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this is caffeine this and the adenosine receptor Hey look at me I’m caffeine hey I’m an adenosine receptor Hey look you’re blocked okay in all seriousness let me explain some science basically I want to explain how caffeine works in the body but I also want to explain the science of the caffeine withdrawal and how you can get over having too much caffeine but first and foremost I want to break down something simple caffeine is not that bad it’s not bad for you in fact caffeine is not even technically a stimulant it’s technically a natural stimulant enabler and if you listen this video and you’ll listen to me through my entirety throughout this entire video you will have a solid understanding of exactly what I mean and how you can really control your caffeine intake to really work for your advantage and also help you burn some fat what caffeine is is an adenosine receptor antagonist all that that means is it blocks the receptor that normally takes on adenosine well what does that mean well adenosine is something that pills up during the course of the day and eventually by the end of the day makes you tired you have these adenosine receptors in this case the lettuce and you have adenosine adenosine piles up throughout the course of the day in the brain and eventually gets the receptor and when it hits the receptor it makes you tired and then you go to sleep and the receptors clear up and then they’re ready for caffeine again the next day so basically you have this adenosine build-up all day and then all of a sudden you get tired but what caffeine is is it looks just like adenosine but it’s not it blocks the receptor so the adenosine in this case it’s the other Apple floats around and can’t get in well this basically has taken the place of the adenosine to simulate it it’s an impostor the only difference is that the caffeine unlike adenosine isn’t making you tired you see now you have a buildup of all this extra adenosine in the brain because it can’t hit the receptor because caffeine is occupying it and it makes you wired why does it do that because all the extra adenosine causes the adrenals to produce more adrenaline more epinephrine more norepinephrine all the catecholamines that get you wired and to add insult to injury it also causes a big surge in dopamine which makes you feel good which quite honestly is why a lot of us get addicted to caffeine because we like to feel good so hope that that makes sense it’s a brief explanation of how it actually works when it comes down to really giving them energy you see it’s your body’s way of responding to something occupying a receptor it’s not like phentermine or these direct stimulants like even clenbuterol if things that affect your central nervous system all this is is something that blocks the receptor and allows you to have energy by your body’s own ability now what exactly happens when we develop a tolerance to caffeine well remember those adenosine receptors I was talking about well the more that they get occupied the more that your body and your brain starts to say well wait a minute something’s wrong here so it needs to produce more of them all of a sudden instead of having maybe a thousand adenosine receptors you have 1500 your body has produced more in order to accommodate more of what is binding to it you’re never going to trick your body a lot of people will say shock your body trick your body this that forget it you’re not gonna outsmart all the things that your body can do it’s amazing so that is how a caffeine tolerance builds up eventually you get to a point where you just need copious amounts of caffeine to have the same effect as you did last week or the week before so how do you get over that well it’s actually pretty easy it’s actually pretty easy to develop a tolerance in the first place though even the Journal of Clinical Investigation found that it only takes between one and four days to develop a tolerance so it’s really pretty easy but here we’re going to talk about the withdrawals and how you can come off of caffeine or at least reduce the amount that you’re taking in so we have to understand that withdrawals really only affect about 50% of people a lot of times it’s a placebo effect but there are a small population of people like 13% on average that gets so affected by caffeine enthralls that they’re almost debilitated they can’t even work so there are a subset of people that really get affected but a lot of people when they end up having a placebo effect in fact there was a study that was actually done I don’t have it right in front of me but it showed that those that are addicted to coffee that were given decaf but not told it was decaf ended up not having withdrawal symptoms therefore showing that a lot of it could just be a placebo effect the headache and all that stuff that you might get with a withdrawal that comes from the cerebral blood flow velocity basically it’s the change in the vasoconstriction the basilar dilation that’s causing a big surge of blood to rush to your brain that’s all it is that’s why you’re having a headache there’s simple things that you can do to modulate that okay you can take anti-inflammatory compounds like turmeric you can take some fish oil like omega-3 that’s gonna actually cross through the blood-brain barrier and reduce the inflammation in your brain those are some simple holistic ways that you can combat that but what about actually coming off the caffeine how is that gonna work well you’re not gonna like this first answer and that’s gonna be going cold turkey just quite honestly again studies have shown that it really only takes about three or four days to bounce back from caffeine with girls for your body actually reduce the amount of adenosine receptors that it has again so you have that nice easy tolerance of caffeine where you can have one cup and be good to go but the other thing that you can do is something that I do I go fully leaded caffeine then one week I’ll do half caff where I’ll do half decaf half regular and then the next week I’ll go full decaf so it’s like I’m sort of kind of indoctrinating decaf back into my life I try to do that about once every three to four months right now speaking honestly I’m having more caffeine than I would like to be having so it’s probably about time for me to start that process in fact maybe the doing this video is a prompt for me to start that tomorrow something that I do about once every three or four months that’s what I recommend for you but there is something new there’s something out there that’s known as rudik carpet and I’ve been studying it a lot lately but this route of carpet is supposed to do is supposed to enhance the metabolism of caffeine in your body it speeds it up and there was a study that actually took a look at this so this study was published in the archives of pharmacal research and it was simply studying the effect of ruta carping on caffeine metabolism and the results were pretty darn simple well what this study found was that ruta carpi not only increased the metabolism of caffeine but also increased metabolism of theophylline also theobromine and her accent thing all which have to do with that energy and the adenosine receptors and it did so simply by increasing what is known as cy p a2 and cy p e1 these are basically just compounds that help break down caffeine and metabolize it faster so what does that mean it means in early stages we’re seeing that Lucar peen could be something that allows caffeine to get out of your body faster and allows the adenosine receptors to come back to normal as soon as possible now I don’t even know where to tell you you could find this stuff but the fact is the science is pretty interesting so the whole purpose of this video is to explain to you that caffeine isn’t as bad as you think it is it’s not this crazy stimulant and as long as you’re not going over four or five six hundred milligrams per day you’re really not any danger as long as you’re keeping your heart and check and you’re not doing anything crazy the one thing I will say is keep hydrated because caffeine is a vasoconstrictor and is also a diuretic so if you’re not hydrated then you’re just messing up a multitude of other things they’re gonna slow down your fat loss so if you want to get the fat burning properties of caffeine where it’s mobilizing fatty acids you got to make sure you’re hydrated you got to make sure you’re not overdoing it and you got to make sure that you’re taking care of your lettuce and your Apple so as always keep it locked in here on my channel and if you have any ideas for future videos be sure to let me know in the comment section below and I will see you in the next video
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Caffeine: How to Beat Withdrawals- Thomas DeLauer… How it Works and Tolerance:
Caffeine is molecularly similar to that of adenosine, a molecule that builds up and causes you to feel tired – builds up throughout the day and is depleted during sleep; adenosine thus facilitates sleep and dilates the blood vessels, probably to ensure good oxygenation during sleep. So, when you ingest caffeine, the molecules bind to the receptors in the brain normally used by adenosine. Caffeine Is an adenosine-receptor antagonist; meaning it binds to the same receptors, but does not slow down neural activity. In other words, once caffeine is locked to adenosine’s receptors, there’s no place for adenosine to accumulate – Which prevents it from building up and making you sleepy. All of the extra adenosine that’s floating around causes the adrenal glands to secrete adrenaline – so it increases your attention level and boosts energy. Also, it increases the production of dopamine in the brain’s pleasure circuits, giving you that feel-good sensation.
Caffeine is not a direct stimulant, but rather a stimulant enabler; lets our natural stimulants run amuck – usually lasts from 4-6 hours.The blocking of adenosine receptors by caffeine causes your brain to produce more and more receptors to make up for them – this means that you’ll have to keep upping your caffeine intake in order to bind to all the new receptors (1,2)
According to a study published in The Journal of Clinical Investigation, caffeine tolerance occurred after just 1-4 days among their study participants. They measured this by noting the increased blood pressure, increased heart rate, and plasma epinephrine levels – After 1-4 days these levels were back to their baseline. (3)
Withdrawals: Caffeine causes vasoconstriction, but when we go through a withdrawal, a re-widening of the vessels increases blood flow to the brain, leading to a withdrawal headache (4,6)
Reduce Withdrawals: Caffeine withdrawal symptoms typically begin within 12 to 24 hours after discontinuing caffeine, peaking during the first two days, and can last all the way up to day nine – however, those that consume incredibly high doses of caffeine can experience symptoms for longer.
Cold Turkey: Going cold turkey can be effective, however, it can be crippling to many and is not the ideal way to reduce withdrawals. Slowly Reduce Intake- Slowing reducing caffeine intake day by day is the preferred method – the slow withdrawal of caffeine from the body will eventually result in the decrease of the extra adenosine receptors.
Common Solutions:- Replace caffeinated beverages with herbal teas to soothe symptoms and counteract dehydration, which can worsen headaches and withdrawal symptoms. Get extra sleep to combat fatigue and grogginess.
Rutaecarpine: Rutaecarpine is an extract from the herb known as Evodea and has been shown to help rid the body of caffeine. A study published in the Archives of Pharmacal Research looked at rutaecarpine’s effect on caffeine metabolism in rats. Since mice and humans metabolize caffeine very similarly, the effects of rutaecarpine in regards to human caffeine metabolism are likely the same. The study found that rutaecarpine increases the metabolism of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 (metabolism of xenobiotics; substances foreign to the body) and CYP2E1 in rats. Rutaecarpine speeds up the rate at which caffeine is broken down and removed from the body – cleansing caffeine from the body eliminates the side effects of caffeine much quicker (5)
1) THE BRAIN FROM TOP TO BOTTOM. (n.d.). Retrieved from
2) How Does Coffee Affect Your Brain? – Business Insider. (n.d.). Retrieved from
3) Tolerance to the humoral and hemodynamic effects of caffeine in man. (n.d.). Retrieved from
4) BODILY INTERACTION FOUND TO EXPLAIN CAFFEINE WITHDRAWAL HEADACHE – NYTimes.com. (n.d.). Retrieved from
5) Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats | SpringerLink. (n.d.). Retrieved from
6) Caffeine Withdrawal Headache Explained: Your Brain On — And Off — Caffeine. (2009, May 9). Retrieved from m