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I’m pulling out all my stops right now seriously I’m gonna go out on the limb I’m gonna say that this is the one trick one thing that you should know about your diet that is the cardinal rule okay I’m pulling out all the stops for me to say that that means I can never say that again right so literally this is the most important thing and that is to never combine your fats with your carbs and I’m gonna explain exactly why and you’re gonna have a very concrete understanding and it’s all gonna make sense so please stick with me to the end of this video so you have a full comprehension of this and you’re not just getting little bits and pieces you’re tuned into the Internet’s leading performance nutrition and fat loss channel with new videos on Tuesday Friday and Sunday at 7 a.m. Pacific time they also wanna make sure you hit that subscribe button and then hit that Bell icon so you can turn on notifications know whenever I feel alive also want to make sure that you check out butcher box 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we have this huge double whammy effect okay now I’m gonna give you a very broad oversimplification of this whole video first and then I’ll break it down more insulin when we eat carbs opens up the cell okay it allows the cell to receive glucose the whole function of insulin is to allow the cell to open up to receive glucose we eat carbs insulin spikes so the carbs come into the cell because insulin opened the door well the door is open so if we ate fat with those carbs any burglar or any bad guy can come in the cell because insulin open to the door so if carbs open the door then fats gonna come along in for the ride okay now that is not biologically correct but that’s an oversimplification to at least get the point across now let’s break down the other hormones that are at play and why this whole process is so very important insulin ultimately stores fat because it activates lipoprotein lipase okay insulin stores fat because it turns on a fat storing enzyme but it also slows down fat burning because it turns off hormone sensitive lipase so in simple terms it turns on fat storage and turns off fat burning but there’s two other hormones that work synergistically with insulin okay and they also complement each other in negative ways I guess so let’s talk about those the first one is oscillation stimulating protein or ASP okay so in this video I’m gonna call it a SP a ASP is actually triggered by fat okay so when we consume fat a SP is elevated and a SP triggers insulin so yes even if you consume pure oil pure fat you will still spike your insulin who would have fun okay so you eat fat hey SP spikes which causes insulin to spike but here’s where it gets really crazy that insulin has a negative feedback loop so what that means is the insulin that you’ve already spiked causes more a SP so fat causes a SP causes insulin which causes more a SP which causes more insulin which causes more a SP where does it end it’s a negative feedback loop that can get bigger and bigger and bigger so fat can indeed spike your insulin and store more fat we’ll talk about how this gets exponentially dangerous when you mix it with carbs in just a moment but I want to talk about the next hormone which is glucose dependent insulin atrophic protein okay this one is more so in the gut okay and this one is really interesting so here’s an analogy or not even analogy example if we consume glucose our insulin levels going to spike pretty high if we consume carbs our insulin levels going to go up pretty high but if we were to inject glucose or carbohydrates right into our bloodstream or our insulin wouldn’t spike as high as if we ate it okay that’s because again this GIP this other protein this other component that’s in our gut is sensitive just in our debt now this is where things get really interesting we look at fats and carbs again so fats trigger GIP GIP stores fat directly but insulin or carbohydrates also trigger GIP so let’s break it down like this here’s how carbs and GIP store fat carbs alone equals insulin that equals fat storage another scenario carbs alone equals GIP which equals insulin which equals fat storage so carbs trigger fat storage two ways okay fat alone triggers a little bit of GIP just a small amount okay but through a different mechanism so fats and carbs trigger a double whammy of GIP okay so then we have fats that trigger GIP carbs are also triggering GIP but then carbs are also triggering insulin so when we combine them together we have a huge spike in insulin via the GIP pathway okay so you don’t have to understand all the complex parts of this but you do have to understand that hormonal e when we combine fats and carbs we open that cell door way wide open so j-just flood in like crazy okay now let’s talk about that asp for a second okay a SP is stimulated by that remember okay SP is not stimulated by carbs but it is indirectly because of the insulin we put it like this if you consume carbs alone you have a spike in insulin okay that’s like an insulin stores fat by itself but that spike in insulin also triggers a SP which triggers more fat accumulation if we have fat alone then we spike our SP which stores fat through a different pathway if we combine fats and carbs then we’re storing fat two ways we’re storing it from the carbs spiking the insulin and we’re also storing it from the fat activating the ASP okay I know it’s super super complex the point is is that fat activates different fat storage mechanisms and carbs activate other fat storage mechanisms but carbs and fats combine compound each other so that it’s more than just one plus one it’s like one plus one equals seven the point is don’t open the cellular door unless you are very very clear with what’s going to go into the cell so you either go high fat with no carbs or super low carbs or you go high carb or moderate carb with very low fat with meals together okay you don’t want to combine the to have a high fat low carb breakfast and have a high carb low fat lunch okay just mix them up but don’t combine them together don’t have the eggs and toast if you want to do carbs and fats separate your meals high fat meal high carb meal create a line a clear line between them and I promise you this is going to help you stay healthy and stay lean and make it so that you’re not accumulating gobs of fat simply because of this like hormonal smorgasbord that’s just a bunch of chaos in your body so I know that it’s a complex subject but the end message is simple that’s separate carbs separate if you want me to give you some more ideas on this in terms of what this actually looks like like how much should you combine of e-soo yada yada let me know but I want to make sure there’s some interest in this video first before we take it a step further as always make sure you’re keeping it locked in here on my videos and I’ll see you in the next
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#1 Thing You Should Never Do When Dieting – Thomas DeLauer
Insulin is a fat storing hormone because it increases the major fat storing enzyme in the body called lipoprotein lipase (LPL)
It also decreases hormone sensitive lipase (HSL), the major fat burning enzyme, and slows fat oxidation by suppression of CPT-1 (the rate limiting step in fat burning)
So if decrease insulin, fat storage becomes slowed while fat release and burning is sped up
Other Fat Storing Hormones
Aside from insulin, there are (at least) 2 other fat storing hormones
One of them is called acylation stimulating protein (ASP) – where insulin is induced by carbs, ASP is induced by fat and both ASP and insulin stimulate the secretion of each other
So fat does stimulate insulin & insulin stimulates a fat storing helper ASP
Another storing hormone is a gut produced signaling molecule called glucose-dependent insulinotropic peptide (GIP)
GIP is induced by both carbs & fat – GIP has its own fat storing action on LPL and causes more insulin to be released
Glucose-dependent insulinotropic peptide (GIP)
Glucose-dependent insulinotropic peptide is a hormone released from the small intestine that enhances the release of insulin following the intake of food.
Glucose-dependent insulinotropic peptide is made and secreted mainly from the upper section of the small intestine from a specific type of cell known as the K cell
Its main action occurs in the pancreas where it targets beta cells, which produce insulin. Glucose-dependent insulinotropic peptide stimulates the release of insulin from the beta cells in the pancreas in order to maintain low blood sugar levels after eating.
The main trigger for glucose-dependent insulinotropic peptide release is food, in particular fatty foods or those foods that are rich in sugar.
Once released into the bloodstream, levels of glucose-dependent insulinotropic peptide do not remain high for very long. It is broken down quite quickly (after about seven minutes) and therefore does not remain in the circulating blood for long.
Acylation Stimulating Protein (ASP)
ASP is produced through a process involving three proteins: C3, factor B and adipsin, which are secreted by adipocytes – it’s an adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes
ASP has a primary role in the regulation of lipid metabolism in adipocytes, where it stimulates glucose uptake, increases the activity of diacylglycerol acyltransferase, and inhibits hormone-sensitive lipase activity
In cellular studies, ASP increases fat storage through increased triglyceride synthesis and decreased intracellular lipolysis
Fats & Carbs
This means both carbs and fat cause fat gain, and when they are combined together they can result in even more
Eat carbs and you release insulin, and you also release GIP – GIP also causes the release of insulin itself
ASP is stimulated directly by fat and is stimulated indirectly by carbs because insulin stimulates ASP as well, and then ASP stimulates insulin
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5) McIntosh CH , et al. (n.d.). Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). – PubMed – NCBI. Retrieved from
6) Critical review of acylation-stimulating protein physiology in humans and rodents. (n.d.). Retrieved from
7) Acylation-Stimulating Protein (ASP). (n.d.). Retrieved from
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10) Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward. (n.d.). Retrieved from 5