Don’t Hate mTOR! (Even though it’s the opposite of Autophagy)

Don’t Hate mTOR! (Even though it’s the opposite of Autophagy)

Don’t Hate mTOR! (Even though it’s the opposite of Autophagy)

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mTOR is what grows your muscles but mTOR is also what is decreasing your longevity you see we always talk about otology and if you do watch my videos frequently then you know what auto fit is auto AG is where your cells are recycling just weaker components of themselves and organelles so basically they just kind of recycle a portion of a cell when you’re in starvation mode or anything like that well to give you a simple example mTOR is the opposite so in today’s video I want to just give you a lay of the land of what import is and how it’s working inside your body and when you want surges of mTOR versus circuits of auto fuji you see within our bodies we have opposing biological processes and what I mean by that is we always have a balance of growth and we always have a balance of longevity so growth and longevity compete with each other and eventually one wins right okay so we obviously want longevity now mTOR is related with growth the whole purpose of mTOR is to activate growth which is in essence the opposite of longevity so you would think in theory that mTOR is really really bad we don’t want em tor because it decreases longevity but again we all come back to when we want it when we want growth so I want to break this down in some simple examples that you have an understanding exercise okay that triggers mTOR it triggers growth in the skeletal muscle growth okay fasting that inhibits mTOR triggers Auto Fujii that is longevity then insulin activates mTOR insulin is growth mTOR is growth so whenever we eat we activate mTOR growth versus longevity same with branch chain amino acids okay you take a branched chain amino acid supplement because you’re trying to build muscle you’re also activating M torque which means you’re activating growth then we have another thing called sirtuins now if you’re a science nerd you notice or – it is but a sirtuin is sort of an anti-aging compound in the body okay sirtuins are sort of the opposite of mTOR as well so fortuyn’s being longevity the opposite of mTOR which is growth the point is we have these things okay em tours all about growth and on top of G is all about longevity but how is this process working within your body and what do you need to know as a lay person that’s just trying to get through life and live for the longest amount of time possible well mTOR is complicated okay we have mTOR one we have mTOR two and they do different things in fact if you look at the image that’s up on the screen right now you’ll see that mTOR is pretty complicated what this image is depicting is it’s showing how imp tor stands in the way or impedes or allows certain processes to happen within the body you see here’s how it works mTOR is what is called a kinase okay and a kinase is something interesting and that it takes a phosphate group it takes a phosphate molecule rather from ATP what this means is it basically takes a phosphate molecule from energy creation and it randomly throws it along with other proteins so basically a kinase like mTOR regulates other proteins and therefore determines what the downstream paths are downstream result is to make this very very simple basically mTOR is something that dictates what direction the body goes and where let me give you a very clear analogy let’s say for example you have a river and a river that is flowing super smoothly with no impedance whatsoever right it’s just flowing along okay then all of a sudden you take a big giant pillar or a big rock and you plop it smack right in the middle of the river so the rivers gone from having this clean flowing just life – all of a sudden having a disturbance and disruption where it has to divert water around the rock to the right and around the rock to the left well suddenly you’ve taken the energy in the force of that River and you’ve concentrated it in one direction and in another direction that rock or that pillar is mTOR okay it came in it disrupted a protein and it all depends on where it hits in terms of that protein and it changed the direction of the downstream path so it diverted water off to the right and left which in this case is growth off to the right and left so for instance when you work out you trigger mTOR in the skeletal muscle tissue that’s like putting a rock you know a specific area of the river that’s gonna allow it to grow muscle okay it’s hypothetical obviously so you can see how mTOR is not necessarily as activated in your entire body it’s activated in specific spots and it all depends on where it puts that phosphate group or phosphate molecule within a given protein so depending on where it adds it it can either activate different processes or inhibit different processes you see put the rock in the middle of the river and it’s going to inhibit otology but it’s going to activate growth so I know that’s a little bit complicated but I hope it all makes sense hey I do want to stop for one second if you haven’t already hit that red subscribe button please do it if you haven’t hit that Bell icon I encourage you to do so as well so you never ever ever miss a beat and also all the things that we’re talking about it’s all about keeping in balance okay so if we have mTOR activation that’s really high obviously that’s pro-growth and anti longevity I just want to make a note that there’s things that you can implement into your life to increase autopsy to balance the mTOR okay we’ll talk about that a little bit more but like green tea matcha green tea is probably one of the best ways throughout the course of the day that you can at least encourage otology to occur and if you got em tour and etapa g always in a constant balance so if you’re doing things like lifting weights and working out you want to be sipping on green tea so that you can at least crush some of the mTOR levels that might go on long term okay now I’ll talk a little bit more about that later if you guys do want to check out some of the matcha that I recommend there’s a special link for yugioh matcha down below a 100 80 year-old matcha company they sponsor a lot of videos on my channel and they’re super super awesome super clean and they have these little to go packets that you can just like literally put it in some water put it in some almond milk whatever you want to do and just be on the go and have your matcha packet so special link down below in the description so when we look at mTOR as sort of this live hot die young sort of thing it gives us a little bit of an understanding okay a very extreme hypothetical example would be let’s take some of that’s only focused on muscle growth right only focus on anabolism they focus on how big can I get my muscles well obviously they’re going to focus only on that and eventually there’s no focus on longevity they’re probably going to I younger right okay it’s just like we have to look at that so the live hot die fast die young kind of thing truly is there we want mTOR we just want it at specific points in time we want import after workout we want mTOR when we’re trying to build muscle but we want to balance it with otology employ is not bad we need to have these balanced cycles for every little bit of emptor activation that we have we have growth which means we have waste which means that we need to have proper breakdown – okay additionally looks like said we want to have these surges all the time it’s also funny to think that too much auto Fuji is bad too in fact catabolism in elderly patients is one of the biggest risk factors for death so what that means is that if you have too much of the opposite of mTOR it’s a big risk factor for death just as much as mTOR is a big risk factor for death if you have too much like it’s never really been proven that mTOR is a risk factor for death it’s all just a balance once again if you focus only on growing new tissues ie cancer things like that obviously you’re gonna have a problem okay so it’s all about the balance so how you do that is up to you meditation fasting in conjunction with periods of mTOR sipping on green tea to induce autophagy while also having meals at certain times to induce mTOR and one last very important thing that we need to realize is that we are not just some homogenous blob that has an on or off switch and what I mean by that is we don’t just activate mTOR in our entire body it’s not how it works just like we don’t activate auto Fiji in our entire body all at once okay when we’re fasting for instance we trigger hepatic auto Fiji first that means auto Fiji within the liver the liver cells start to regenerate first because they’re the most active in metabolism so the second that they get a break they start to recycle well believe it or not you could have mTOR being activated in your brain at that very point in time that your liver is going through Auto eg and also when you’re working out and you’re inducing skeletal muscle mammalian target of rapamycin there’s a very good chance because blood flow and nutrients are going through the muscles that your brain is in a state of auto fiji or not having mTOR activated so it’s not like you have mTOR just on and like so the point saying this is eating isn’t bad working out isn’t bad activating mTOR isn’t bad I’ve talked to people that simply think that if they have mTOR being activated that they’re building cancer cells it doesn’t quite work like that however if you live your life in a constant mTOR state because you’re constantly eating and you’re constantly doing things like that then yes there probably is some indicator I’m not a doctor that out there it’s showing that yes you were probably building cancer cells and you’re probably promoting the growth of things that shouldn’t be there the point is keep it balanced sipping green tea fast regularly but don’t be afraid have a big surge of food don’t be afraid to have a big bolus of protein to trigger mTOR so you can actually recover so the goal of this video was to help people not be afraid of mTOR if you want a more in-depth breakdown of mTOR I’m happy to do one just let me know down in the comment section below and I’ll do a more detailed scientific review on how mTOR works within the body so as always I appreciate you being here don’t forget to check out Yugi doe Mancha down below and please don’t forget to like this video hit that red subscribe button and turn on that little Bell icon so you can always see whenever we are posting new content okay we’ve got new kinds of things coming out all the time and also hitting that little Bell icon to make it so you don’t miss the live broadcasts that I do these are really fun and interactive for the community allow me to sit down and actually answer questions one on one as much as I possibly can so you can actually join the party and be here live whenever we’re doing these videos so again appreciate you being here and as always make sure you’re keeping it locked in on your health and on this channel see you soon 

This Post Was All About Don’t Hate mTOR! (Even though it’s the opposite of Autophagy).
Don’t Hate mTOR! (Even though it’s the opposite of Autophagy)

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Mammalian target of rapamycin (mTOR) was named because a drug called rapamycin inhibited a protein that was then named, target of rapamycin (TOR). The “m” is because it’s in mammals (zebra fish TOR is, similarly, zTOR).

mTOR is central to the opposing biological processes of growth and longevity. mTOR is thought to promote growth and decrease longevity.

Basically, any process you can think of relating to muscular growth and longevity probably has some relationship to mTOR. Here are some examples:

Exercise activates mTOR signaling in skeletal muscles (growth)
mTOR inhibits autophagy (longevity)
Insulin activates mTOR (growth)
Sirtuin proteins inhibit mTOR (longevity)
BCAAs activate mTOR (growth)
Fasting inhibits mTOR (anti-growth and longevity)
And, as precited by its pathetic name, rapamycin increases (longevity), at least in mice

How exactly does mTOR impact all these processes? Well, it’s kind complicated [show image below] and there are actually two different mTOR complexes (mTOR1 and mTOR2) that have slightly different functions. So, for the sake of simplicity let’s just say this: mTOR is a kinase. This means that mTOR acts to regulate the activities of other proteins by adding a phosphate group from ATP to them. Depending on what protein it adds the phosphate to, and where on that protein it does so, is can either activate of inhibit its target and pathways downstream.

The message, in its simplest form, is that mTOR activity makes you live hot (and strong) but die young. But since when is science ever simple? What annoys me is that people tend to be scared of anything that activates mTOR because they are afraid it’s going to kill them. This is problematic thinking for two reasons:

(1) Biology is all about balanced cycles. You need periods of growth (anabolism) and breakdown (catabolism). If you’re all anabolism (like a body builder) you will die young. However, if you’re all catabolism, you’ll die even younger. In fact, one of the leading risk factors for death in the elderly is low muscle mass. You need a functional level of muscular power to live and thrive. No mTOR and you’d wither away. In short, you do want to activate mTOR on occasion. Just don’t overdo it. “Extremes are easy, the challenge is balance.” “

(2) The inside of your body is NOT a homogenous blob! Why do people always forget that fact? Just because you activate mTOR in once place doesn’t mean you activate it everywhere. For example, when you work out you activate mTOR in your skeletal muscle but might actually decrease mTOR activity in your brain. Thus, it’s possible, and I would argue probable (such studies can’t be done in humans without cutting into their brains), that exercise activates muscular mTOR but inhibits brain mTOR, giving you the exact organ-specific balance of activity that you want!

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Does Exercise STOP the Effect of Fasting

Does Exercise STOP the Effect of Fasting

Does Exercise STOP the Effect of Fasting

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there is a really cool balance between fasting and working out and I’m not talking about just like for cosmetic reasons like sure working out is gonna get you in shape fasting is gonna get you in shape now I’m talking about the cellular level like a really cool balance see it all comes down to two very specific things that i’m gonna talk about in this video mTOR and autophagy and right now that sounds complex but I promise it’s gonna make perfect sense in this video and you’re gonna have a clearer understanding of why balancing your workouts with fasting is the ultimate way to combine not only amazing metabolic and cosmetic benefits but also longevity and just long lasting health hey you are tuned into the Internet’s and leading performance fat loss keto and fasting channel new videos coming out every single Tuesday Friday and Sunday at 7 a.m. Pacific time but not just then we have videos coming out throughout the rest of the week as well I also want to make sure you head on over to highly calm so you can check out the premium performance apparel and I’m always wearing in my videos alright so what we want to look at today is we want to look at the balance between working out and fasting at the cellular level now to make some sense of this I have to give you a quick rundown of what mTOR is and what autophagy is okay some of you have heard about this stuff before so just bear with me if you have because I promise I’ll get to the good stuff mTOR stands for mammalian target of rapamycin an mTOR for all intents and purposes is just a very anabolic thing what mTOR is is something that is turned on when we are in an anabolic state meaning we have excess calories coming in and our body recognizes that as a time of excess or basically just being plentiful so it says great we have excess calories we can cell divide we can put up new cells we can have all this growth muscles can grow growth hormone can occur we’ve got i GF insulin-like growth factor all these things right it’s a time of excess okay then we have Auto Fuji which is the opposite Thapa g is a process where our cells are sort of condensing and recycling and trimming out the excess so we only have what’s truly needed okay but let’s focus on mTOR for just a second and then we’ll get into the autopsy side and how this all relates with working out and fasting so like I said mTOR occurs when your body is a rich ok I want you to think of it like that like times are good ok the stock market’s high the Dow is at 30,000 points everything’s good we’re spending money right ok this the same thing happened in your body your body’s like great I can create more energy I can create more adenosine triphosphate okay which is ATP which is energy it can grow new muscle grown ooh tissue all great okay but times of stress trigger low levels of emptor so basically when you’re stressed out when you’re literally under stress or when you’re not eating because you’re fasting your import levels go down but the opposite of mTOR is on top of G so when mTOR is down autofit G is high and when on top of G is low mTOR is high okay now again pay attention to that because it’s gonna make some sense as I get further into this video so at the end of the day we want everything cycled okay we want a cycle of high levels of mTOR and then low levels of mTOR okay high levels of em tour great because again we’re growing new cells it allows us to build more muscle unfortunately it also allows us to build more fat too but again gives us that time of excess for cells to grow Altaf G trims it down so think of it like this it’s a party M tours hi everything’s good top of G is the cleanup okay now on top of G cannot come in and clean up until the party’s done okay so I’ll top it you can’t come in and clean up all the cellular waste and everything like that until mTOR is gone until the party’s over so M tour is a party atop of G’s the cleanup crew now the cleanup crew can’t come in when the party’s still going on because nothing’s gonna happen so that’s what we have to remember is whenever we’re building muscle whenever we have an excess of calories or we’re working out we have mTOR activation we also have a higher level of waste and that’s just part of life okay so it’s like if you’re spending a lot of money or if you’re living rich you have a lot of waste – okay more money more problems right same kind of thing happening inside your body so let’s take a look really quick at the good and the bad of mTOR okay the good is increases in muscle increases in IGF where you can build more muscle increases in growth hormone okay increases in overall abundance inside your body an increase in mitochondrial metabolism the ability to actually create energy all good the bad potential for more disease extra waste downregulated immune function okay so when we have more improv and definitely can lead to increases in cancer and things like that because we’re increasing that cell growth but this is exactly where the balance comes in okay because levels that are too low with mTOR are actually bad as well so there’s a study that’s published in the journal Cell Metabolism it took a look at liver cells so hepatocytes okay and it found that when they were in a state of low mTOR for a long period of time they had sort of a chronic level of just low inflammation it was just constantly occurring now the best way to sort of give an analogy of this is it’s like they didn’t have any stress they never had a chance to actually grow and proliferate they were sheltered all the time you see em tor allows the growth so in hepatocyte your liver cells weren’t able to actually experience growth they remained these small sheltered cells that actually ended up having more stress in life because they weren’t able to handle things now the analogy that one of my team members actually gave me was like it sounded like someone that was possibly home schooled but never got the chance to ever have any social activity like okay so they were sheltered and they were never able to socialize like they’re too sheltered and then they grew up and their life was stressful because they never had any stress or experience or learned how to socialize right so that’s a perfect example of what happens if your employ levels are too low all the time so it’s exactly why we want to have them high and then low from time to time now let’s dive into the opposite of mTOR okay which is auto Fidji now auto Fidji is the cellular recycling now I’ve kind of explained it in videos before but sometimes I’m not really clear it’s not like cells literally eating each other it’s cells sort of recycling the components to become stronger so basically you have these cells and on top adji occurs when you’re in a time of stress like when you’re fasting and your cells say uh-oh we better start eating ourselves and recycling our own components so that we don’t have to start eating muscle tissue basically rather than a cell going out and eating muscle tissue and making you lose muscle first it’s first line of defense is to eat its own body parts that aren’t really being utilized so it recycles components eats them digests them recycles them you end up with a stronger more efficient cell so again to put this into context with mTOR when mTOR goes down autopsy goes up and vice versa now here’s what’s interesting is when you’re fasting amino acids trigger in tor so i’m digressing a little bit but i’ve talked about in videos how amino acids during a fast are dangerous and people always kind of give me crap about it right they always talk to me and say oh it’s like that’s such nonsense you’re getting way too way too granular here well amino acids trigger mTOR that’s defeating the purpose of the auto feed you don’t normally get one too fast so case in point here don’t have amino acids when you fast but again topic for a different day so one of the cool ways that I want you to look at this is like a bulk and a cut for yourselves now for those of you that are kind of familiar with the whole Fitness thought process of bulking and then cutting it’s like that for yourself so when you have mTOR activation with an excess of calories and working out the triggers mTOR you have your cells sort of bulking I mean they’re dividing they’re growing your time of excess so think of it like a bulk and think of autophagy like a cut it’s like you repeat that cycle in balance and you end up with a much stronger body it’s like you’re bulking you’re growing more muscle cells and then you have the action while toppity process that’s trimming them down and making them stronger you repeat rinse repeat rinse repeat and next thing you know you’ve got a bigger stronger leaner yet more efficient and longevity driven healthy cell it’s exactly what we want we want to be bigger stronger faster but also live for a long time so getting down to the nitty-gritty of it fasting increases auto Fujii tremendously but working out triggers mTOR tremendously so it actually works out if you work out in a fasted state you have a big spike of mTOR that is quickly recovered by a big spike in on top of you that occurs after the workout so although during your fasting period your workout will technically down regulate autophagy you’re doing yourself a huge service because you’re triggering mTOR without excess calories working out literally triggers imp tor okay so you’re doing that without excess calories you’re triggering this anabolic switch without having to have a bunch of food so it’s like right after that you start burning fat because on top edge is occurring and because you’re actually going into that fasted State so you’re literally getting the best of both worlds you’re triggering anabolism but then you’re triggering cell cleanup all while being in a calorie deficit that is pretty cool now the other thing is when you break your fast you’re going back into mTOR abundance you’re allowing your body to grow again and because insulin sensitivity is high import activation is going to be even higher so you have an extreme effect of streamium for activation followed by extreme town regulation and up regulation of auto fuji so that’s exactly what we want at the end of the day we’re getting balanced but we’re getting big spikes that trigger muscle growth and then trigger clean up muscle fat loss and longevity the trifecta everything we could possibly want okay so if it comes down to getting more information on fasting you know where to put your questions I want you to put your questions and any comments concerns down in the comment section below and I’ll try to answer those questions in my weekly round-up videos as always keep it locked in here in my channel and I’ll see you in the next video

This Post Was All About Does Exercise STOP the Effect of Fasting.
Does Exercise STOP the Effect of Fasting

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Does Exercise STOP the Effect of Fasting – Thomas DeLauer


mTOR responds to signals from nutrients, growth factors, and cellular energy status and controls cell growth and proliferation based on this (by regulating protein synthesis)

In other words, whenever we have an increase in nutrition (mainly protein) and calories we essentially tell the body that plentiful times are here – our cells increase their working capacity and ATP production is increased

Cells increase division and we are then primed for growth and repair – mTOR is the protein that senses this

It’s important to realize that mTOR is neither good nor bad, but too much or too little can have negative consequences

You see, mTOR increases energy production, but also creates more junk products

Autophagy is the process that degrades these junk products, but it is only usually active when mTOR is decreased

The Good & Bad of mTOR Activation

The Good

mTOR activation allows us to put on more muscle (and fat) and we
increase various hormones such as IGF-1

mTOR increases ATP production and creates new mitochondria – it also increases mitochondrial metabolism (by activating PGC1a)

The Bad

Too much mTOR activation, however, contributes to a large number of human diseases, including cancer, obesity, type 2 diabetes, depression and neurodegeneration


A study published in the journal Cell Metabolism found that too little mTOR activation can be equally as bad as too much

The study found (in rats) that too little mTOR activity actually harms the liver – mice were fed an excess calorie diet, but given rapamycin to induce autophagy

Researchers found that persistent suppression of mTORC1 activity in the liver leads to low-level inflammation that is enhanced by feeding a HFD

Hepatocytes bearing deficient mTORC1 activity are less competent to cope with oxidative stress and other inflammation-related insults

Note: HCC is the fifth most common cancer subtype worldwide, with a median survival of 6–16 months after diagnosis

Persistent elevation of hepatic mTORC1 activity in the setting of overnutrition and obesity, or conversely, protracted suppression of mTORC1 activity induced by rapamycin and related drugs, sets in motion a spiraling sequence of pathologic events that promotes HCC.


The opposite side of the mTOR coin is the repair and recycling system – it’s activated with the mTOR switch is turned off

And, as we know, the main process that carries out repair and recycling in our cells is called autophagy

Autophagy is the mechanism our cells use to recycle damaged proteins and cell machinery (including mitochondria) and use their parts to make new machinery and new sources of energy – recycling old cellular machinery helps protect a cell from premature aging

Autophagy allows your cells to recycle used material for use as energy during stresses such as fasting, instead of breaking down valuable things such as muscle – preventing catabolism (breaking down) of muscle is always a good thing

Autophagy occurs at a low basal level in virtually all cells, being important in protein and organelle turnover – however, it may be up-regulated in times of need

When mTOR goes up, it shuts down autophagy – mTOR is sensitive to dietary amino acids (protein)

Fasting & Working Out

Journal – Autophagy

Fasting increase autophagy (as does caloric restriction and certain foods; EGCG, ginger, curcumin, etc.)

Explains that resistance training activates mTOR (as does protein, excess calories, IL-6, testosterone, etc.)


1) Jung CH , et al. (n.d.). mTOR regulation of autophagy. – PubMed – NCBI. Retrieved from
2) mTOR Pathways in Cancer and Autophagy. (n.d.). Retrieved from
3) Glick D , et al. (n.d.). Autophagy: cellular and molecular mechanisms. – PubMed – NCBI. Retrieved from
4) Autophagy fights disease through cellular self-digestion. (28, February). Retrieved from
5) Autophagy fights disease through cellular self-digestion. (28, February). Retrieved from
6) Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle. (n.d.). Retrieved from
7) Short-term fasting induces profound neuronal autophagy. (16, August). Retrieved from /

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