2 Types of Inflammation You NEED to Know About (and How FASTING Helps)
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I’m damp and I’m pimp and weren’t dampen and pampered alright what I’m talking what I’m talking about here is a really interesting thing within the body damp and Pam it kind of sounds like a dr. Seuss thing but it’s actually a really very sophisticated process in the body damp stands for damage associated molecular pattern PAMP stands for pathogen associated molecular pattern let me paint a clear picture for you in relationship to intermittent fasting damp is all about your body recognizing that there is internal damage somewhere okay if you have damage to tissue it’s going to cause a leakage of DNA or a leakage of particles into the bloodstream where your body is going to recognize that something’s wrong so it’s gonna trigger inflammation let me give you just a simple example you have mitochondria where your body produces energy okay where you’re just it’s the energy powerhouse within the cell okay well if you are under stress or if you are eating the wrong kinds of foods or you’re not practicing intermittent fasting enough and things like that well what can happen is this mitochondria gets damaged now that comes to know a whole world of problems in and of itself right damaged mitochondria is a damaged factory you don’t want damaged energy factories but in addition to that it has holes in it and it leaks its own DNA because yes our mitochondria has its own DNA and what that means is when you’re not fasting and things like that you’re gonna have this leakage of DNA and that triggers damp because it’s the job of damp to be damage associated molecular patterns it notices damage to the tissue so it signals the immune system that DNA is not supposed to be here we must have a problem and why does this happen well think about it if you were to have a wound if you were to slice your hand open or something like that well you would have just your own tissue your own particles that would signal damp and it would trigger your immune system to fix that well it’s happening inside our bodies too and this is one of the reasons we feel chronic inflammation okay chronic inflammation is not something we like it feels like we’re running uphill all the time it’s not fun stuff now if we have metabolic damage going on we have a high degree of dam and we our immune system is activated consequently we have inflammation but we’re going to talk about PAMP – because damp and PAMP work together hey I almost forgot please do hit that red subscribe button and then please hit the bell icon so you never ever miss our daily videos okay now I’m going to talk about ways that you can kind of mitigate this okay the best way that you can mitigate damp is to do some intermittent fasting now I shouldn’t say the best way okay because I have to be realistic there’s probably other ways too but my opinion in the best way is going to be to practise intermittent fasting why because you improve what’s called mitochondrial density you make the mitochondria stronger so your body can produce energy more and thusly one could argue that that’s going to create less damp less overall chronic inflammation now when you look at other studies you can see the inflammation gets modulated across different molecular pathways and different protein systems in the body you need a via fasting but I really wanted to just focus on damp and Pam now let’s jump over to pimp for just a second okay tamp is pathogen associated molecular pattern this is just like damp except instead of your body responding to its own tissue its own DNA and noticing an internal problem it’s responding to an external problem okay like a bacteria coming in or something like that right now one of the biggest potential causes of PAMP within the body is going to be basically a breakdown of the barrier that protects our body from what’s in our gut okay now I’ve talked about this stuff before and it may seem like kind of just weird science and might be kind of boring but let me make it a little bit cooler okay our gut is supposed to be sealed up with a mucosal layer okay and when that mucosal layer is weakened because of chronic inflammation what happens is lipopolysaccharides which are little guys that live inside of our gut and they live on the bacteria within our gut they get a chance to leak into the body when they leak into the bloodstream it triggers Pam because as far as the body is concerned it is a pathogen it is a pathogen because it’s bacteria that’s supposed to be in our gut not in our bloodstream so PAMP gets elevated well your we starting to do the math here damp because that’s you know damage associated molecular pattern that gets elevated with just inflammation from stress and poor diet now then that inflammation affects our gut and it’s our gut lining well what happens then is then PAMP gets elevated so we have damp and PAMP working together causing this dampened Pam pin problem right okay so what else can we do like how does this process work well the best thing that we can really support the inflammatory process and make sure that we don’t have too much stuff leaking from the gut barrier is going to be by supporting our gut mucosal layer okay intermittent fasting has been shown to support that gut mucosal layer now there’s other ways to in like collagen and stuff like that by the way people do ask me like things that they can consume that are going to be really good for the gut mucosal layer I would highly recommend using bone broth I put a link down below for kettle and fire so if you want to get some bone broth there’s gelatin and there’s collagen and bone broth which has been shown in other studies to help contribute to a healthy gut lining and help support the gut so I really do I mean as far as flavor goes and everything like that they’re my personal favorite but I also put a link down below so you can get a special pricing on them fYI they are a huge supporter and sponsor of this channel so I appreciate them dearly because they make all this content possible so if you want to support this channel best way to support this channel is to support my sponsors so please do check them out down below in the description I don’t think you’ll be disappointed anyhow let’s watch the rest of the video first so when we give ourselves more of that gut mucosal layer then we’re preventing those lipopolysaccharides and getting in the bloodstream and they remain contained where they should now there is something that was published in scientific reports that found that women that fasted or women that just went through typical caloric restriction they had a massive improvement in their gut mucosal layer but as a direct result of that they had a big decrease in lipopolysaccharide content within their bloodstream meaning their immune system wasn’t having to work on fighting these lipopolysaccharides so that’s just one scientific report okay there’s a lot of different things that show that intermittent fasting can play a big role there we also have to look at inflammation as a whole and what’s kind of happening okay our immune system is a little bit under active when we’re fasting to begin with so not only do we potentially lessen the signaling system the damp and pay up we’re also lessening their effective and I’ve talked about this in multiple videos but we do want to reduce the immune systems effectiveness when we’re talking about chronic inflammation but we don’t necessarily want to reduce the effectiveness when we are talking about acute immune response and we want to actually be able to protect ourselves from any kind of pathogen or virus or whatever right you just want to make sure that you’re careful they’re too much fasting can actually compromise the immune system by crushing it too much there’s a delicate balance we want to bring inflammation down just enough so that we don’t have chronic inflammation but we don’t want to bring it down so much that we’re basically affecting our immune system negatively so what I would usually recommend is doing things like shorter term fasts maybe slightly more frequently or doing things like I’ve even talked about before bone drops fasts where you’re still having calories coming in but you’re getting that gut mucosal support and you’re being able to provide your gut the restorative effect that it needs but also just being able to keep the calories in so you’re not going on super long extended fasts you know when you do break your fast some of the things you’re gonna really want to be paying attention to definitely don’t be having sugar coming in okay sugar has been demonstrated to cause some issues with the again mucosal layer but also triggering that leaky gut issue where the life of polysaccharides weaken we always think that leaky gut is just an over marketed term and it is quite frankly it’s over marketed and it’s abused but it’s a real thing and it’s in the scientific community those lipopolysaccharides are a real thing so when you do break your fast and my recommendation would be to break your fast it’s like lean protein break your fast and then later on have some good healthy fats don’t just introduce a ton of carbs into the mix right out the gate especially sugar because that could end up negating the entire effect of your fast as far as the gut goes as far as that gut barrier goes remember damp and PAMP are good to some degree but we don’t want them constantly elevated and if you end up going backwards because you increase your damp and you increase your PAMP because you break your fast wrong then that could cause a myriad of other problems I do have other videos on how to break a fast down below in the description as well as always do you keep it locked in here in my channel I’ll see you tomorrow
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Just DAMPing and PAMPing!! Ok, you are probably wondering, “what is DAMP & PAMP?!” In regards to IF, understanding these two can help out you get more out of your fast AND address GUT INFLAMMATION! Let’s dive in and I’ll see you in the COMMENTS!!
Low-grade chronic inflammation might be induced by two distinct mechanisms. DAMP stands for the damage-associated molecular pattern – patterns signalling internal damage. We already mentioned one type of cellular damage –the ruptured mitochondrial membranes. Such damage allows for the release of mitochondrial DNA and this DNA acts as DAMP. The mitochondrial DNA signals damage because in the normal state it is not present outside the mitochondria.
PAMP stands for pathogen-associated molecular pattern, the foreign particles signalling that there is a pathogen present. The ability to sense PAMP is integral for the immune system as the binding of the PAMP to immune receptors triggers the immune response. One such PAMP can be lipopolysaccharide (LPS), a molecule present on bacterial membranes. Our gut is full of bacteria with LPS but the mucous is preventing their contact with the gut lining. However, the western diet is associated with higher gut permeability, decreased mucous production and therefore LPS can get into the bloodstream where it triggers a response. If the gut barrier integrity is compromised continuously, LPSs are constantly leaking to the bloodstream and cause the low-grade inflammation.
Intermittent fasting can help in multiple ways against the damage caused by LPS. First of all, it can stop the problem at the very beginning by improving the integrity of the gut. This mechanism was reported in a study published in Scientific Reports. In a group of 20 women, very low-calorie diet for four weeks significantly improved the gut barrier function and levels of circulating LPS were much lower after the 4-week diet.
LPS can have a negative effect on our cognition. Chronic neuroinflammation significantly increases the risk of neurodegenerative diseases. Promisingly, in a study published in the Journal of Neuroinflammation, intermittent fasting (IF) was found to attenuate the LPS induced neuroinflammation. The beneficial effect is achieved by the activation of NF-kappaB. This transcription factor has a somewhat conflicting function in the brains. It can be activated by LPS and then it rapidly increases the expression of several pro-inflammatory genes. On the contrary, it can also stimulate genes involved in synaptic plasticity and cell survival. In here they reported that IF makes the NF-kB go the neuroprotective way. Further, LPS usually reduces levels of BDNF, a protein crucial for brain health. IF managed to prevent the LPS induces a decrease in BDNF. IF also prevented elevation of pro-inflammatory cytokines IL-1α, IL-1β and TNF-α levels.
However, outside of the brain, the NF-kB pathway might have more detrimental effects as suggested by the study published in Free Radical Biology and Medicine. As it was discussed previously, chronic inflammation can induce fibrosis in tissues where we don’t want it. In this study, alternate day fasting was able to inhibit the inflammation and fibrosis by suppressing NF-kB pathway.
The detrimental effect of NF-kB is further supported by a study published in Experimental Neurology. In ischemic stroke, inflammasomes NLRP1 and NLRP3 play a major role in motor impairment and neural cell death. In here we can describe the concept of DAMPs. After a stroke, the necrotic tissue without oxygen releases DAMPs (little pieces of the membrane) and these trigger inflammation through activation of NF-kB. In turn, NF-kB activates the NLRP1 and NLRP3 inflammasome. However, IF suppressed the activation of NF-kB and subsequently levels of expressed inflammasomes NLRP 1 and 3 were reduced as well.