Collagen has Interesting Effects on Sleep & Brain Function

Collagen has Interesting Effects on Sleep & Brain Function

Collagen has Interesting Effects on Sleep & Brain Function

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College in here collagen their collagen on the shelf collagen on the internet okay it’s everywhere so let’s forget about the marketing for a second let’s talk about how collagen actually does some pretty interesting things when it comes down to helping you sleep and overall helping out your brain you see the cool thing is we’re starting to scratch the surface on some really interesting stuff with collagen and as we’re learning that our food supply is really losing a lot of its quality we’re finding that more and more people are deficient in the kinds of collagen that they need to feel healthy to have good brain function and to actually end up burning fat and building more muscle the way that they want to hey but first off I want to make sure that you hit that subscribe button so you can always tune in to my channel and get three to five awesome health topics each and every week to get you through your plateaus and get you to be your best self also if you’re already a subscriber please hit that little bell so you can turn on notifications all right so bear with me because I have to give you the quick breakdown of what collagen is for those that don’t know you see collagen is a simple protein within the body but it makes up a lot of the things that are kind of random we’re talking like the skin we’re talking about organs we’re talking the nails we’re talking the corneas really random parts of the body even our blood vessels so it really kind of gives the structure to a lot of things so what we’re finding though is that there are more than just one or two types of collagen we actually have 28 different types of collagen that we know of now we’ll probably find out even more and the cool thing is is that collagen is very bioavailable and biofloc scible so collagen peptides have the ability to come into the body and create the kind of collagen one through 28 that we truly need within the body but what I really want to focus on in this video is how collagen affects our sleep and affects our brain because it’s not the typical just scaffolding that we’re always thinking collagen is it’s really got a lot more of a biomechanical and a biochemical process that isn’t talked about a whole lot so the first thing I want to talk about is what is called the glycine link you see when we look at collagen it’s made up of three amino acids glycine proline and hydroxyproline glycine makes up about 1/3 of collagen in the first place and when it comes in a collagen food form it’s truly a very bioavailable form of glycine which means the body can synthesize and use it better well what we’re finding now is glycine has a very powerful effect in the brain in our brain we have a portion called the hippocampus the hippocampus is what’s responsible for you being cognitively aware alert okay it gives you that memory it gives you that ability to articulate right now I am heavily using my hippocampus to focus on filming this video so that’s what really makes things interesting but right next to the hippocampus and right next to the receptors for glycine in the hippocampus we have gaba and glutamate receptors now if you’ve seen other videos of mine you already know what this is but I’m gonna give you a quick breakdown GABA stands for gamma amino butyric acid and it is the portion of the brain the system within the brain that allows us to relax and get into that sort of seduced kind of like a sedative state okay then we have the polar opposite which is called the glutamate system the glutamate system is exit Ori so when we have the glutamate system activated our brain is like on hyperdrive and it actually burns itself out so what we’re finding through very conclusive evidence with the journal of front cell Neurosci is that glycine plays a key role in what’s called cell migration but also has a very very powerful effect on instigating gaba within the body so what that means is glycine is now being shown to have the body produce more of this gaba amino butyric acid allowing us to be in a more seduced relaxed State and taking us out of that glutamate state so the glutamate state again you’re on hyper drive you’re super anxious and what ends up happening if you’re high in the glutamate system is you end up borrowing from tomorrow and the next day to use today you end up using a lot of the energy that you’d use tomorrow and the next day right here in the present because your brain is on hyperdrive so we want to balance it out we want to get into that gaba state so our brain can actually restore and recover itself now the other cool thing is now that we’re seeing this glycine inducing this gamma amino butyric acid within the body means that we can get into a deeper sleep but it’s better than just that if you’re someone that can’t get a whole lot of sleep simply because priorities end up overwhelming you well the cool thing is gaba allows you to be ushered into a deeper sleep faster so i’m not saying you should try to function on four hours of sleep but if you have high levels of gaba and lower levels of glutamate because of this cell migration due in part to glycine you’re gonna get better sleep in a short amount of time alright so that bridge is now crossed now let’s talk about some crazy signs so stick with me on this I know I’m already blowing your mind with this glycine stuff but now I want to get into extra matrix stuff the heck is that alright the extracellular matrix is just what it sounds like it’s the scaffolding it’s the scaffolding that is outside of cells so we have non cell portions of our organs of our skin everything like that but without the extracellular matrix they don’t have the skeleton they don’t have the scaffolding the whole em together so you just kind of like flop all over themselves with nothing to hold them again so what we’re seeing now is that this physical scaffolding that it once was is actually powerful when it comes down to eliciting biochemical and biomechanical signals within the body so this scaffolding actually triggers the body to do different things for example biomechanically what it would do is it sends a signal that the muscle is growing so the scaffolding can actually change and accommodate the growth so if you’re trying to build muscle you’d never be able to build muscle if the scaffolding didn’t grow and the scaffolding would never grow if it didn’t have biochemical and biomechanical signals coming from collagen 6 specifically so that’s pretty fascinating stuff and then it breaks down even further you see we actually can talk about the brain function here a brain needs these signals as well so we end up having what are called cytoprotective effects what we’re finding now is that collagen 6 directly affects apoptosis which is premature cell death and slows it down it keeps cells from dying prematurely it also prevents free radical damage which is a very good thing but the other really cool thing especially cool if you’re someone that practices intermittent fasting is that it helps regulate etapa G on top of G is the natural cell recycling that occurs okay and when we’re fasting it’s expedited we’re really recycling cells meaning old cells that are decrepit and just worthless end up getting consumed by cells that are thriving to thrive even more feed the stallion starve the pony don’t really starve the pony that’s kind of sad but in reality this is what we want so collagen 6 stimulates this and I know I get excited about this but anything that’s related to fasting I get kind of jazzed up about so anyhow the science is just now beginning when it comes down to what collagen can do and our food supply is so tainted with chemicals and with just other pesticides and products and we’re not getting the true collagen that we used to get even from our meat sources because they’re soda natured and degraded so people are getting deficient in collagen so I I recommend that you start looking into it which ever way you choose to but as always I want to make sure that you keep it locked in here on my channel keep it locked in with these videos so that you can make sure you’re constantly educated and know what’s good for you I’ll see you in the next video

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Collagen has Interesting Effects on Sleep & Brain Function

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Collagen has Interesting Effects on Sleep & Brain Function – Thomas DeLauer


Scientists from the Gladstone Institute of Neurological Disease (GIND), UCSF, and Stanford have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta (Aβ) proteins, which are widely thought to cause Alzheimer’s disease (AD).

The Gladstone team had profiled changes in gene expression using DNA microarrays, which provides an unbiased method for identifying key biological pathways.

By comparing all of the genes that are active in disease and normal tissue, one can get valuable information on new pathways and potential therapeutic targets.


This analysis revealed the striking increase in collagen VI in the brains of mice that model AD.

Building on this initial finding, the team examined brain tissue from AD patients and normal non-demented humans and found that collagen VI expression was also higher in the AD patients.

They further discovered that the cellular source of the collagen VI in the brain was neurons, the very cells that the disease attacks and that we all need to think and remember.

The scientists carried out a series of informative cell culture experiments. These experiments revealed found that Aβ added to neurons grown in culture increased the expression of collagen VI and that this process involved the immune regulatory cytokine TGFβ (transforming growth factor beta receptor).

The team discovered that increasing the amount of collagen VI in the cultures effectively protected the neurons against Aβ toxicity.

This protective effect suggests that increased neuronal production of collagen VI is an important component of the brain’s defense against Aβ.

Collagen VI

Distinctive feature of this protein is its unique supramolecular assembly, which is driven by a multi-step process that leads to the formation of the characteristic beaded microfilaments network in the extracellular matrix (ECM).

Collagen VI represents a remarkable extracellular matrix molecule, and in the past few years, studies of this molecule have revealed its involvement in a wide range of tissues and pathological conditions.

The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and homeostasis.

Collagen, Glycine and Brain Function

Roughly one third of collagen is composed of glycine, a non-essential amino acid that is key to brain health.

Glycine receptors are found in the hippocampus, along side GABA and glutamate receptors.

Conclusive evidence, in the Journal of Front Cell Neurosci, supporting glycine in a role in the control of cell migration. This role seems to be complementary to the activation of GABA receptors that have long been known to contribute in this process.

In the brain and nervous system, L-glycine acts as an inhibitory neurotransmitter.

Glycine tends to induce a sedative or inhibitory effect, while also being capable of improving mood and cognition.

The hippocampus, part of the limbic system is a central means to processing memory, emotion, and may even be a regulator of the autonomic nervous system.

According to the journal of Biological Psychiatry, scientists have even studied the link between glycine and schizophrenia, finding that treatment with the amino acid improved their positive, negative, cognitive and general psychiatric symptoms.


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3) Cescon M , et al. (n.d.). Collagen VI at a glance. – PubMed – NCBI. Retrieved from
4) The extracellular matrix at a glance. (2010, December 15). Retrieved from
8) Collagen VI at a glance. (2015, October 1). Retrieved from
9) Why You Need Glycine, Hydroxyproline, and Proline in Your Collagen Supplement | Natural Force. (2018, March 23). Retrieved from
10) Tsai G , et al. (n.d.). Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. – PubMed – NCBI. Retrieved from
11) Glycine receptors and brain development. (n.d.). Retrieved from /

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