that are used in strength and sprinting those tend to go throughout Tov G really quick – well what does that really mean it means that cells that are more active are going to go through Auto Fuji sooner because they are hungry all the time the more active the cell the more fuel it usually needs so when it is deprived of its fuel it’s going to panic and go through a tapa G faster now one interesting exception is going to be the brain you see the brain doesn’t go through a lot of otology even after long periods of fast it’s hard to measure a tapa G occurring in the brain why is that because as modern-day mammals our brain is probably our most powerful survival mechanism so when we’re fasting our body is going to reallocate resources from our body to our brain so again just because we don’t have otology occurring in the brain doesn’t mean that autophagy is not occurring the rest of the body so it’s a simple thing there but it gets the point across so another thing is really interesting we look at a study those published in PNAS it found that when you do a longer fast like a forty-eight hour fast you actually have a down regulation of auto Fujii later on in the Fast really what’s going on here okay so here’s what’s interesting forty-eight hour fast nice long fast you would think that you have a bunch of autophagy occurring all the time well guess what a topic G just turns on once you’re in starvation mode period it doesn’t really change a whole lot the deeper the fast that you get into once you’re actually devoid of nutrients what’s interesting is this study found that microwatt Safa G actually slowed down towards the end of a 48 hour fast and protein turnover protein degradation slowed down meaning you were actually using and wasting less protein at the end of a long fast and you were at the beginning this probably has something to do with the fact that your body has up regulated ketones and ketones are making it so that you’re not breaking down as much protein but that’s a little bit more complex we don’t need to go there so the cool thing is that macro auto AG stayed elevated the whole time and then once the fast was broken it plummeted that makes sense right Makarov tofu ji al-tofah ji at the big level was elevated but micro ATO Fuji the small cellular level was slowly going down towards the end of a fast so a point with that is that you can’t base your entire like validation of your fast on auto AG okay there’s so many other factors that are coming into play however let me go ahead and give you some quick ways that you can improve your etapa ji levels even if you’re not fasting so you can do these while you’re fasting or not of course the number one it’s going to be nutrient deprivation fast with as a little intake of anything as possible dry fasting could be really really powerful way to do it another thing that I do is while I’m fasting I consume lion’s mane so lion’s mane from Mozart of G just through other mechanisms through other genetic mechanisms and different processes if you’ve heard of for stigmatic I put a link down below for four sig Matic so it’s a form of mushroom coffee that can potentially help induce autophagy so I definitely recommend you check them out special link down below if you’re watching this video okay the other thing is lower intensity exercise just getting moving anything where you’re getting your body to have to utilize nutrients and get rid of them faster it’s going to put those tissues under stress so they go through our tofu Jie coffee the polyphenols induce autophagy again perfect example that it’s not as black and white as we think different mechanisms from the coffee that we consume are triggering out top adji at different tissue level mainly in the liver same thing with tea okay green tea induces autophagy via EGCG in the liver in the hepatic tissue they’ve noticed increases in hepatic auto phagosome when green tea or matcha green tea is consumed turmeric ‘sin otherone mainly through the regulation of nuclear factor Kappa B so when we down regulate inflammation and then for some reason autopsy seems to upregulate to a lot of different pieces that we don’t fully understand okay but the adaptogenic piece using ashwagandha using lion’s mane using reishi using these adaptogens that is one way that we are seeing at the genetic level some manipulation with some of these OTO phagosome Xin this whole stage of otology again the world is still trying to discover exactly what’s going on with this I think we’re barely scratching the surface but there are little things that you can you main thing is don’t stress about a topic she’s gonna happen when it happens you focus on the element of mastery and the mental fortitude that you can build by practicing fasting so as always keep it locked in here in my channel I’m sorry for all the lengthy explanations here but I’ll see you in the next video
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Autophagy -1 Calorie will not Ruin Your Fast Entirely – Thomas DeLauer
STOP FREAKING OUT ABOUT AUTOPHAGY!! You don’t need worry about structuring your fasting schedules around capitalizing on autophagy. You see, to some extent, autophagy is always occurring. So let me ease your autophagy worries and explain why you shouldn’t be so fixated on trying to upregulate autophagy during a fast! Let’s dive into my favorite thing… THE SCIENCE!! Enjoy and I’ll see you in the COMMENTS!
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