Does a Keto Diet cause Inflammation? | High Fat Diets vs. Inflammation | Ketosis- Thomas DeLauer
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as soon as a diet and nutrition protocol gained some momentum people come in and they start to criticize it it’s like it’s their job to come in and poke holes in something that is working the fact is when you look at the ketogenic diet it’s very very effective and whenever something is that effective you can expect a lot of criticism and that’s totally okay in fact that’s honestly what is so great about the consumer mentality today so we actually look at things and we address the issues so in this video I’m gonna address the issue of the ketogenic diet and its effect on inflammation see it’s not an issue at all in fact what it is is that the ketogenic diet does have an effect on inflammation but people really have a lot of caution with the word inflammation you see people tend to think that because the word inflammation is linked to so many diseases that it itself is a disease state so if we talk about inflammation then we’re really dancing a fine line between making a medical claim and things like that so full disclaimer we are talking about this from an educational side of things but there is a lot of research that points to the fact the ketogenic diet does have a positive effect on inflammation so let’s look at that research and let’s break it down a little bit hey if you haven’t already you’re tuned in to the Internet’s leading performance and nutrition channel all backed by science with new videos every single Tuesday Friday and Sunday at 7 a.m. Pacific time and a bunch of other videos peppered in throughout the week as well also make sure you head on over to highlight calm so you can check out the premium performance apparel that I’m always wearing in my videos so what is inflammation well let’s just give a quick breakdown so it’s like when you bump your elbow you bump your knee it gets all swollen and red that’s inflammation in the acute sense you also have inflammation going on at the cellular level and it’s sort of an immune response so whenever we have kind of free radical damage or anything going on in our bodies trauma we have that same inflammatory response but happening at a very very small level so doctors and scientists and research all over have found that inflammation is literally at the root of just about every single disease state if you look at all kinds of different chronic illnesses you back it up you see inflammation okay so when we start looking at how we can address inflammation we can of course address a lot of illnesses and a lot of pain points for people so let’s take a step back and let’s look at how the ketogenic diet does play a very powerful role on the inflammatory response within the body you see it has to do with something known as the nlrp3 inflammasome the nlrp3 inflammasome is a specific pathway and it’s bunch of proteins that basically travel along a specific pathway and trigger what are called cytokine responses specific cytokine response is like interleukin-1 beta interleukin 1 8 and just to name a couple of them these cytokines go out and they trigger additional inflammation responses throughout the course of the body so for example if you were to get sick or for example if you had an autoimmune disease all that kind of stuff so when we’re looking at the effect of what is called beta-hydroxybutyrate the main ketone body that’s produced on a ketogenic diet we see that that ketone directly inhibits its it directly slows down the nlrp3 inflammasome so therefore you have reduced amounts of those proteins up that nlrp3 proteins going throughout the bloodstream meaning less of a catalyst to trigger inflammation but that’s just one piece of the puzzle you see there’s the reactive oxygen species component as well so I know this is a lot of big words and a lot of mouthfuls but it’ll all make sense you see reactive oxygen species is literally just the free radicals that float around through our body throughout traditional metabolism we’re going to have free radical buildup it’s just the way it goes but when we look at glucose metabolism in general whenever our bodies are using carbs as a fuel source we have a high degree of free radical damage that occurs again it’s not a bad thing it’s kind of a normal thing but if we’re consuming carbohydrates all the time and we’re just utilizing glucose we have a big buildup of those free radicals when we go over to ketone utilization it burns much cleaner now full disclaimer you’re always burning glucose even when you’re in ketosis so you’re always going to have some free radical damage that’s occurring but let’s just say for a hypothetical sense that if you’re burning a hundred percent glucose you’re gonna have a hundred percent free radical damage occurring but if you reduce that down to 50 percent ketones and 50 percent glucose again your body still always has some glucose you’re gonna be at a 50 percent overall free radical damage I mean that’s simple math and it’s totally hypothetical but it gives you the illusion of what’s going on it illustrates exactly how this process works so we have less of an oxidation effect occurring we have less free radicals and it’s easier for the body to clean up and less inflammatory response so dr. Swanson at the University of California San Francisco actually conducted a study and this was pretty interesting he used something known as 2d oxy glucose to stop the actual metabolism of glucose in rats now it’s important that I mentioned that it’s with rats because it’s the right thing to do but when you use this to deoxy glucose to stop blue production in rats it forced them to produce ketone bodies and they found that whenever they produce these ketone bodies and weren’t metabolizing glucose their inflammatory markers went back down to a control basis so what that means is that if these mice had an inflammatory condition let’s say they were very very sick they could find that by literally causing their body to produce ketones by stopping glucose metabolism with two deoxy glucose that they could actually bring their inflammatory markers back down to baseline as if they weren’t sick as if they were perfectly healthy now this has to do with a particular protein is activated known as C T BP this C T BP actually modulates a specific genetic response to inflammation so it’s not just temporarily fixing inflammation like what happens when you take an aspirin or something it’s actually changing a little bit of your genetic code to actually make it so you have less likelihood of inflammation occurring overall so this is just one thing that I want a rebuttal one of the many many holes that people are trying to poke at the ketogenic diet again something gets popular it’s gonna end up having some criticism it’s all good it just makes for some great content for me to create on this channel so as always to keep it locked in here my videos you have ideas for future videos or this question thing you want answers to put them down below in the comment section see you soon
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Does a Keto Diet cause Inflammation? | High Fat Diets vs. Inflammation | Ketosis… In this segment, Keto Expert, Thomas DeLauer explores high fat diets and their relationship to inflammation.
bHB & Inflammation-
beta-hydroxybutyrate can block what’s called the NLRP3 inflammasome, an immune system receptor linked to inflammation
The NLRP3 inflammasome reacts quickly to threats to the body, such as toxins, infections, or too much glucose
While helpful in many cases, this receptor can be activated too much if we’re constantly exposed to inflammation, like from eating inflammatory foods every day
By triggering ketosis, we may be able to help reduce how much the NLRP3 fires in the body
A ketogenic diet could be beneficial for a number of types of pain, including neuropathic pain, and inflammatory pain Compared to glucose metabolism, ketone metabolism produces fewer reactive oxygen species, which are known to contribute to inflammation.
Ketosis & 2-deoxyglucose (2DG): Brain Inflammation-
Study from: Raymond Swanson, MD, a professor of neurology at UCSF, chief of the neurology service at The San Francisco Veterans Affairs Medical Center, and senior author of the new study.
Researchers used a small molecule called 2-deoxyglucose, or 2DG, to block glucose metabolism and produce a ketogenic state in rats and controlled laboratory cell lines.
They found that 2DG could bring inflammation levels down to almost control levels – The 2DG molecule stopped glucose from metabolizing and created a ketogenic state in rodents with brain inflammation as well as in cell cultures. Levels of inflammation were drastically reduced – almost to healthy levels – as a result. Also, they found that reduced glucose metabolism lowered a key barometer of energy metabolism – the NADH/NAD+ ratio – which in turn activated a protein called CtBP that acts to suppress activity of inflammatory genes. The researchers designed a drug-like peptide molecule that blocks the ability of CtBP to enter its inactive state – essentially forcing the protein to constantly block inflammatory gene activity and mimicking the effect of a ketogenic state. The study has applications beyond brain-related inflammation – presence of excess glucose in people with diabetes, for example, is associated with a pro-inflammatory state that often leads to atherosclerosis, the buildup of fatty plaques that can block key arteries.
1) Ketosis for Reduced Inflammation. (2017, July 13). Retrieved January 04, 2018, from
2) Masino, S. A., & Ruskin, D. N. (2013, August). Ketogenic Diets and Pain. Retrieved January 04, 2018, from
3) UC San Francisco. (2018). How Ketogenic Diets Curb Inflammation in the Brain. [online] Available at: n