Magnesium Absorbency: Our Clinical Trial Results- Thomas DeLauer
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magnesium is super super hot right now and I thought I’d do this video to talk about a clinical study that I was actually a part of that had to do with magnesium uptake and magnesium levels in the body so super super proud of this published here in 2018 so brand spanking new but anyway the reason that I want to talk about this is because so many people have been talking about different magnesium products different forms of magnesium and how they absorb in the body and how they’re actually utilized so let’s get right into what more of the common magnesium’s that you would see out on the market are and let’s talk about how they act in the body so first of all magnesium can be a little bit sketchy because a lot of times the magnesium ends up not being absorbed very well now if you’ve ever taken magnesium sulfate which is also known as Epsom salt you know that it actually makes you go to the bathroom quite fast so it causes an osmotic effect within the colon what that means is that it ends up changing up the sku of how water is in the colon versus out of the colon which can throw off mineral balances even more and cause you to have well pretty loose stools and quite honestly feel very very uncomfortable so when you look at a lot of different magnesium products that are out there on the shelves and most stores you’re looking at things like magnesium oxide magnesium carbonate and the problem is these have a very low availability within the body which means they end up disturbing that overall osmotic balance that we have in the colon and the small intestine so that bioavailability that is low ends up causing all the GI discomfort that you would ordinarily get with most magnesium so what we did is we wanted to take a look at the different kinds of magnesium and how they’re actually absorbed so when you look at what physicians usually recommend for like magnesium deficiency issues and things like that they usually recommend magnesium a lake a magnesium male eight is a lot more expensive but it does have a better bioavailability so what we did is with jigsaw SRT we took a look at something called die magnesium male eight okay so male eight just means that’s bound to male ik acid so when you look at die magnesium male eight what we did is we took two magnesium ions and bound them to malic acid so we had a very bioavailable very absorbable form of magnesium then additionally added an SRT component to make it sustain release so that it actually took a longer period of time to absorb so you weren’t just getting this massive influx of the body didn’t know what to do with so then we get to the study let’s talk about what we did in Scott still here that was just published in 2018 so the study was published in the Journal of the American College of nutrition here in 2018 and it’s called the Scottsdale magnesium study when we took a look at absorption cellular uptake but also magnesium deficiency symptoms to see if magnesium was truly absorbed and how it affected symptoms based on a questionnaire for participants that started the study was done over a period of 30 to 90 days we took 91 participants so 53 participants that took magnesium SRT from jigsaw okay 500 milligrams and then the rest took a placebo so there’s a few things that they wanted to measure her after they took the magnesium supplement they wanted to measure of course their serum magnesium which is the overall levels of magnesium that ultimately ended up in their body then they wanted to look at what’s called RBC magnesium okay RBC magnesium stands for red blood cell magnesium this is very very important what this is is this is the magnesium that is actually building up in your body and getting inside your bones okay getting with the red blood cells in the marrow getting into where it needs to go to actually have a long-term effect on the body so we wanted to look at that over a longer period of time serum magnesium can be looked at over a shorter period of time that’s more indicative of how well is a product being absorbed or how well is a mineral being absorbed in a shorter amount of time so between four and eight hours after taking the magnesium is when they measured the overall serum magnesium but after 30 and 90 days is when they truly looked at the RBC to see how it was really building up within the body so they found that there was a 22% increase in serum magnesium levels okay this is pretty phenomenal because before now there wasn’t any way to really prove whether a magnesium was absorbed or not so when we have a 22% increase in serum magnesium that means that we are literally getting 22 percent more magnesium in our body ready to be used okay now here’s where it gets really fascinating there was over a thirty percent increase in RBC magnesium over time again that RBC magnesium is magnesium that’s actually getting into the marrow and ultimately being able to be used by the body okay competing against calcium helping your body have a little bit more of a calming effect versus the exit ori effect from excess calcium ions going through the body so a very very powerful that we saw that okay then at the beginning of this study they did give all the participants a questionnaire okay they wanted to note their magnesium deficiency symptoms okay we’re talking about things like leg cramps we’re talking about things like your inability all these little things that go along with magnesium deficiency then at the end of 30 and 90 days they measured him again they had them fill out another questionnaire and see how their overall symptoms were doing well guess what after 90 days 63 percent decrease in magnesium deficiency symptoms that is powerful so for someone that is normally having leg cramps or someone that is normally having the issues that arise with magnesium deficiency we were able to prove with this Castillo magnesium study that you can start to reduce magnesium deficiency symptoms so if you combine that with a cumulative buildup of magnesium in the body you can start to get the results that you want so hopefully this clears up a little bit about magnesium and how it truly works in the body we’re super proud to have published this study super proud to be able to be a part of true science and actually changing lives and I also want to add that ninety-one percent of the participants that participated in this study tolerated the product very very well meaning they tolerated jigsaw magnesium SRT exceptionally well just so that you know that is very very rare in a study you don’t usually see something that well tolerated usually it’s like a 70 80 % stick through rate most people end up falling off so not only do we find that it has amazing effects in the body we also found that it’s well tolerated amongst most people and to add one more thing to make this really really powerful when you’re normally looking at a clinical study usually you’re looking at a one and a half times better than placebo effect well in this case five times better than placebo so most pharmaceutical companies when they’re doing any kind of clinical trial all they are looking for is the drug to be one and a half times better than placebo and that it’s kind of a gold standard well mag SRT five times better than placebo so as always make sure you’re keeping it locked in here in my channel I did put a link down to jigsaw magnesium below you can get it on Amazon this isn’t a hard core product push it’s just to tell you about an amazing amazing thing and an awesome study that I’ve been a part of so link is down below but as always keep it locked in here in my channel want to see more magnesium content hit it in the comments below I’ll help you understand how it works in the body
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Magnesium Absorbency: Our Clinical Trial Results- Thomas DeLauer…
Study published in the Journal of the American College of Nutrition in 2018 – it evaluated the absorption, cellular uptake and clinical effectiveness of MagSRT vs. a placebo in a human clinical trial of 91 people. MagSRT is a time-release Magnesium supplement from Jigsaw Health, containing dimagnesium malate with vitamins B6, B12, and folate.
A standard clinical population of 91 adults participated in a placebo-controlled study carried out at two clinics: 53 individuals received MagSRT, containing 500 mg dimagnesium malate and vitamins B6, B12, and folate, while the remaining individuals received a placebo. Baseline serum magnesium, red blood cell (RBC) magnesium, and magnesium status questionnaire scores were collected prior to trial initiation. Serum magnesium was measured 4 and 8 hours after participants ingested 2 supplemental tablets (250 mg magnesium) or 2 placebo tablets. After 30 days, RBC magnesium was evaluated and participants completed the magnesium status questionnaire. A subset of MagSRT participants (24) continued the trial for 90 days. Both RBC magnesium and the magnesium status questionnaire were evaluated at 90 days.
MagSRT was well-tolerated by most individuals, with 91% of participants completing the 30-day trial – individuals who continued the trial for 90 days, reported no side effects.
Overall symptomatology, evaluated using a magnesium status questionnaire, improved 28% over 30 days and 63% over 90 days. Red blood cell (RBC) magnesium increased 6% and 30% over 30 and 90 days, respectively.
-Serum magnesium increased by 22% with MagSRT (compared to placebo)
-Red Blood Cell magnesium increased by 30% with MagSRT (compared to placebo)
-Magnesium deficiency symptoms decreased by 63% with MagSRT (compared to placebo) (5)
Quatrefolic (Folate, Vitamin B9)
Quatrefolic (5-MTHF, folate) is an active form of Vitamin B-9, folic acid – as for many people, it is difficult to convert folic acid into folate – needed for cell division, to make DNA, etc.
Vitamin B6 (P5P, Pyridoxal-5-Phosphate)
P5P (Pyridoxal-5-Phosphate), the active form of Vitamin B6, performs over 30 critical enzymatic reactions in the body, including the manufacture of serotonin and dopamine in the brain.
The inactive forms of B6 have to be converted by the liver to the active form, P5P – since Vitamin B6 needs to be converted into its usable form, MagSRT provides it in its active P5P form
Vitamin B12 (Methylcobalamin)
Methylcobalamin is the active form of B12 and is a necessary cofactor for your body’s ability to properly methylate. Methylation is a cycle that occurs in your body billions of times every second – it’s the process of taking a single carbon and three hydrogens, known as a methyl group, and applying it to critical functions in your body – repairing DNA, turning on and off genes, and fighting infections.
1) Retrieved from
2) Weiss D , et al. (n.d.). Scottsdale Magnesium Study: Absorption, Cellular Uptake, and Clinical Effectiveness of a Timed-Release Magnesium Supplement in a Standard Adult Cli… – PubMed – NCBI. Retrieved from
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