Don’t Hate mTOR! (Even though it’s the opposite of Autophagy)
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mTOR is what grows your muscles but mTOR is also what is decreasing your longevity you see we always talk about otology and if you do watch my videos frequently then you know what auto fit is auto AG is where your cells are recycling just weaker components of themselves and organelles so basically they just kind of recycle a portion of a cell when you’re in starvation mode or anything like that well to give you a simple example mTOR is the opposite so in today’s video I want to just give you a lay of the land of what import is and how it’s working inside your body and when you want surges of mTOR versus circuits of auto fuji you see within our bodies we have opposing biological processes and what I mean by that is we always have a balance of growth and we always have a balance of longevity so growth and longevity compete with each other and eventually one wins right okay so we obviously want longevity now mTOR is related with growth the whole purpose of mTOR is to activate growth which is in essence the opposite of longevity so you would think in theory that mTOR is really really bad we don’t want em tor because it decreases longevity but again we all come back to when we want it when we want growth so I want to break this down in some simple examples that you have an understanding exercise okay that triggers mTOR it triggers growth in the skeletal muscle growth okay fasting that inhibits mTOR triggers Auto Fujii that is longevity then insulin activates mTOR insulin is growth mTOR is growth so whenever we eat we activate mTOR growth versus longevity same with branch chain amino acids okay you take a branched chain amino acid supplement because you’re trying to build muscle you’re also activating M torque which means you’re activating growth then we have another thing called sirtuins now if you’re a science nerd you notice or – it is but a sirtuin is sort of an anti-aging compound in the body okay sirtuins are sort of the opposite of mTOR as well so fortuyn’s being longevity the opposite of mTOR which is growth the point is we have these things okay em tours all about growth and on top of G is all about longevity but how is this process working within your body and what do you need to know as a lay person that’s just trying to get through life and live for the longest amount of time possible well mTOR is complicated okay we have mTOR one we have mTOR two and they do different things in fact if you look at the image that’s up on the screen right now you’ll see that mTOR is pretty complicated what this image is depicting is it’s showing how imp tor stands in the way or impedes or allows certain processes to happen within the body you see here’s how it works mTOR is what is called a kinase okay and a kinase is something interesting and that it takes a phosphate group it takes a phosphate molecule rather from ATP what this means is it basically takes a phosphate molecule from energy creation and it randomly throws it along with other proteins so basically a kinase like mTOR regulates other proteins and therefore determines what the downstream paths are downstream result is to make this very very simple basically mTOR is something that dictates what direction the body goes and where let me give you a very clear analogy let’s say for example you have a river and a river that is flowing super smoothly with no impedance whatsoever right it’s just flowing along okay then all of a sudden you take a big giant pillar or a big rock and you plop it smack right in the middle of the river so the rivers gone from having this clean flowing just life – all of a sudden having a disturbance and disruption where it has to divert water around the rock to the right and around the rock to the left well suddenly you’ve taken the energy in the force of that River and you’ve concentrated it in one direction and in another direction that rock or that pillar is mTOR okay it came in it disrupted a protein and it all depends on where it hits in terms of that protein and it changed the direction of the downstream path so it diverted water off to the right and left which in this case is growth off to the right and left so for instance when you work out you trigger mTOR in the skeletal muscle tissue that’s like putting a rock you know a specific area of the river that’s gonna allow it to grow muscle okay it’s hypothetical obviously so you can see how mTOR is not necessarily as activated in your entire body it’s activated in specific spots and it all depends on where it puts that phosphate group or phosphate molecule within a given protein so depending on where it adds it it can either activate different processes or inhibit different processes you see put the rock in the middle of the river and it’s going to inhibit otology but it’s going to activate growth so I know that’s a little bit complicated but I hope it all makes sense hey I do want to stop for one second if you haven’t already hit that red subscribe button please do it if you haven’t hit that Bell icon I encourage you to do so as well so you never ever ever miss a beat and also all the things that we’re talking about it’s all about keeping in balance okay so if we have mTOR activation that’s really high obviously that’s pro-growth and anti longevity I just want to make a note that there’s things that you can implement into your life to increase autopsy to balance the mTOR okay we’ll talk about that a little bit more but like green tea matcha green tea is probably one of the best ways throughout the course of the day that you can at least encourage otology to occur and if you got em tour and etapa g always in a constant balance so if you’re doing things like lifting weights and working out you want to be sipping on green tea so that you can at least crush some of the mTOR levels that might go on long term okay now I’ll talk a little bit more about that later if you guys do want to check out some of the matcha that I recommend there’s a special link for yugioh matcha down below a 100 80 year-old matcha company they sponsor a lot of videos on my channel and they’re super super awesome super clean and they have these little to go packets that you can just like literally put it in some water put it in some almond milk whatever you want to do and just be on the go and have your matcha packet so special link down below in the description so when we look at mTOR as sort of this live hot die young sort of thing it gives us a little bit of an understanding okay a very extreme hypothetical example would be let’s take some of that’s only focused on muscle growth right only focus on anabolism they focus on how big can I get my muscles well obviously they’re going to focus only on that and eventually there’s no focus on longevity they’re probably going to I younger right okay it’s just like we have to look at that so the live hot die fast die young kind of thing truly is there we want mTOR we just want it at specific points in time we want import after workout we want mTOR when we’re trying to build muscle but we want to balance it with otology employ is not bad we need to have these balanced cycles for every little bit of emptor activation that we have we have growth which means we have waste which means that we need to have proper breakdown – okay additionally looks like said we want to have these surges all the time it’s also funny to think that too much auto Fuji is bad too in fact catabolism in elderly patients is one of the biggest risk factors for death so what that means is that if you have too much of the opposite of mTOR it’s a big risk factor for death just as much as mTOR is a big risk factor for death if you have too much like it’s never really been proven that mTOR is a risk factor for death it’s all just a balance once again if you focus only on growing new tissues ie cancer things like that obviously you’re gonna have a problem okay so it’s all about the balance so how you do that is up to you meditation fasting in conjunction with periods of mTOR sipping on green tea to induce autophagy while also having meals at certain times to induce mTOR and one last very important thing that we need to realize is that we are not just some homogenous blob that has an on or off switch and what I mean by that is we don’t just activate mTOR in our entire body it’s not how it works just like we don’t activate auto Fiji in our entire body all at once okay when we’re fasting for instance we trigger hepatic auto Fiji first that means auto Fiji within the liver the liver cells start to regenerate first because they’re the most active in metabolism so the second that they get a break they start to recycle well believe it or not you could have mTOR being activated in your brain at that very point in time that your liver is going through Auto eg and also when you’re working out and you’re inducing skeletal muscle mammalian target of rapamycin there’s a very good chance because blood flow and nutrients are going through the muscles that your brain is in a state of auto fiji or not having mTOR activated so it’s not like you have mTOR just on and like so the point saying this is eating isn’t bad working out isn’t bad activating mTOR isn’t bad I’ve talked to people that simply think that if they have mTOR being activated that they’re building cancer cells it doesn’t quite work like that however if you live your life in a constant mTOR state because you’re constantly eating and you’re constantly doing things like that then yes there probably is some indicator I’m not a doctor that out there it’s showing that yes you were probably building cancer cells and you’re probably promoting the growth of things that shouldn’t be there the point is keep it balanced sipping green tea fast regularly but don’t be afraid have a big surge of food don’t be afraid to have a big bolus of protein to trigger mTOR so you can actually recover so the goal of this video was to help people not be afraid of mTOR if you want a more in-depth breakdown of mTOR I’m happy to do one just let me know down in the comment section below and I’ll do a more detailed scientific review on how mTOR works within the body so as always I appreciate you being here don’t forget to check out Yugi doe Mancha down below and please don’t forget to like this video hit that red subscribe button and turn on that little Bell icon so you can always see whenever we are posting new content okay we’ve got new kinds of things coming out all the time and also hitting that little Bell icon to make it so you don’t miss the live broadcasts that I do these are really fun and interactive for the community allow me to sit down and actually answer questions one on one as much as I possibly can so you can actually join the party and be here live whenever we’re doing these videos so again appreciate you being here and as always make sure you’re keeping it locked in on your health and on this channel see you soon
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Mammalian target of rapamycin (mTOR) was named because a drug called rapamycin inhibited a protein that was then named, target of rapamycin (TOR). The “m” is because it’s in mammals (zebra fish TOR is, similarly, zTOR).
mTOR is central to the opposing biological processes of growth and longevity. mTOR is thought to promote growth and decrease longevity.
Basically, any process you can think of relating to muscular growth and longevity probably has some relationship to mTOR. Here are some examples:
Exercise activates mTOR signaling in skeletal muscles (growth)
mTOR inhibits autophagy (longevity)
Insulin activates mTOR (growth)
Sirtuin proteins inhibit mTOR (longevity)
BCAAs activate mTOR (growth)
Fasting inhibits mTOR (anti-growth and longevity)
And, as precited by its pathetic name, rapamycin increases (longevity), at least in mice
How exactly does mTOR impact all these processes? Well, it’s kind complicated [show image below] and there are actually two different mTOR complexes (mTOR1 and mTOR2) that have slightly different functions. So, for the sake of simplicity let’s just say this: mTOR is a kinase. This means that mTOR acts to regulate the activities of other proteins by adding a phosphate group from ATP to them. Depending on what protein it adds the phosphate to, and where on that protein it does so, is can either activate of inhibit its target and pathways downstream.
The message, in its simplest form, is that mTOR activity makes you live hot (and strong) but die young. But since when is science ever simple? What annoys me is that people tend to be scared of anything that activates mTOR because they are afraid it’s going to kill them. This is problematic thinking for two reasons:
(1) Biology is all about balanced cycles. You need periods of growth (anabolism) and breakdown (catabolism). If you’re all anabolism (like a body builder) you will die young. However, if you’re all catabolism, you’ll die even younger. In fact, one of the leading risk factors for death in the elderly is low muscle mass. You need a functional level of muscular power to live and thrive. No mTOR and you’d wither away. In short, you do want to activate mTOR on occasion. Just don’t overdo it. “Extremes are easy, the challenge is balance.” “
(2) The inside of your body is NOT a homogenous blob! Why do people always forget that fact? Just because you activate mTOR in once place doesn’t mean you activate it everywhere. For example, when you work out you activate mTOR in your skeletal muscle but might actually decrease mTOR activity in your brain. Thus, it’s possible, and I would argue probable (such studies can’t be done in humans without cutting into their brains), that exercise activates muscular mTOR but inhibits brain mTOR, giving you the exact organ-specific balance of activity that you want!
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